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Buy Trimix Injections


Trimix - Treatment Plan Image
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Buy Trimix Injections


Trimix (papaverine, phentolamine, and prostaglandin E1) is a highly effective (89%-95%) and quick-acting ED treatment. Trimix is a compounded drug that acts synergistically, with each component amplifying the effects of the others. Approximately 70% to 80% of men are highly satisfied with penile injections.
$249 per Vial
Benefits of Trimix
  • Improved erectile function
  • High efficacy
  • Rapid onset
  • Low risk of systemic side effects
Trimix Dosage Info
  • Dosage varies from 5 units to 50 units.
What’s Included?
  • Rx Consultation
  • Supplies
  • Support
Trimix Side Effects
  • Pain or discomfort at the injection site
  • Bruising or bleeding at the injection site
  • Swelling at the injection site
  • Erection lasting more than four hours (priapism)
  • Infection due to poor injection technique
> See all side effects


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What is Trimix?

Trimix is a compounded drug that works synergistically, with papaverine, phentolamine, and prostaglandin E1 enhancing the effects of each. Trimix relaxes smooth muscle that lines blood vessels, widening their lumens and increasing blood flow into the penis, resulting in a firm and long-lasting erection.

Benefits of Trimix

Trimix injections are an extremely effective erectile dysfunction treatment option for men of all ages, including those who have diabetes and cardiovascular disease. Bimix and QuadMix offer alternative medication combinations for men who may be sensitive to prostaglandin E1 or would benefit from adding atropine.

How Does Trimix Work?

Papaverine, phentolamine, and prostaglandin E1 increase blood flow to the penis. Phentolamine inhibits chemicals that cause blood vessels to constrict and reduce blood flow. Papaverine is a phosphodiesterase inhibitor that, like oral ED medications, increases nitric oxide, which stimulates blood flow to the penis. Prostaglandin E1 raises cGMP levels, which dilate blood vessels and relax smooth muscle in the penis.

Why might you need Trimix?

Trimix is ideal for men who have tried PDE5 inhibitors without success or who have experienced side effects while taking these medications. Men with cardiovascular risk factors or who prefer to inject Trimix as needed for improved erectile function are also excellent candidates.

Benefits of Trimix

Improves erectile function

Papaverine, phentolamine, and prostaglandin E1 increase blood flow to the penis. Men who do not have venous leak syndrome can benefit from Trimix because it relaxes smooth muscle in blood vessels and the penis, increasing blood flow into these spaces.

Highly effective ED treatment

Trimix (papaverine, phentolamine, and prostaglandin E1) is highly efficacious, with 60% to 90% of men in various populations reporting excellent results (based on more than 10 studies).

Rapid onset

Trimix injections work quickly, typically with an erection becoming evident within about 5 to 15 minutes. The erection duration is typically 30 to 60 minutes.

Low risk of systemic effects

Trimix penile injections deliver medication directly to the penis, which decreases the risk of systemic side effects such as nausea, stomach cramps, and a rapid drop in blood pressure. Trimix use is usually not affected by diet or alcohol use.
What do patients say about Invigor Medical
  • Trimix

    Just N

    This process was one of the easiest. From the time of purchase to completing the medical forms and receiving a phone call, it was less than an hour. They were easy to understand, knowledgeable, and allowed me time to ask questions. I left the phone call feeling confident about what to expect and the timeframe of events.
  • Trimix

    Joselys P

    My experience was great! They called me and explained everything I needed to know regarding Semaglutide and the whole process. Very comforting experience.
  • Trimix

    Jeremiah S

    I have been a patient of Invigor Medical for about 2 years, and I have always received prompt responses from everyone, from salespeople to physicians… I just refilled my medication today, and it took about 5 text messages to get it taken care of. Thank you for helping me grow older without getting old.
  • Trimix


    I love Invigor Medical! They have the best customer service ever and wonderful products. Highly recommend this company!!!
  • Trimix

    OKC Couple

    I’ve been a client of Invigor Medical for several years and always have top notch service. They don’t make you feel weird about the products or any questions you might have. I just did another refill, Kristine C. helped my out and everything took just a few minutes and we were all set. Thank you again!!
  • Trimix

    Carl S

    Super easy to work with, I received a helpful call a few minutes after submitting my initial request and thry answered all my questions. So far so good!
  • Trimix

    Jeff K

    Brooklyn has been my point of contact and she has been really great to work with! She is responsive, caring, easy to work with, and friendly! Definitely recommend!
  • Trimix

    Mario C

    Always super knowledgeable about all their peptides and other offerings. Great customer service as well!
  • Trimix

    Michelle R

    I’ve never ordered medication this way but I’ve been pleasantly surprised with the ease of the process. Brooklyn has been amazing in helping me to navigate ordering and decide which medications I should discuss with the provider.
  • Trimix

    Mark E

    I have been working with Invigor Medical for about a year now. Kudos to Aryanna for doing a very good job. She helps me get my order approved, offers options, and my order is correct and shipped out efficiently. I recommend this company.
  • Trimix

    Jonathan M

    I have been working with Invigor Medical for several months, and find their service to be excellent. Today I was contacted by Courtney, who was checking in to see how things were going. She was very nice and helped me to save money on my semaglutide injections by switching to a 2 month subscription. Thank you Courtney! You were so kind and helpful.
  • Trimix

    Jen R

    **UPDATE** IT’S THE REAL THING! Semaglutide order arrived within a week. All supplies included with very thorough instructions. Extremely noticeable reduction in appetite. Will DEFINITELY buy from Invigor again!
  • Trimix


    A fantastic organization! Great customer support from the beginning to the end of the process. However, I must highlight one in particular who went above and beyond Brooklyn. She kept me informed and in the know of my order. I appreciate the extra mile at every stage. I would recommend them unreservedly.
  • Trimix

    Guido M

    Everyone I have dealt with here has been helpful, respectful, and hard working. Particularly treatment specialist Melissa – making sure that I get the assistance I need. It has been a very pleasant experience.
  • Trimix

    Murrell S

    They were nice, helpful and fast. The service rep that helped me was awesome!
  • Trimix

    Lacey H

    Katie was super helpful and knowledgeable when placing a refill order. She processed the order within a few mins via the chat option. Very easy! Have ordered several times and it’s always been super easy and very reliable! Sign up for the auto-fill, it makes things super nice!!
  • Trimix

    Steven C

    Exceptional service from this company. I had a few questions so I contacted Them via web chat on their website. Right after I ended the chat I was very surprised to have received a call from Aryanna, one of the staff there. She was sweet, polite, informative and was able to answer every concern I had ended the chat with. So far my experience here has been excellent.
  • Trimix

    Florenda B

    I highly recommend this business! They are reliable, honest, and operate with integrity. Their products are consistently outstanding, and they constantly exceed my expectations, every time I purchase from them! So, it should go without saying that their customer service is second to none!

    How to use Trimix

    Inject Trimix as directed into the mid-shaft of the penis, about 20-30 minutes before sexual activity.

    Common Side Effects

    • Pain or discomfort at the injection site
    • Bruising or bleeding at the injection site
    • Swelling at the injection site
    • Erection lasting more than four hours (priapism)
    • Infection due to poor injection technique
    • Difficulty ejaculating
    • Allergic reactions

    What’s Included

    • Rx Consultation
      Discuss your treatment plan with one of our licensed practitioners.
    • Supplies
      All medications and supplies included, no hidden fees.
    • Support
      Our well-trained medical staff are ready to answer your questions.


    This test detects endotoxins (remnants of bacterial cell walls that can cause serious health problems) in pharmaceutical products. It helps ensure that medications are not contaminated by bacteria. Endotoxin limits are set based on how the medication is administered.

    pH Test

    This test measures the percent hydrogen (pH) or acidity or alkalinity of a product. The pH can affect the medication’s stability, solubility, and potency. To ensure the validity of the endotoxin test, the pH must be kept in a specified range.

    Sterility Test

    This test confirms that all sterile compounded medications are free from microbial contamination, including bacteria and fungi. Sterility testing reduces the risk of infections from taking medications.

    Potency Test

    This test measures the strength or the concentration of an active pharmaceutical ingredient (API) over time. It can be used in conjunction with stability testing to ensure that the medication will retain its potency until its beyond-use date.

    Invigor’s Commitment to Quality Medication

    Our partner compounding pharmacies work with a registered and certified third-party lab to run quality control checks for every lot of compounded medications prescribed and delivered to our patients. These labs follow guidelines to ensure compounded medication safety and quality.

    Invigor’s Commitment to Quality Medication

    Our partner compounding pharmacies work with a registered and certified third-party lab to run quality control checks for every lot of compounded medications prescribed and delivered to our patients. These labs follow guidelines to ensure compounded medication safety and quality.


    This test detects endotoxins in pharmaceutical products to prevent contamination by bacterial remnants, ensuring medication safety. Limits are set based on administration methods.

    pH Test

    This test assesses a product’s pH, which impacts stability, solubility, and potency. Maintaining pH within a specified range ensures the validity of the endotoxin test.

    Sterility Test

    This test ensures sterile compounded medications are free from microbial contamination, minimizing infection risks.

    Potency Test

    This test assesses the potency of an active pharmaceutical ingredient (API) over time, ensuring medication retains potency until its expiration date.

    Get started with Trimix


    Choose a treatment plan

    Most of our patients know that what they need is just a few clicks away. Clients start by choosing a treatment plan that best suits their needs.

    Fill Out Medical Forms

    After choosing a treatment plan, it only takes a moment to fill out a medical history form so our physicians have all of the info needed to get you going.


    Provider Review

    Your order will be evaluated by a practitioner licensed in the state you reside. If they have any further questions they will contact you via email, messaging, or phone.


    Prescription Fulfilment

    One of our partnered, U.S. based, registered pharmacies will dispense and ship the medication straight to your door.

    Frequently Asked Questions about Product
    How many units of Trimix should I take?

    Trimix dosage can vary widely from person to person, and several variables help your doctor determine a good starting point. Most patients start by using around five units of TriMix and then increase the dosage in small increments each time until a hard, sustained erection is achieved.

    How often can I use Trimix injections?

    Most men can inject Trimix up to three times per week, with 24 hours between each injection. Injecting more often than this can cause penile scarring.

    Does Trimix work better than Viagra?

    Trimix is more effective than Viagra based on the percentage of men who report that their ED is improved. The success rate for Trimix is 80% to 95%. Viagra is around 60% to 70% effective for men with moderate ED.

    More men use Viagra than Trimix because taking a pill is easier than doing a penile self-injection. However, men using Trimix report that the injection procedure is nearly painless, and the results are fast and consistent.

    Many men, especially those taking medications for heart disease, cannot take Viagra or other medications in that class. For these men and men who want an ED treatment option that is unaffected by diet or alcohol consumption, Trimix is a great option.

    Are injections better than pills for ED?

    The American Urological Association recommends a process of shared decision-making when deciding which treatment option to use for ED.

    Men should be offered a full range of treatment options. Some men have medical conditions or are taking medications that keep them from taking ED pills. For these men, ED injections are a highly effective option.

    Do Trimix injections lose effectiveness?

    Trimix may not work for all men, including men with the following conditions:

    • Penile scarring
    • Peyronie’s disease
    • Poorly controlled diabetes
    • Dialysis-dependent kidney disease
    • Severe venous leak syndrome

    Talk to your healthcare provider if Trimix does not work for you. You may need a dosage change. They may also need to review your injection technique to ensure the medication is being delivered into the corpora cavernosa. Also, check the expiration date on your Trimix and ensure that you are storing it correctly.

    What is the difference between Trimix and Caverject?

    Trimix is a combination of three medications that work synergistically to increase blood flow into the penis and produce an erection. The three medications in Trimix are:

    • Prostaglandin
    • Papaverine
    • Phentolamine

    Caverject only contains prostaglandin.

    What happens if you inject Trimix too often?

    Trimix should always be injected following your healthcare provider’s instructions. If Trimix is injected too frequently or at too high a dose, it could cause priapism.

    Priapism is an erection that lasts longer than four hours. A prolonged erection allows blood to sit in the penis for too long. Fresh blood is needed to replenish oxygen and nutrients and remove waste products. Untreated priapism can damage the penis.

    How often can I inject Trimix?

    It is important to follow the instructions provided by your healthcare provider and pharmacist.

    In general:

    • Trimix should never be injected more than once in a 24-hour period.
    • Trimix should not be injected for more than two consecutive days.
    • Trimix should not be injected more than three times in one week.
    How is Trimix stored?

    Trimix must be stored refrigerated at 36°F–46°F. Extra Trimix vials can be frozen. Keep Trimix away from light and extreme temperatures. Discard expired medication properly.

    Detailed storage instructions are usually included with your Trimix prescription, as they may vary between compounding pharmacies.

    Who should not use Trimix?

    Those with a known hypersensitivity to Trimix or any of its components, sickle cell disease, sickle cell trait, multiple myeloma, leukemia, or other blood disorders, a penile implant or prosthesis, penile scarring or anatomical deformities, or a history of priapism should not take Trimix. Don’t take Trimix if you take blood thinners.

    Can you take Trimix with oral ED medications?

    Trimix should not be used in conjunction with other ED therapies without consulting with your healthcare provider.

    Sometimes, they are used together, but doing so increases the risk of side effects.

    Do I need a prescription before I buy from Invigor Medical?

    No, Invigor Medical employs doctors licensed in all 50 states, and a medical consultation is included with each medical service. Each patient will receive a valid prescription, which is sent to the pharmacy to be filled.

    How long does it take to get my medication?

    Once you have enrolled for medical services with Invigor Medical, it usually takes 7-14 business days before items arrive at your home. This process includes an online medical consultation, prescription approval, the medication getting filled at the pharmacy, and the medication being sent to your home.

    Trimix Overview

    Trimix is a highly effective injectable used to treat erectile dysfunction (ED). Trimix is a compounded medication with three active ingredients: alprostadil, phentolamine, and papaverine. It is only available by prescription.

    All three medications in Trimix synergistically widen blood vessels, increasing blood flow into the penis, resulting in a firm and long-lasting erection. According to clinical studies, 87% to 93% of men who use Trimix are satisfied with the results. Lower medication doses can be used when medications are combined in Trimix, resulting in fewer side effects.

    Trimix is injected directly into the penis using a very small needle. When used properly under medical supervision, injectable ED medications have been safe ED treatment options for over 40 years. Trimix provides an excellent solution for men who do not get optimal results from oral ED medications.

    What is Trimix?

    Why do Patients Love Trimix?

    Patients who get Trimix shots from Invigor Medical experience consistent results. Three important benefits are listed below.


    Trimix has been shown to be nearly 95% effective in treating erectile dysfunction.


    In as little as 5 to 15 minutes, Trimix users can get an erection firm enough to perform sexual activities.


    Trimix injections can make an erection firm and long-lasting enough for sexual penetration.

    Trimix is a Combination of Three Medications That Increase Blood Flow into the Penis

    Trimix is an injectable ED treatment option. It is a compound made up of three medications: phentolamine, papaverine, and alprostadil (prostaglandin E1)

    It is an excellent ED treatment alternative for men who can’t or don’t want to take oral ED medications, have had severe side effects, or haven’t had successful results when taking oral ED medications.

    The three medications in Trimix work together to increase blood flow to the penis. Based on clinical studies, the success rate for Trimix when treating ED approaches 95%.

    According to the American Urological Association, 53.7% to 100% of men (depending on the population) achieved a satisfactory erection with Trimix, and 46.3% to 98.8% of men were happy with their choice to use intracavernosal injections as a treatment option.

    Other Injectable ED choices

    Although Trimix is a frequently prescribed injectable to treat ED and is highly effective, it is not the only option.


    Bimix is a combination of phentolamine and papaverine. It is an excellent choice for men with sensitivity to prostaglandin E1 or who have health conditions that contraindicate its use.


    QuadMix combines phentolamine, papaverine, atropine, and alprostadil (prostaglandin E1). Trimix is up to 95% effective in treating ED. If you are among the other 5% of men, Quadmix may be a great option.

    The Science of Trimix

    An erection occurs through a complex physiological process requiring coordination between the brain, hormones, nerves, blood vessels, and penile tissues. An erection occurs when blood flows into the spongy tissue in the penis and becomes trapped in spaces known as the corpora cavernosa. As blood fills these chambers, pressure builds, causing the penis to stiffen. 

    Trimix is a combination of three medications: phentolamine, papaverine, and prostaglandin E1 (alprostadil).


    The alpha-adrenergic antagonist phentolamine relaxes the smooth muscle lining the spongy tissue in the penis. This allows blood to flow into the penis, leading to a firmer erection.


    Papaverine, one of the first injectable medications used to treat ED, is a vasodilator, which means that it dilates blood vessels and increases blood flow into the penis. Papaverine is no longer used to treat ED on its own. It is used in conjunction with phentolamine and prostaglandin to improve ED treatment outcomes while minimizing side effects.

    Prostaglandin E1 (alprostadil) 

    Prostaglandin E1 relaxes smooth muscle surrounding blood vessels in the penis and the spongy tissue in the penis, allowing them to fill with blood. Blood becomes entrapped in the penis, which leads to an erection. Pellets inserted into the urethra or by penile injection are two ways to administer prostaglandin.

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