Sermorelin: A Comprehensive Guide to an Anti-Aging Peptide

April 19, 2024
Man working out in the gym in push up position

Aging, an inevitable journey for all, is not a disease but a natural process that brings its own set of challenges. That does not mean that we have to passively accept the outcomes of aging. Anti-aging peptides could help slow the aging process. One such promising therapy is sermorelin.

Sermorelin is a synthetic form of growth hormone-releasing hormone (GHRH) that stimulates your pituitary gland to produce more naturally produced growth hormone (GH). Sermorelin does not replace or add to growth hormone; instead, it supports natural GH production in order to restore optimal levels.

By restoring optimal levels of human growth hormone (HGH), sermorelin offers a range of potential benefits, from increased energy and vitality to improved physical performance and overall well-being.

As anti-aging peptide research evolves and yields breakthroughs, it is essential to understand the function and impact of these treatments. This includes weighing the potential risks of sermorelin against its benefits to make an informed decision on whether to use this treatment.

In this article, learn more about the science behind sermorelin therapy, its potential benefits, and considerations to keep in mind when evaluating whether sermorelin supplementation aligns with your personal health and anti-aging goals.

“Aging is not a disease. Rather, it is a physiological state of relative GH deficiency.” Hersch and Merriam (1)

Symptoms of Adult Growth Hormone Deficiency

Low growth hormone levels in adults can cause the following symptoms (1-3):

  • Increased body fat, especially abdominal fat
  • Decreased lean body mass
  • Decreased muscle strength
  • Decreased exercise performance
  • Decreased bone mass
  • Decreased red blood cell volume
  • Unhealthy blood lipids
  • Thin, dry skin
  • Depression and anxiety
  • Fatigue
  • Sleep disturbances
Sermorelin: An Anti-Aging Peptide - Image of a man lifting a tractor tire

Understanding Sermorelin: What is it and how does it work?

Sermorelin mirrors the structure and function of a naturally occurring substance in the body that stimulates the pituitary gland to produce and release growth hormone. Sermorelin’s structure includes the first 29 amino acids of GHRH. In the 1970s, Nobel Laureates R. Guillemin and A. Shalley recognized this significant amino acid sequence as being essential for causing HGH release from the pituitary gland.

Sermorelin can bind to GHRH receptors in the anterior pituitary gland because its structure is similar to that of natural GHRH. Upon binding, it induces the gland to release endogenous growth hormone, harnessing the body’s natural processes for maintaining and regulating growth hormone levels.

The German pharmaceutical company EMD Serono initially developed sermorelin to treat growth hormone deficiencies in both children and adults (4). It gained U.S. Food and Drug Administration approval in 1997 under the brand name Geref. Strong clinical trial data supported Geref’s efficacy and safety in treating growth hormone deficiency.

Despite its therapeutic potential, the commercial distribution of sermorelin under the brand Geref was discontinued in 2008. It’s important to note that this decision was driven by market factors and not because of safety or effectiveness concerns.

Growth Hormone Axis

The growth hormone axis plays a crucial role in the body, affecting a wide variety of body organs and tissues. In the brain, the hypothalamus releases GHRH into blood vessels that connect the hypothalamus with the pituitary gland. This gland is frequently called the master gland because of its far-reaching effects. 

When GHRH binds to receptors on the pituitary gland, it increases the production and secretion of growth hormone into the bloodstream. GH travels through the bloodstream to target organs, such as the liver.

When GH binds to its receptors in the liver and other body tissues, insulin growth factor-1 (IGF-1) is produced.

IGF-1 has anabolic effects on bone and muscle. It stimulates muscle cell division and growth and helps maintain bone density. 

IGF-1 also affects glucose and lipid metabolism and cell proliferation (5). IGF-1 helps regulate glucose transport across cell membranes. It also impacts how the body uses and stores glucose and fat. 

Image of a DNA strand on a screen with a microscope

Growth Hormone Regulation

Growth hormone-releasing peptides (GHRPs) such as ghrelin also stimulate GH release. Ghrelin is produced in the stomach. Ghrelin and GHRH have a synergistic effect on GH release (2).

Growth hormone is released in pulses, with the largest pulses occurring just before you enter deep sleep. Each of the approximately ten daily GH pulses lasts for about 90 minutes. With increasing age, the amplitude of each GH pulse decreases, with nighttime pulses affected more than daytime pulses (6).

Sermorelin acts like GHRH to prod the pituitary gland to produce and release GH. GH binds to receptors in the liver to increase IGF-1 production. 

This sets up a feedback loop. GH is released to increase IGF-1 production. When IGF-1 production reaches a certain level, it inhibits GH release. By keeping your body’s natural feedback loops intact, the risk of side effects from sermorelin is much lower than when using recombinant HGH (7).

Recombinant HGH replaces naturally produced GH. Like GH, it binds to GH receptors and stimulates IGF-1 release. IGF-1 suppresses natural growth hormone production but has no effect on recombinant GH. 

Somatostatin is another hormone produced in the hypothalamus. Somatostatin inhibits GH release by opposing the effects of GHRH. This system also provides checks and balances to stabilize GH levels.

Growth Hormone Deficiency

An inability to produce adequate growth hormone is typically diagnosed early in life. It may also occur in an adult as a result of surgery or a brain injury. Reduced GH production requires immediate medical attention and treatment. This differs greatly from age-related declines in GH release.

Growth hormone is essential for normal growth and development during childhood and adolescence, but it is also important to maintain healthy tissues and organs, increase exercise tolerance, enhance muscle strength, and maintain an optimal metabolism throughout your lifespan (8).

Around age 30, the body stops making as much growth hormone. This can cause a number of age-related symptoms, such as a loss of muscle mass and strength, a drop in bone density, an increase in body fat, worsening heart and blood vessel health, and longer recovery times after exercise (9).

Growth hormone studies in men show that GH levels decline by about 14% each decade. It may decline by as much as 50% every seven years for some adult men (9). In one study, about one in every three men over the age of 65 were GH deficient (10).

It is unclear why growth hormone levels decrease with age. Possibilities include(2):

  • Decrease GHRH secretion
  • Decreased ghrelin secretion
  • Increased sensitivity to somatostatin
  • Increased sensitivity to negative feedback from IGF-1
  • A decrease in pituitary sensitivity to GHRH
Man preparing to do a dead lift in the gym

Recombinant Human Growth Hormone (HGH) vs. Sermorelin

Research has indicated that replacing HGH is detrimental to overall health, except for people with a documented growth hormone deficiency. Excessively high levels of GH can promote, rather than prevent, aging (11).

In the United States, HGH is legal only as a prescription medication to treat specific medical conditions. According to the Code of Federal Regulations, it is illegal to possess or distribute HGH for any uses other than those that have received approval and only when a doctor has prescribed it (7).

When injecting HGH, the levels circulating in the body are consistent and not controlled by a negative feedback system. They do not follow the natural circadian rhythm. With a constant GH level, GH receptors lose their sensitivity to GH.

A high level of HGH can increase the risk of acromegaly (enlargement of bones in the face, hands, and feet), cardiomegaly (enlargement of the heart), increased organ size, decreased muscle strength, abnormal nerve function, cells that turn cancerous, insulin resistance, and more oxidative damage at the cellular level (12).

Sermorelin acts by binding to specific receptors in the pituitary gland, stimulating the release of naturally produced GH. In contrast to HGH, sermorelin works with the body’s natural feedback systems to cause growth hormone to be released in pulses, similar to how the body normally works. 

This natural approach offers several advantages over traditional growth hormone replacement therapy. It avoids overdosing and tachyphylaxis, which occur when GH has reduced effectiveness (7). This occurs when GH receptors are exposed to chronically high GH levels.

Benefits of using growth hormone-releasing hormones, such as sermorelin, instead of growth hormones include:

  • Natural feedback loops are kept intact.
  • It is almost impossible to overdose because of feedback loops.
  • Growth hormone release remains episodic, which is its natural pattern.
  • Tachyphylaxis, or a tolerance to the effects of growth hormone, is avoided.
  • An increased production of GH is held in reserve.

Sermorelin and HGH work in different ways in the body. HGH can have serious adverse effects. There are many legal and health-related reasons to choose aermorelin over human GH.

Sermorelin Clinical Trials

There is not much current research testing sermorelin’s safety and effectiveness. This is likely because pharmaceutical companies are no longer applying to produce sermorelin as an approved medication.

However, several studies have been conducted that indicate that sermorelin is generally well-tolerated with few or no long-term side effects in people without medical factors that increase their risk of adverse effects.

In a 1990 study, healthy men over the age of 60 were treated with GH for six months. They experienced an 8.8% increase in lean body mass, a 14.4% decrease in fat mass, and a 1.6% increase in vertebral spine bone density (10).

The NIH National Institute on Aging used this study to push for more research on GH, either by itself or in combination with GHRH, sex steroids, IGF-1, or exercise conditioning, to learn more about how these things affect the aging process (2).

A man with lean muscle mass in black and white

GH Affects Body Composition

In a study enrolling 52 men over the age of 69 to receive either GH three times weekly for six months or a placebo, fat mass decreased by an average of 13.1% in the growth hormone group and 0.3% in the placebo group (13).

In a 26-week study that enrolled men and women aged 65 to 88 to receive GH and sex steroids, researchers discovered the following:

Lean body mass in women

  • Increased by 0.4 kg in the placebo group
  • Increased by 1.2 kg in the sex steroid hormone replacement group
  • Increased by 1.0 kg in the GH group
  • Increased by 2.1 kg in the GH and sex steroid hormone replacement groups

Lean body mass in men

  • Increased by 0.1 kg in the placebo group
  • Increased by 1.4 kg in the sex steroid hormone replacement group
  • Increased by 3.1 kg in the GH group
  • Increased by 4.3 kg in the GH and sex steroid hormone replacement groups

Researchers concluded that GH, with or without sex steroids, increased lean body mass. Women did not experience an increase in strength or cardiovascular endurance. Because GH (not GHRHs, such as sermorelin) was used, adverse effects were common (14).

In 2012, after analyzing 54 randomized controlled studies, researchers found that people who received GH therapy had a significant reduction in body fat and overall body weight and an increase in lean body mass (15).

A side profile of a woman with lean muscle mass

Sermorelin Increases GH Levels

Sermorelin was tested for its ability to increase GH levels. Researchers found sermorelin increased GH levels to the same magnitude as GHRH. Simultaneously, sermorelin increased follicle-stimulating hormone (FSH) and luteinizing hormone (LH), suggesting that sermorelin may also boost testosterone levels (6). However, more research is needed to substantiate this potential relationship between sermorelin and testosterone.

In another study, sermorelin supplementation increased GH and IGF-1 levels in older men. IGF-1 levels remained elevated above baseline for two weeks. This suggests that sermorelin can have long-lasting effects (16). Another GHRH, tesamorelin, was used in a similar study. Men who injected with tesamorelin daily for two weeks had increased mean overnight GH release, increased GH peaks, increased baseline GH secretion, and increased IGF-1 levels (17).

In another study conducted at the University of Washington, participants received daily injections of sermorelin, alone or in combination with exercise conditioning. IGF-1 levels rose by about 35%. Participants in the study experienced an increase in lean body mass and a decrease in fat, especially the more harmful abdominal fat. They did not experience an increase in strength or aerobic fitness. The effects of exercise and GH seem to work through different mechanisms. GHRH supplementation appears to stabilize, if not improve, physical function (6, 24).

Sermorelin and Cognitive Health

When 89 older adults were injected with sermorelin acetate daily for six months, they experienced significant improvement in several cognitive assessments, including problem-solving, psychomotor processing speed, and working memory. They did not note changes in other cognitive functions (18).

Anti-aging peptide research continues to advance the anti-aging field. More research is expected, especially since a 2017 literature review on the safety and efficacy of GHRH analogs such as sermorelin found that they “exhibit a broad safety profile (19).”

The Potential Benefits of Sermorelin Therapy

1. Increased Energy and Vitality

As we age, it is common to experience a progressive loss of strength and aerobic capacity. This can lead to a decline in energy levels and vitality.

A decrease in energy levels and muscular strength can make it harder to keep up with the demands of work, family, and personal pursuits, but it also increases your risk of falls and other health complications.

Restoring growth hormone levels using sermorelin can increase muscle strength and energy levels. As your body burns fat more efficiently for fuel, your endurance increases.

Research suggests that the aging pituitary may become less sensitive to stimuli such as exercise that increase growth hormone production. However, its sensitivity to GHRH and synthetic versions of GHRH does not change (1).

A woman running down the street

2. Improved Physical Performance and Exercise Tolerance

Exercise plays a crucial role in maintaining a healthy lifestyle and combating the effects of aging. However, as we age, our ability to engage in physical activity may decline due to factors such as reduced muscle mass, slower recovery, and decreased endurance.

Studies also suggest that exercising alone will not increase GH release as much as we get older. Supporting GH release with sermorelin can potentially increase the growth and function of skeletal muscle, support heart muscle function, improve blood cholesterol levels, and increase bone density.

Sermorelin therapy has been shown to enhance exercise performance by improving muscle strength, endurance, and recovery time. However, the effect is more marked in men. This is likely because estrogen decreases GH’s effect on IGF-1 production in the liver (2).

3. Enhanced Body Composition

Age-related changes in body composition, such as increased body fat and decreased muscle mass, can have a significant impact on our physical appearance and overall health.

Growth hormone therapy improves lean muscle mass, decreases body fat, and improves blood lipid profiles. It increases fat metabolism, glucose, and amino acid uptake and stimulates protein synthesis, leading to enhanced weight loss (6, 20).

Because HGH therapy is associated with serious risks and side effects, researchers turned their attention to GHRHs, such as sermorelin, instead. GHRHs have many of the same benefits as HGH therapy without the same adverse side effects or regulatory concerns (6).

Most research using sermorelin to improve body composition has been conducted in men with low testosterone levels. More research is needed to see if sermorelin has the same benefits in other populations.

To get the full benefits of sermorelin for weight loss, plan to take it for four to six months. Since sermorelin only supports your body’s natural GH production and this is only one factor in weight management, it is important to combine sermorelin therapy with a reduced-calorie diet and exercise to form a comprehensive weight-management plan.

4. Improved Cognitive Function and Mental Wellbeing

Sermorelin increases natural GH production. Restoring GH to optimal levels can improve cognitive function and mental well-being.

There is evidence that sermorelin treatment can lead to improvements in fluid intelligence, problem-solving, and cognitive skills. In one study, sermorelin treatment improved cognitive function regardless of gender, estrogen status, or baseline cognitive level. 

Researchers concluded that an age-related decline in GH may be linked to an age-related decrease in cognition. Supplementing with sermorelin may partially improve such cognitive declines in healthy older adults with normal cognitive function and maybe even in people with impaired cognitive function from Alzheimer’s disease (21, 22).

A woman getting a good night's sleep

5. May Enhance Sleep Quality

Getting a good night’s sleep is essential for overall health and well-being. However, many individuals struggle with sleep disturbances as they age, leading to daytime fatigue, irritability, and a reduced quality of life.

Sermorelin therapy has been associated with improved sleep quality, including better sleep duration and better and more restorative slow-wave sleep (23). However, there are no definitive studies that establish a causative relationship between age-related GH deficiency and sleep problems, and one study showed that GHRH supplementation impaired deep sleep (6).

Researchers at the University of Washington are currently testing the impact of GHRH on age-related sleep disorders in older women who are taking estrogen replacement therapies and men. This study is expected to help researchers better understand the link between GH and restorative sleep. 

6. Healthier Skin and Hair

Since GH affects collagen production and cell growth in skin and hair, it seems to follow that sermorelin, by increasing GH release and production, would improve skin and hair quality.

Collagen is a protein that holds water and provides support for the skin. As collagen production decreases with age, skin becomes less elastic, leading to wrinkles and skin sagging.

Growth hormones are also essential to healing the skin. GH increases skin cell size, growth, and tissue differentiation. Having optimal levels of GH can help boost collagen production, skin density, skin thickness, and skin strength.

Sermorelin may improve skin health by (2, 24):

  • Stimulating the release of natural growth hormones and counteracting the effects of age-related declines in GH
  • Increasing the production of elastin and collagen, key proteins that help maintain skin strength and elasticity
  • Enhancing IGF-1 production, which is critical for skin repair and regeneration

7. Strengthened Immune System

A robust immune system is crucial for maintaining good health and defending against infections and diseases. Growth hormone plays a significant role in immune function, and deficiencies in growth hormone have been associated with immune system dysfunction.

Sermorelin therapy has been shown to enhance immune system function by increasing the production of immune cells and improving the immune response. Researchers found no sex difference in immune response to GHRH analogs, such as sermorelin, and no adverse effects (24).

Sermorelin also regulates the immune system. However, the majority of studies exploring the relationship between GH and the immune system are animal studies. More human studies are needed (2).

Sermorelin has been researched as an effective treatment for glioma, a brain tumor. Researchers found Sermorelin influences the cell cycle and cell division (25). This is important because one concern about increasing HGH is that it may increase cell division and awaken latent cancers (7).

8. Enhanced Libido and Sexual Function

In one study, men taking a GHRH, such as sermorelin, reported a significant increase in their general well-being and libido. The improved libido was not related to changes in serum androgens. Women in the study did not report this improvement in mood and libido (24).

A setting for two with healthy foods

What Factors Impact GH Levels?

To reduce the impact of low GH production with aging, consider lifestyle factors as well. Factors that increase growth hormone release include (26, 27):

  • Fasting
  • Exercise
  • Sleep
  • Stress
  • Low blood glucose
  • Reduced free fatty acids
  • Sex hormones
  • High-protein meals
  • Medications

Consuming nutritious whole-food diets rich in protein and low in processed foods and simple sugars can also improve GH release. Meal timing may also be important. Researchers are evaluating whether intermittent fasting may impact GH release. 

In addition to your diet, monitor your sleep habits and ability to manage stress. Improvements in these two areas can improve your overall health. 

Factors that reduce growth hormone release include (26, 27):

  • Overeating
  • Obesity
  • Aging
  • Increased IGF-1

Obesity and overweight adversely impact your health in many ways. Having obesity can decrease GH production and release. 

Researchers looked at 130 healthy adults from five different age groups with a range of body mass indices (BMI). They found that total and pulsatile 24-hour GH secretion went down as age and BMI went up. However, the single biggest factor affecting GH release with age was BMI. The impact of BMI on GH levels was almost 3.5-fold higher than the impact of age (27).

Women secrete more GH before age 50 but not after age 50. IGF-1 levels decrease with age. Sermorelin effects may be different in men and women.

Factors that affect IGF-1 production and therefore can create GH resistance include:

  • Oral estrogen therapy
  • Fasting
  • Malnutrition
Hormone/FactorEffect on Growth Hormone Release
Growth hormone-releasing hormoneIncreases
Stress, amino acids, and low blood sugarIncreases
Free fatty acidsDecreases
Insulin-like growth factor 1Decreases

What are the potential side effects of Sermorelin?

The most common side effects associated with sermorelin use are injection-site reactions. These include:

  • Skin irritation
  • Itchiness
  • Skin sensitivity
  • Swelling
  • Pain
  • Redness

Other potential side effects associated with sermorelin use include:

  • Difficulty swallowing
  • Facial flushing
  • Dizziness
  • Headache
  • Rash
  • Nausea
  • Sleepiness
  • Taste changes
  • Hyperactivity

Medications that may interact with Sermorelin include (28):

  • Aspirin, indomethacin, and other cyclooxygenase inhibitors
  • Steroids, glucocorticoids
  • Insulin
  • Propylthiouracil and other thyroid medications
  • Atropine and other muscarinic antagonists
  • Levodopa, clonidine, and other somatostatin-containing drugs

Like all medications, people who meet these criteria should not use Sermorelin (28):

  • People who are allergic to sermorelin
  • People with hypothyroidism (low thyroid hormone)
  • People who are pregnant or planning to become pregnant
  • Women who are breastfeeding
  • People with a head or brain injury or a disease that affects the brain or spinal cord, such as epilepsy
Image of an empty vial

How do you administer Sermorelin?

If you have any questions about how to administer sermorelin, talk to your healthcare provider or pharmacist.

Sermorelin is typically shipped at room temperature and stored in the refrigerator after the peptide is mixed with sterile water.

Sermorelin is injected into the fatty tissue just under the skin (subcutaneous injection).

To follow the normal circadian rhythm for GH, sermorelin is typically injected at night before going to sleep and at least two hours after eating. Staying well-hydrated is also strongly recommended.

Foods with a high glycemic index cause spikes in insulin, which can reduce GH production. GH mediates the release of IGF-1 in the liver. IGF-1 and insulin released after a meal may have competing effects.

The typical steps for administering a subcutaneous injection include the following:

  1. Gather your supplies: You will need the sermorelin vial, a syringe, two alcohol prep pads, and an adhesive bandage.
  2. Prepare the medication: Let Sermorelin come to room temperature, wipe the top of the vial with an alcohol prep pad, and let it dry.
  3. Draw up the dose: Open a fresh syringe and needle, and note the unit numbers along the shaft of the syringe. Uncap the needle and pull the plunger to fill the syringe with air to just past your prescribed dose. Insert the needle into the Sermorelin vial. Inject the air into the vial and draw up the sermorelin to your medication dose.
  4. Choose your injection site: Subcutaneous injections can be given into the lower abdomen, front of the thigh, or the back of your upper arm. The lower abdomen is the most common. Alternate your injection sites and avoid any areas that are bruised, red, scarred, or covered by a skin rash.
  5. Inject your Sermorelin. Wipe your injection site with an alcohol prep pad. Allow the skin to dry, and pinch it and the underlying fat with your non-dominant hand. Push the needle into the fat underlying the skin using a firm, smooth motion. Slowly push the plunger to fully inject your sermorelin.
  6. Finish up: Remove the syringe and apply pressure to the injection site with a cotton ball or an adhesive bandage. Place your needle and syringe in a sharps container, and return your sermorelin to the refrigerator.

If your sermorelin contains particles, is discolored, or is past its expiration date, do not use it. If the sermorelin medication vial is cracked or damaged in any way, do not use it.

Sermorelin Anti-Aging Peptide: Reviews and Testimonials

When evaluating sermorelin and its potential benefits to treat age-related GH deficiency, it is important to hear from people who have already used sermorelin and learn from their experience.

Reviews from Invigor Medical patients:

  • “As a 56-year-old guy, I just don’t have the same amount of energy that I used to. My youngest is only 11, and I was looking for a way to still keep up and be the ‘active Dad.’ I tried a bunch of supplements from [nutrition store], and they didn’t seem to do anything for me. Sermorelin was exactly what I was looking for and worth every penny. I feel like I’m 25 again, and even after a long day of work, I have plenty of energy to play catch in the yard, take care of the house and yard, and still get intimate with my wife, too!” Richard H., Boise, ID
  • “I’m very concerned about osteoporosis as I’ve been getting older. The medications my doctor prescribed gave me horrible side effects, and I couldn’t keep taking them. I eat well, exercise, and take a calcium supplement, but was looking for something more. Sermorelin has improved my DEXA score significantly, and I’ve noticed a lot more strength and flexibility in my body.” Samantha Toscano, Durham, NC
  • “On the backside of 40, I feel my metabolism slowing. It’s harder to maintain my weight or lose those holiday pounds that you always put on. At the same time, my body fat percentage is going way up, even though I work out at the gym almost every work day. I needed help, and Sermorelin was that help. Zero side effects—nothing but results.” Greg Lauter, Philadelphia, PA
  • “Since starting Sermorelin around 9 months ago, I’ve noticed a major change in my skin. Before, I had lots of fine lines and wrinkles, and my skin was thinning—taking on that classic crepe-like texture that’s a sure sign of aging. Now, my skin is much fuller, has thickened and plumped back up, and many of the wrinkles and lines have all but disappeared. Two of my friends who hadn’t seen me in a year actually thought I had a facelift, but no, it was Sermorelin. Plus, my energy levels are way up, and I’m in better shape physically than I’ve been in years.” Jen J., Riverside, CA
  • “I was skeptical—how many products claim to be a fountain of youth only to fall flat? But Sermorelin really does boost energy levels, speed up your metabolism, improve muscle mass and body fat percentage, and everything else it claims. It took a few months, but wow—the results are astounding! I’m even sleeping better than I have been in years.” Tim Donegan, Denver, CO
  • “I struggled for years to try to lose weight and get in shape. It seemed to get harder and harder the older I got. I finally committed to the process, changed my diet, and increased my exercise. I still wasn’t seeing the kind of weight loss I wanted—mostly because my metabolism was so damn slow and I ran out of energy for workouts so fast. My nutritionist suggested a peptide, Sermorelin. I figured it was worth a try. Now, 14 months later, I’ve lost 52 pounds, 7 inches off my waistline, and can work out for as long as I want—not pack it in after 15 minutes. It was the extra help I needed. I’m 47 and am at a lower weight now than when I graduated from Purdue in ’94.” Mike Miller, Indianapolis, IN

Besides Sermorelin reviews by Invigor Medical patients, here are other online reviews from Reddit r/Sermorelin.

  • Female user: “It helps my energy level, reduces brain fog, and reduces muscle soreness after strenuous activity to almost zero. It’s amazing. I can tell when I miss a dose, and I can tell when I’ve taken a dose that is past the BUD (beyond use date).”
  • Healthcare user: “Only starting Month #2, so results are still pending. Subjectively, I feel I do sleep more soundly, and muscles feel more firm/toned (slightly).”
  • Unidentified user: “I’ve been taking it every night for 10 weeks solid and, as yet, haven’t seen much difference! I work out 4-5 times a week, but my sleeping habits are really bad—as in, I don’t get enough sleep, which could be the reason for the lack of results. I’m going to keep taking it for another two months and see what happens.”
Sermorelin Infographic

Sermorelin Availability and Cost

Sermorelin is available at Invigor Medical, starting at $14.25 per dose. The 8-mg dose is $285 for a 4-week subscription, and the 15-mg dose is $345 for a 4-week subscription.

According to HGH, HGH injections cost between $750 and $2,000 per month. Sermorelin injections cost between $400 and $750 per month.

According to the HRT Clinic, the cost of Sermorelin injections ranges from $8 to $20 per injection, which is $200 to $400 per month.

Is Sermorelin Therapy Right for You?

Sermorelin therapy offers a range of potential benefits for individuals looking to combat the effects of aging and improve their overall well-being. However, it is essential to consult with a qualified healthcare professional before embarking on peptide therapy. A thorough evaluation of your medical history, current health status, and specific goals will help you determine if sermorelin therapy is suitable for you.

It is also crucial to consider the potential risks and side effects associated with sermorelin therapy. While generally well-tolerated, some individuals may experience temporary injection site reactions, such as redness, swelling, or pain. Allergic reactions are rare but should be monitored. As with any medical treatment, individual responses may vary, and close supervision by a healthcare professional is necessary to ensure optimal results and minimize potential risks.

When buying peptides, such as sermorelin, look for a website that requires you to consult with a medical professional to obtain a prescription if they feel the medication is appropriate. To buy sermorelin, you must have a prescription from a licensed healthcare provider.

Check whether your online wellness clinic has partnered with licensed and reputable U.S.-based compounding pharmacies. If you have any questions about sermorelin, Invigor Medical, and the compounding pharmacies Invigor partners with, talk with an Invigor Medical treatment specialist.

Frequently Asked Questions

Is Sermorelin a steroid?

No, sermorelin is not an anabolic-androgenic steroid. It is a synthetic version of growth hormone-releasing hormone, which is a peptide that stimulates the release of natural growth hormone.

Is Sermorelin legal?

Sermorelin is no longer FDA-approved, but this was because its manufacturer discontinued production because of supply issues (28), not because of any safety or effectiveness concerns. Sermorelin is entirely legal in the U.S., as long as a licensed healthcare provider prescribes it.

It is important to note that sermorelin and other synthetic versions of growth hormone-releasing hormone are banned by the World Anti-Doping Agency. This is because sermorelin has the potential to give its users a competitive advantage.

Does sermorelin boost testosterone levels?

No, sermorelin does not significantly boost testosterone levels. But in one study, sermorelin raised levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which suggests it may help the body make more testosterone naturally (6).

Does sermorelin help build muscle?

Yes, since sermorelin is a growth hormone-releasing hormone analog, it has the same effects on muscle as growth hormone. There is not a lot of research on aermorelin. However, the research currently available indicates that sermorelin increases muscle mass and decreases fat mass.

Is Sermorelin safe?

In one study, GHRH analogs, such as sermorelin, were administered for four months to test their effects on improving the symptoms of aging in older adults. Researchers concluded sermorelin was a safe and effective GHRH analog. The study participants did not experience any adverse effects. The only significant side effect noted was a transient increase in blood lipid levels (24).

Sermorelin is no longer FDA-approved, but this is due to a manufacturing decision, not safety and effectiveness concerns.

How long does it take for Sermorelin to work?

Sermorelin reaches a peak level within about 5 to 20 minutes after you inject it and may remain elevated for about two hours. Growth hormone rises within about 20 minutes after injecting sermorelin.

Studies suggest that regular use for three to six months is necessary to see sermorelin’s full effect.

Do I need a prescription for Sermorelin?

Yes, sermorelin is only available by prescription. A licensed healthcare provider can prescribe sermorelin to treat age-related GH deficiency.

Can you drink alcohol and take Sermorelin?

According to, there should not be an interaction between alcohol and sermorelin use. However, the sugar in alcohol stimulates insulin release. So, drinking alcohol within two hours of taking sermorelin may make sermorelin less effective.

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