NAD+

NAD+ is a cofactor that is an essential part of the process that transfers energy from foods to cells in the body, where it can be used for growth and repair. NAD+ levels gradually decline throughout life.

Patients can purchase NAD+ injections or spray with an included prescription consultation with a doctor.

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Can I Buy NAD+?

Approved patients can buy NAD+ with the included prescription consultation. After consulting with the doctor via an online Telewellness visit and being approved, the pharmacy will send the medication directly to your door.

Do we offer NAD+ as part of a treatment plan?

Yes

Improves Energy	Boost energy, enhance mood, and increase productivity
Reduces Cravings	Effectively manage satiety and reduce cravings
Protect Cells	Protect your body, brain cells, and DNA from oxidative stress

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How Does NAD+ Work?

NAD+ Provides Cells With Energy

NAD+ is an essential component of the metabolic process in every cell in the body. It is a coenzyme that is mostly involved in anabolic processes, building complex proteins and fats. Besides its use in energy metabolism, it is a cofactor for NAD+ dependent enzymes such as sirtuins (SIRTs) and poly (ADP-ribose) polymerases (PARP). Sirtuins and PARPs are both involved in aging and decline over time. PARPs are involved in the DNA repair process.

NAD+ Declines As We Age

As NAD+ is converted to NADPH and back again, some is lost. More is lost with aging, which compromises cellular repair processes. NAD+ levels can be restored through tryptophan or nicotinic acid in the diet. The majority, however, comes from the salvage pathway. NAD+ cannot pass across the cell membrane, but two NAD+ precursors – nicotinamide riboside (NR) and nicotinamide (NAM) – can. Both of these can be obtained from the diet.

NAD+ Injections Replenish NAD Levels in the Body

CD38 is a protein that is involved in age-related NAD decline. Levels of CD38 increase as we age and burn through a lot of NAD+. Increased levels of CD38 and decreasing levels of NAD+ with aging, along with the need for NAD+ for cellular repair, have led researchers to investigate its usage to slow the aging process.

Benefits of NAD+

NAD+ replacement therapy may help mitochondrial function and homeostasis. It is involved in over 500 chemical processes in the body. NAD+ can have important anti-aging benefits. It may help with:

Improved mental clarity
Increased alertness
Better concentration
Enhanced memory function
Stronger athletic performance
Reduced fatigue
Better sleep
More effective DNA repair
Decreased skin damage
Weight loss
Better heart function
Better immune function

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Where Do I Start?

Start by Selecting a Treatment Plan

NAD+ Treatment Plan

Mental Focus, More Energy, Reduced Oxidative Stress

Cellular damage accumulates as NAD+ levels decline. Animal models have shown that replenishing NAD+ can have important anti-aging benefit...

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Drug Details

Indications

What is NAD+ used for?

Off-label treatment for:

Low energy
Mental fog
Low concentration
Chronic fatigue
Poor sleep
Body fat
Immune function

Contraindications

You should avoid NAD+ if you are/have:

There are no known contraindications, except for a known allergy to NAD+
The safety of NAD+ in pregnant or breastfeeding women has not been evaluated. It should not be used by pregnant or breastfeeding women.
If you already have cancer, NAD+ can potentially fuel cancer growth. NAD+ is a molecule used throughout the body, and supplementation may trigger a mix of positive and negative outcomes.

NAD+ Side Effects

What are the side effects of NAD+?

NAD+ appears to be safe and well tolerated. Potential side effects include:

Common NAD+ Side Effects

Headache
Shortness of breath
Constipation
Increased plasma bilirubin
Decreased gamma-glutamyl transferase, lactate dehydrogenase, and aspartate aminotransferase

Rare NAD+ Side Effects

High doses of nicotinamide can cause liver injury.
High doses of niacin as a supplement to increase NAD+ levels can cause headaches, skin flushing, and dizziness. Excessive intake of niacin or nicotinamide may contribute to the development of Parkinson’s disease. In addition, nicotinamide may contribute to the development of diabetes.

NAD+ Dosage Information

NAD+ Dosage & Frequency

Typical NAD+ Dosage & Frequency

0.3mL of 1000mg/mL
Daily

References

Age-associated Changes in Oxidative Stress and NAD+ Metabolism in Human Tissue
https://pubmed.ncbi.nlm.nih.gov/22848760/
Clinical Evidence for Targeting NAD Therapeutically
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558103/
Nicotinamide Adenine Dinucleotide: Summary Report
https://archive.hshsl.umaryland.edu/bitstream/handle/10713/15463/NAD_Final_2021_02.pdf?sequence=4&isAllowed=y
Overview of Nicotinamide Adenine Dinucleotide (NAD+) Injection
https://www.empowerpharmacy.com/drugs/nad-injection
An Open-label, Non-randomized Study of the Pharmacokinetics of the Nutritional Supplement Nicotinamide Riboside (NR) and its Effects on Blood NAD+ Levels in Healthy Volunteers
https://pubmed.ncbi.nlm.nih.gov/29211728/
Pharmacy Compounding Committee Review: Nicotinamide Adenine Dinucleotide (NAD+)
https://www.fda.gov/media/113016/download

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