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Enclomiphene blocks estrogen receptors in the brain. This enables the pituitary gland to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH) even as testosterone levels increase in the body.
Enclomiphene works with your body’s natural feedback loops to boost your testosterone levels while preserving your fertility.
No, enclomiphene is not a steroid. It is a non-steroidal selective estrogen receptor antagonist. It blocks the effects of estrogen and increases testosterone production.
Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.
When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.
The FDA stated that the design of the enclomiphene phase 3 studies was no longer adequate to show clinical benefit. They showed that enclomiphene increased testosterone levels but did not show how an increased testosterone level provided benefits such as increased muscle strength, improved sexual function, and decreased fatigue.
No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.
It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.
In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.
Yes, enclomiphene can increase your hematocrit (the proportion of red blood cells in your bloodstream) and your risk for venous thromboembolism (blood clots).
These are known risks when increasing testosterone levels. Have your hematocrit checked before starting enclomiphene and periodically after you begin taking the medication.
If you have a family history of blood clots or risk factors for blood clots, discuss this increased risk with your doctor.
No, enclomiphene is an alternative to TRT.
Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with hypogonadism.
Hypogonadism is a condition in which the testes do not produce enough testosterone. It is diagnosed in men with symptoms that are consistent with low testosterone levels and documented morning testosterone levels below 250 to 300 ng/dL.
Yes, obesity and being overweight are linked to low testosterone levels. Body fat contains aromatases that convert testosterone to estrogens.
When estrogen levels increase, they reduce FSH and LH release. FSH and LH are essential for testosterone production and sperm maturation. When FSH and LH levels decline, testosterone production does as well.
*Prescription medications available only if prescribed by the healthcare provider after an online consultation. This is a compounded medication.