Glutathione is an antioxidant that protects body cells from oxidative stress and damage. Tylenol is the brand name for acetaminophen, an over-the-counter fever reducer and pain reliever used by over 60 million people each week. When considering the use of Tylenol and glutathione together, it is crucial to understand how they may interact and the potential effects on the body’s health and well-being.
Acetaminophen (Tylenol), also known as paracetamol, toxicity is the number one cause of hospital admissions for liver failure in the United States, according to Dr. David D. Moore, professor of molecular and cell biology at Baylor College of Medicine. Acetaminophen is found in over 600 different over-the-counter and prescription medications. Acetaminophen overdose is the leading cause for calls to Poison Control Centers and accounts for more than 56,000 emergency room visits and 2,600 hospitalizations. According to the U.S. Centers for Disease Control and Prevention, acetaminophen poisoning is responsible for about 300 deaths annually in the United States.1 Read on to learn more about Tylenol and Glutathione.
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Do Tylenol And Ibuprofen Deplete Glutathione?
When a person takes acetaminophen, the liver produces small amounts of a potentially harmful compound called NAPQI (N-acetyl-p-benzoquinone imine). As long as you have healthy amounts of glutathione in your liver, NAPQ1 will be neutralized.
In one study, researchers found that acetaminophen decreased glutathione levels in the body.2
How Does Tylenol Cause Liver Damage?
When taken according to dosage guidelines, Tylenol is metabolized in the liver through sulfation and glucuronidation. A small percentage of your Tylenol dose is directly excreted in your urine. The cytochrome P-450 system oxidizes another small percentage into NAPQ1. NAPQ1 is detoxified by glutathione in your liver into a nontoxic acetaminophen-mercapturic compound, which is excreted in your urine.
If you take too much Tylenol or do not have enough glutathione in your liver, NAPQ1 builds up and damages liver cells, leading to liver failure.
What Are The Stages Of Tylenol Toxicity?
Tylenol toxicity has traditionally been divided into four stages.3
Stage 1
Stage one is characterized by nausea, vomiting, nonspecific right upper abdominal pain, and other nonspecific symptoms. These symptoms begin within a few minutes to hours after Tylenol consumption.
Stage 2
On days two to three, initial symptoms will begin to decrease, and liver symptoms may increase, including upper abdominal pain and increased liver enzymes, indicating liver cell damage.
Stage 3
By days three to four, peak liver injury occurs. Severe liver injury affects other body organs because toxins are not neutralized and excreted.
Symptoms include:
- Brain dysfunction (encephalopathy)
- Yellow color to eyes and skin (jaundice)
- Inability to clot blood (coagulopathy)
- Too much acid in the blood (metabolic acidosis)
- Low blood glucose (hypoglycemia)
Stage 4
People who survive stage 3 will begin to recover.
How Do You Treat Tylenol Toxicity?
Acetaminophen (toxicity) is treated with N-acetylcysteine (NAC). NAC is a glutathione precursor that augments acetaminophen sulfation in the liver and restores glutathione stores. NAC scavenges free radicals, increases oxygen delivery to the liver, and has antioxidant effects. If you are treated within 8 hours of taking an excessive amount of Tylenol, your liver will be protected from hepatotoxicity (liver poisoning), though some people will develop acute liver failure.
How Do You Replenish Glutathione?
To protect your liver, stay within the dosage recommendations for Tylenol. Studies suggest that pain relief is not increased by taking larger doses.
If you take Tylenol and are concerned about your liver’s health, talk to your doctor about supplementing with glutathione. People low in glutathione seem to be more prone to acetaminophen toxicity. Glutathione is found in fruits and vegetables, and meats. Glutathione supplements also come in multiple forms, including nasal sprays, troches, injections, and rapidly dissolving tablets.
Conclusion to Tylenol and Glutathione
Do you have questions about glutathione and how it may benefit your health and protect your liver? Contact the treatment specialists at Invigor Medical to learn more about this product and how you can buy glutathione which may improve your overall health.
