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Compounded Semaglutide with B12: Added Benefits

Mar 20, 2024
Compounded Semaglutide with B12: Added Benefits

Compounded semaglutide with B12 fills the gap between the enormous demand for anti-obesity medications and the ability of pharmaceutical manufacturers to meet the demand. Compounded medications can be personalized to meet the needs of individual patients. Many compounding pharmacies compound semaglutide with B12 to boost energy and combat some of semaglutide’s known side effects, including nausea and vomiting.1

Nausea and vomiting are the top reasons people stop taking semaglutide, whether to treat type 2 diabetes or obesity. In this 2018 study, researchers reported that conjugating B12 to GLP-1 agonists such as semaglutide blocks these drugs from entering the part of the brain that triggers fatigue and nausea.2

Semaglutide: A Powerful Weight Loss Tool

Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist that was initially approved as a treatment for type 2 diabetes. It helps regulate blood sugar levels by stimulating insulin release from the pancreas and reducing glucagon secretion.

In addition to treating type 2 diabetes, semaglutide is a very effective treatment for obesity. It mimics the effects of GLP-1, a hormone naturally produced and released from your intestines after consuming a meal. GLP-1 hormone binds to receptors throughout the body. GLP-1 receptors are found on pancreatic beta cells to release insulin and lower blood sugar.  GLP-1 agonists bind to their receptors on the stomach lining to slow stomach emptying, which leads to feelings of fullness. GLP-1 receptors are also found in the kidney, heart, and hypothalamus, a part of the brain that regulates satiety, food cravings, and hunger.3

Studies have shown that semaglutide can reduce hunger, increase satiety, and reduce food cravings, in addition to improving blood sugar control. In the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trials, people taking semaglutide lost an average of 14.9% to 17.4% of their body weight over 68 weeks.4 The most significant weight loss benefits were observed when semaglutide was used in combination with lifestyle changes, such as a healthier diet and regular exercise.

Semaglutide is an effective weight-loss medication for people with or without diabetes.

Infographics Semaglutide

The Vital Role of Vitamin B12

Vitamin B12, also known as cobalamin, plays a crucial role in various bodily functions. It supports brain function, including memory and mood, immune system health, DNA production, and oxygen transport throughout the body by maintaining red blood cell health.

Vitamin B12 is essential to convert carbohydrates from your diet into energy that your body can use. A reduced-calorie diet can increase fatigue. Vitamin B12 supplementation can improve carbohydrate usage and energy levels in people with vitamin B12 deficiency.

The Benefits of Compounded Semaglutide with B12

Compounded semaglutide with B12 offers a range of benefits beyond weight loss and blood sugar control. Let’s explore some of these potential advantages:

1. Physical Functioning

Weight loss can improve physical function and mobility. In the STEP clinical trials, researchers reported that people taking semaglutide for weight loss had an improved quality of life as they became more physically mobile and increased their physical activity throughout the day.5

2. Inflammation

Carrying excess adipose or fat tissue leads to increased inflammation. Chronically elevated inflammation can increase your risk of cardiovascular disease, abnormal lipids, type 2 diabetes, high blood pressure, and metabolic syndrome.6 Compounded semaglutide with B12 can induce significant weight loss and reduce inflammation.

3. Mental Health

Obesity is associated with mental health conditions such as anxiety, sleep disorders, low self-esteem, depression, and eating disorders. Widespread beliefs that obesity and overweight are due to a lack of personal willpower contribute to weight stigma and discrimination. This increases the risk of mental and physical health conditions.5,7 Obesity is a chronic disease, and compounded semaglutide with B12 is an effective treatment for this disease.

weight loss map

4. Satiety and Cravings

In the STEP 5 clinical trial, treatment with semaglutide resulted in better craving control and a more positive mood. Participants taking semaglutide reported reduced cravings for savory and sweet foods when compared to participants taking a placebo.5

5. Cardiovascular Benefits

Cardiovascular health is a critical aspect of overall well-being. Semaglutide has shown cardiovascular benefits by reducing the risk of major adverse cardiovascular events in people with or without type 2 diabetes (SELECT clinical trials). These benefits include a 20% lower risk of heart attacks, strokes, and cardiovascular-related deaths over 40 weeks.8 Semaglutide use also resulted in significant fat loss and improved body composition.

On March 8, 2024, the U.S. Food & Drug Administration approved a new indication for Wegovy (semaglutide). It can be used to decrease the risk of cardiovascular death, heart attack, or stroke in adults with cardiovascular disease and either obesity or overweight. A lower-calorie diet and increased exercise should go hand in hand with using semaglutide to lower the risk of cardiovascular disease.

6. Sleep Apnea

Obstructive sleep apnea is a serious condition that can cause you to pause your breathing at night. This can reduce your lung function and interrupt your sleep. Obesity and overweight are associated with an increased risk of sleep apnea. Excess fat tissue in the face and neck can compromise your airway at night when your muscles are more relaxed.

Semaglutide can reduce body weight and, therefore, reduce the risk of sleep apnea. Researchers have found that obstructive sleep apnea is also associated with lower GLP-1 levels.9 Semaglutide, a GLP-1 receptor agonist, works just like natural GLP-1 in your body. Increasing GLP-1 can induce weight loss and potentially reduce the risk of sleep apnea.

A doctor answering a question

How to Use Semaglutide and B12 Compound

Using compounded semaglutide with B12 is a straightforward process. Here are the key steps to follow:

1. Administration

Semaglutide compounded with B12 is administered as a subcutaneous injection. The recommended starting dose is typically 0.25 mg subcutaneously once a week. After one month of treatment, the semaglutide dosage may be increased to 0.5mg once a week if needed, up to a maximum dose of 2.4 mg. It’s essential to follow the instructions provided by your healthcare provider and ensure proper injection technique for optimal results. If you have questions about dosage, a missed dose, or how to inject semaglutide, contact your healthcare provider.

2. Lifestyle Modifications

To maximize the benefits of semaglutide compounded with B12, it’s crucial to incorporate lifestyle modifications. This includes adopting a nutritious, reduced-calorie diet and maintaining regular physical activity. These lifestyle changes, combined with semaglutide’s ability to regulate appetite, reduce cravings, and quiet food noise, can lead to substantial weight loss.

3. Ongoing Monitoring and Support

Regular monitoring and follow-up appointments with your healthcare provider are essential throughout your compounded semaglutide and B12 treatment journey. They will assess your progress, adjust dosages if needed, and provide guidance and support to help you achieve your weight loss and glycemic control goals.

Considerations and Side Effects When Taking Semaglutide B12 Compound

While compounded semaglutide with B12 offers numerous benefits, it’s essential to be aware of potential side effects and considerations. Here are some important points to keep in mind:

1. Nausea and Gastrointestinal Distress

Nausea, vomiting, diarrhea, stomach pain, and constipation are the most commonly reported side effects of semaglutide. These symptoms are typically mild to moderate in intensity and tend to improve over time. If you experience persistent or severe side effects, it’s important to consult your healthcare provider for further guidance. You may need to decrease your semaglutide dose or change to a different medication.

2. Hypoglycemia and Kidney Problems

Individuals at risk of hypoglycemia or with pre-existing kidney problems should exercise caution when using semaglutide B12 compound. Close monitoring of blood sugar levels and kidney function is crucial to ensuring safety and optimizing treatment outcomes.

3. Allergic Reactions

While rare, allergic reactions to semaglutide or B12 are possible. If you experience symptoms such as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek immediate medical attention.

4. Other Potential Side Effects

Other potential side effects of semaglutide compounded with B12 include fatigue, indigestion, excessive gas and sulfur burps, and injection site reactions. Gallbladder disease and pancreatitis can occur in some people at increased risk of these conditions. Semaglutide also carries a boxed warning for thyroid tumors. This rare side effect was noted in animal studies, but whether humans also carry an increased risk is unclear. If you have a history or a family history of medullary thyroid cancer or multiple endocrine neoplasia (MEN) type 2, you should not take semaglutide.


Compounded semaglutide with B12 offers a personalized and effective solution for weight loss and blood sugar control that also reduces the risk of cardiovascular disease in people with overweight and obesity. By harnessing the power of semaglutide’s weight-loss potential and the fatigue and nausea-reducing properties of vitamin B12, semaglutide compounded with B12 shows great promise in helping people who have overweight or obesity achieve their weight-loss goals and improve their health.  

It’s crucial to work with a knowledgeable healthcare provider when taking semaglutide, undergo regular monitoring, and adopt lifestyle changes to optimize compounded semaglutide with B12’s weight loss benefits and reduce potential side effects.

If you have a body mass index (BMI) of 30 or higher or have a BMI of 27 or higher along with a weight-related medical condition and are interested in learning more about the potential benefits of semaglutide for weight loss and cardiovascular health, contact an Invigor Medical treatment specialist to get compounded semaglutide with B12.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

Compounded Semaglutide with B12: Added Benefits

Leann Poston, M.D.

Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.


  • Borner T, Shaulson ED, Tinsley IC, Stein LM, Horn CC, Hayes MR, Doyle RP, De Jonghe BC. A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models. Diabetes Obes Metab. 2020 Oct;22(10):1729-1741. doi: 10.1111/dom.14089. Epub 2020 Jun 25. PMID: 32410372; PMCID: PMC7927944.
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  • Bergmann NC, Davies MJ, Lingvay I, Knop FK. Semaglutide for the treatment of overweight and obesity: A review. Diabetes Obes Metab. 2023;25(1):18-35.
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