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Can You Take Too Much Vitamin B12?

Last Updated: August 29, 2025
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Vitamin B12, also known as cobalamin due to its cobalt content, supports key bodily functions, including the production of red blood cells and DNA. It’s also important for digestion, metabolism, and nervous system support.

Humans get B12 naturally from animal products like red meat, poultry, fish, eggs, and dairy. However, sometimes we don’t get enough. A B12 deficiency can lead to several problems, including fatigue, weakness, anemia, and, in severe cases, nerve damage.

An overdose of vitamin B12 is rare if you take supplements according to the recommended dosage and eat a balanced diet. However, recent studies suggest that extremely high doses might cause adverse effects. For instance, a 2020 case report describes a patient experiencing skin issues, anxiety, and insomnia after receiving high oral B12 doses. 

More research is needed to determine the exact threshold for B12 toxicity, but it highlights the importance of consulting a healthcare professional before taking megadoses of any supplement. Here is a closer look at managing your use of vitamin B12.

Written by

Derek Berkey
Derek Berkey
CEO, Invigor Medical | Science-Based Wellness Expert
Derek Berkey is the Chief Executive Officer of Invigor Medical, a telehealth company specializing in weight management, sexual health, and healthy aging. He serves as an author and reviewer, ensuring all content is grounded in science-based, patient‑centered insight.

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Derek Berkey
Derek Berkey
CEO, Invigor Medical | Science-Based Wellness Expert
Derek Berkey is the Chief Executive Officer of Invigor Medical, a telehealth company specializing in weight management, sexual health, and healthy aging. He serves as an author and reviewer, ensuring all content is grounded in science-based, patient‑centered insight.

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