PT-141, also known as bremelanotide, is used to treat sexual dysfunction and low libido in men with erectile dysfunction (ED) and women with hypoactive sexual desire disorder (HSDD). In 2019, the U.S. Food & Drug Administration approved Vyleesi, bremelanotide, to treat HSDD in premenopausal women after reviewing clinical trial results that demonstrated medication safety and effectiveness.
Bremelanotide, PT-141, has since been explored as a treatment for men with decreased libido and ED. Manufacturers have not sought FDA approval for PT-141 use in men. PT-141 can be prescribed “off-label” for men based on the safety and efficacy trials that have been completed.
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How Does PT-141 Work?
PT-141 is a synthetic peptide that works similarly to the natural hormone melanocortin. It appears to bind to melanocortin receptors 3 and 4 in the brain and increases arousal and penile erections by releasing dopamine, a neurotransmitter in the brain.
Initially, PT-141 was developed to increase skin pigmentation and tanning. Increased sexual desire and better erectile function were noted as side effects during clinical testing. In men, PT-141 improves erectile function and promotes sexual desire. Unlike oral ED medications that increase blood flow into the penis, PT-141 works in the brain to increase sexual desire.
In a double-blind placebo-controlled study, approximately 80% of men developed an erection satisfactory for intercourse after using PT-141, whether the cause of ED was physical or psychological, and 68% of men reported an increase in sexual desire. Additionally, PT-141 has shown effectiveness in treating ED in men with diabetes or who do not respond to sildenafil.
How Does PT-141 Work For Women?
PT-141 has been studied for its potential use in treating HSDD in premenopausal women. HSDD is characterized by a persistent lack of sexual desire that causes distress. Based on DSM-5 criteria, HSDD can be diagnosed when women notice a decrease in three or more of the following and are distressed by these symptoms:
- Sexual or erotic fantasies or thoughts
- Interest or arousal in response to erotic stimuli, whether internal or external
- Interest in sexual activity
- Pleasure or excitement during sexual activity (3/4 of the time)
- Genital or non-genital sensations (3/4 of the time)
- Initiating sexual activity or responding when a partner initiates sexual activity
Before using PT-141, women should meet with a healthcare professional potential to discuss any concerns they have regarding side effects, interactions with other medications, and impact on any pre-existing health conditions that may be impacted by its use.

What Are PT-141’s Benefits?
PT-141 is a proven treatment for ED and low libido, but its potential benefits can go beyond improving sexual function. The most notable benefits associated with PT-141 treatment include:
- Increased libido;
- Increased sexual function;
- Better erectile function;
- Elevated mood;
- Reduced sexual anxiety.
Like all medications, PT-141 affects different people in different ways, and not everyone will experience the same set of benefits. Additionally, patients may experience negative side effects when taking PT-141, which can vary.
What Are PT-141’s Side Effects?
Anyone who is currently taking or considering PT-141 should be aware of its potential side effects. Fortunately, many common side effects associated with PT-141 are considered mild to moderate. These side effects may include:
- Nausea;
- Vomiting;
- Headaches;
- Flushing;
- Redness, pain, irritation, and bumps at the injection sites.
When used long-term (52 weeks), nausea (40%) was the only severe adverse event noted in a study of 272 female patients taking PT-141. Flushing (21%) and headaches (12%) were also observed.

These relatively mild side effects make PT-141 a potentially safer alternative to other popular ED treatments like Sildenafil (Viagra), which is associated with an increased risk of heart attack and stroke in some patients. However, there are several rarer side effects of PT-141 that patients must be aware of, including:
- Blurred vision;
- Dizziness;
- Nervousness;
- Pounding in the ears;
- Cough;
- Stuffy nose;
- Tiredness;
- Tingling feeling in fingers and toes;
- Increased heart rate;
- Darkening of the gums or skin.
People with uncontrolled high blood pressure or known cardiovascular disease should not take PT-141 because the medication increases blood pressure and reduces heart rate after each dose.
You should seek immediate medical care if you display any signs of an allergic reaction to PT-141, such as hives, respiratory distress, and swelling of the face, lips, throat, and tongue.
Can You Take PT-141 Daily?
PT-141 is injected subcutaneously or taken intranasally. Inject at least 45 minutes before anticipated sexual activity. According to the recommended dosage, administering more than one dose in 24 hours or more than eight doses per month is not recommended.
Injecting too many doses or injecting doses too close together doesn’t improve efficacy and may increase potential side effects. If you’re currently taking PT-141, be sure to follow the instructions on your medication insert, and if you have questions, please get in touch with your doctor or pharmacist.

How Long Does PT-141 Last?
The half-life of PT-141 is 2.7 hours. It typically takes effect within 30 minutes to several hours after administration. However, medications are metabolized at different rates in each person. In some cases, people who have taken PT-141 report that they notice the effects for up to 24 hours.
It’s important to note that while the peak effects may be felt within a few hours, the overall impact in terms of arousal and desire can linger for a longer period, making it a useful option for those seeking to boost sexual function.
Where Can You Learn More About PT-141?
If you’re seeking to enhance your sexual health and experience with proven solutions, PT-141 injections could be a significant game-changer. Offering a unique mechanism that targets the brain to improve sexual desire and function, PT-141 stands out as an innovative option for those facing challenges in their sexual wellness.
Individuals interested in exploring the potential of PT-141 injections should buy PT-141 injections from trusted providers like Invigor Medical to ensure access to quality, safety, and efficacy. Learn more about how PT-141 injections can transform your sexual health journey at Invigor Medical.