Improves erectile function

In one study, men had a 59% success rate achieving penetrative sex 36 hours after taking tadalafil, compared to a 28% success rate in the placebo group. At 24 hours after tadalafil dosing, 52% of men taking tadalafil had successful intercourse attempts, compared to 29% with placebo. In another study, 84.5% of men taking tadalafil reported improved erections and about half reported no ED symptoms.

Improves premature ejaculation

Premature ejaculation (PE) is defined as ejaculation with minimal sexual stimulation before or shortly after penetration, resulting in anxiety and distress. In one small study, tadalafil 5 mg reduced ED symptoms and delayed ejaculation. Another study followed men with erectile dysfunction (ED) and PE for 2 years and confirmed tadalafil continued to alleviate ED and PE symptoms.

May reduce cardiovascular disease risk

In a large study of over 20,000 US men with ED, PDE5i exposure (oral ED medications such as tadalafil) was associated with lower incidence of major adverse cardiovascular events (13% lower), cardiovascular related death (39% lower), and overall mortality risk (25% lower) compared to non-exposure. Higher PDE5i dosages were associated with lower risk of cardiovascular disease and death.