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Trimix Injection Side Effects: What To Know

Jun 18, 2020
Trimix Injection Side Effects: What To Know

Most men tend to experience some erectile dysfunction during their lifetime.  It becomes more common with age, as well as in men with underlying health conditions (which themselves become more common with age).  However, it’s a myth that erectile dysfunction only happens to older men.  While it is more common, otherwise healthy men can experience some ED, even severe ED, as early as their 20s. 

Many men can improve their erectile function with health and lifestyle changes.  More severe cases of ED may require oral ED medication.  In some cases, even that doesn’t work.  That’s when the powerful medication Trimix is often prescribed. While Trimix injection side effects are uncommon they can still occur and this is what you need to know.

In this article, we’ll take a look at Trimix side effects. We’ll also look at precautions and contraindications, and other risk factors associated with this medication.  This is not meant as a substitute for a consultation with your doctor or prescriber, but merely to help inform patients of the potential risks associated with Trimix use.  Every individual is unique, and medical history, underlying health conditions, and current or past medications – along with physiology, genetics, and other factors – all play a role in determining why some people experience side effects while others don’t.  This article serves simply as an informative overview of Trimix injection side effects, their frequency and severity, and so on.  So, let’s get started!

Background On Trimix

For those unfamiliar with Trimix, we encourage you to read some of the other articles we’ve written about the medication. They go into far more depth about Trimix than we will include here.  However, as a brief reminder or primer, Trimix is an injectable erectile dysfunction medication.  It contains three separate medications—phentolamine, papaverine, and alprostadil — designed to improve erectile function on their own. They work even better together.  Each works in a slightly different way, but all have the primary function of increasing muscle relaxation and blood flow. Those are the two key aspects of the body’s requirements to attain and maintain an erection.

Trimix Injections
Mentioned Product

Trimix Injections

Trimix is used as a second-line treatment when oral ED medications don’t work. Patients who purchase Trimix injections have an 80-95% success rate.

Learn About Trimix

Trimix Intended Use And Administration

Trimix is meant to be injected locally into the penis, about 20 minutes before sexual activity.  It is considered as a treatment only after trying and not receiving satisfactory results from oral ED medications. Trimix is only available with a prescription.  When properly used, an erection typically begins within 5 to 20 minutes of administration and lasts between one to two hours in most men.  In some men, it may go away after orgasm and ejaculation, in others, it may persist.

In most studies, as well as decades of real-world use, Trimix was found to be extremely effective.  Men who did not receive satisfactory results in treating their ED with oral medications like Viagra or Cialis are almost always successful when they purchase Trimix shots.  Between 80 and 95% of men (the exact rate varies from study to study) report erections satisfactory for penetrative sex with Trimix.

Trimix Injection Side Effects

Precautions And Contraindications

As a prescription medication, and one that is delivered via injection, there are some precautions and contraindications that need to be considered prior to buying Trimix injections online.  Trimix injection side effects are also important to consider, as we’ll discuss in more detail in the rest of this guide. 


From a precautions standpoint, users need to fully understand and comply with dosing instructions provided by the prescriber.  Too large an increase in dose at once, too high a dose, or too frequent use can all increase the likelihood of severe Trimix injection side effects, some of which may require emergency medical intervention.  At the same time, because the drug is injection-based, proper injection procedures are required. This includes safe needle handling and disposal and proper medication storage.  This should be covered in the safety information provided with Trimix prescriptions, as well as discussed with your prescriber in advance.

Perhaps most importantly, from a precaution standpoint, Trimix should not be injected anywhere but the penis. The exact locations for acceptable injection are indicated in the prescribing literature.  Injection into other muscles, the bloodstream, or elsewhere in the body may result in serious and life-threatening side effects, as it is not intended for use in these locations. 


In terms of contraindications, you should not buy Trimix if your doctor has determined that your heart is not healthy enough for sexual activity.  You should also not use Trimix if you are currently taking oral ED medications on a regular basis.  Trimix doesn’t act systemically. However, it’s always important to discuss all your current and previous medications, including herbal and over-the-counter medications, with your doctor prior to starting Trimix for the first time.

This is not a comprehensive list of all contraindications – see the prescribing literature or discuss with your doctor to learn more.

Trimix Injection Side Effects: What To Know

Trimix Injection Side Effects – Common

When it comes to Trimix injection side effects, the good news is that there aren’t that many. On top of that, they tend to be mild when they do occur.  This is largely the result of the injection acting locally rather than systemically as with oral medication.  The most common Trimix injection side effects include:

  • Stinging, pain, or soreness at the injection site, which usually is temporary and goes away after a few minutes
  • Slight bleeding at the injection site immediately after injection
  • Bruising that can occur at the injection site (though proper injection technique will minimize or prevent this from happening)
  • Poor hygiene or failure to follow proper injection procedures may increase the risk of developing an infection

Trimix Injection Side Effects – Less Common

Less common Trimix injection side effects range from mild to severe, though their incidence tends to be low.  However, again we remind patients that everyone is unique. So, it’s especially important to monitor for side effects the first few times you use Trimix, and report them to your doctor or healthcare provider if they do occur.  The less common side effects include:

  • Diarrhea, nausea, stomach cramps, or vomiting
  • Allergic reaction (hives, swelling, itching, etc.)
  • A sudden drop in blood pressure
  • Increased heart rate
  • Abnormal heart rhythm
  • Fibrosis or scarring at the injection site
Trimix Injection Side Effects: What To Know

Trimix Injection Side Effects – Too High A Dose Or Overuse

The most serious Trimix injection side effects tend to result from too high a dose or overuse – injecting Trimix more frequently than the prescribing instructions state.  This can lead to a prolonged erection lasting 4 hours or more, which does not go away on its own.  This condition, known as priapism, is considered a medical emergency.  It requires emergency medical care to counteract the erection, or serious and permanent damage can be done to the penis.

In rare cases, this may be a reaction to the Trimix, even absent a high dose or too frequent use.  The chance of this side effect increases as dosage increases, and especially if the contraindication regarding not using oral ED medications is ignored.  For these reasons, doctors and prescribers tend to start patients on a low dose, and then increase it gradually based on feedback, until satisfactory results are achieved.  Patients should always aim to use the lowest effective dose, as erection quality does not tend to increase at higher dosages, but the potential for Trimix injection side effects does. 


When you’re ready to buy Trimix, it’s important to be informed about the potential side effects of the injections, which range from mild discomfort at the injection site to more serious issues like prolonged erections. Understanding these risks and how to manage them is crucial, and Invigor Medical provides detailed guidance to ensure safe usage. For those considering Trimix injections as a treatment for ED, visit Invigor Medical to learn more about the precautions, effectiveness, and to make your purchase with confidence.

Frequently Asked Questions

How Much Trimix Should You Take?

Your doctor or prescriber will discuss the proper dosage with you prior to beginning Trimix.  There is no standard dosage, but rather a typical dosage range.  Most prescribers will start new patients out with 5 to 20 units (5 to 20 mcg) per dose.  This will then be increased by 5 units at a time in each subsequent administration, up to around 50 units as the typical upper limit.  You should always follow the dosage and increment plan and guidelines provided by your prescriber and aim to use the lowest effective dose to achieve your desired results.  This will help to minimize the potential for Trimix injection side effects.

Why Does Trimix Require A Prescription?

Trimix is a very powerful medication.  If it is misused, such as if too much is injected or it is injected in the wrong place, there can be significant negative consequences.  As such, a prescription is required.  This helps ensure proper administration, dosing, and precautions are observed to minimize Trimix injection side effects and negative outcomes.  It is also not meant as a first-line treatment for ED, but for those men who have tried unsuccessfully to achieve satisfactory results with oral ED medications.  However, it’s easy to buy Trimix through Invigor Medical and have the Trimix shipped right to your home.

Is Trimix Effective?

Several decades of real-world experience, along with dozens of studies, have shown that Trimix can be extremely effective at restoring satisfactory erectile function in most men.  Some studies have found that all participants reported satisfactory results, despite mixed or no results from oral ED medications.  Others have found lower rates of reported satisfaction, but still significantly more than with oral ED medications.  Most studies agree the range of efficacy is around 80 to 95% satisfied study participants, and the same holds true anecdotally in clinical practice. 

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.


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