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Trimix Cost: Are They Expensive?

Jun 21, 2020
Trimix Cost: Are They Expensive?

One of the most frequently asked questions on the Internet today regarding the erectile dysfunction medication Trimix is, “How much does Trimix cost?”  It’s a reasonable question – after all, most healthcare-related things today seem to cost an (almost literal) arm and a leg.  While it’s not necessarily easy or straightforward to provide a simple answer to that question that is true for everyone, we’ll do our best to explain the basics of Trimix injection costs, and how to buy trimix online in this article.

The good news to start with is that Trimix injections cost less than you might think and are largely cost-competitive with oral ED medications.  As Trimix is designed for men who have not had success with oral ED medications and is far more powerful and effective, the fact that it is similar in cost and not several orders of magnitude more expensive is a relief to many men considering it.  But there’s more to it than that, so let’s dig a bit deeper.

Quick Overview Of Trimix

First, it’s useful to recap what exactly Trimix is and how it works.  While we’ve covered this topic in much more depth in other articles on our site, a brief refresher can help.  Trimix is an injection-based erectile dysfunction treatment.  It is made out of three separate medications, compounded together – phentolamine, papaverine, and alprostadil.  These medications are designed to help increase blood flow or encourage muscle relaxation, the two mechanisms necessary for a man to achieve and maintain an erection. 

The medication is injected into the penis approximately 20 to 30 minutes before sexual activity and provides an erection that typically lasts one to two hours.  Over several decades of use and numerous studies, it has been found that upwards of 95% of men treated, despite having no luck with oral ED medications, were able to achieve satisfactory results with Trimix.

Because Trimix needs to be injected, and because it is a fairly powerful medication, it is only available with a prescription in the United States and many other jurisdictions.  This means that individuals can source it by obtaining a prescription from their doctor and visiting a local compounding pharmacy that carries it (which can often be a challenge).

Trimix Cost: Are They Expensive?

Why There’s No Single Answer To “How Much Does Trimix Cost?”

It may seem like there should be a simple, single answer to, “How much do Trimix injections cost?”  Of course, there is variation depending on where you buy it, like any medication or really anything you purchase.  But there are also other factors that can drastically alter the price per injection on a net basis.  The most influential of these factors is the dose of Trimix that is needed for a particular patient.


Trimix is typically sold in vials of a set volume – most often 5 mL or 10 mL.  Patients use a fraction of this each time they take a Trimix dose, based on the dosing schedule prescribed by their doctor.  Since everyone responds differently, most practitioners start new patients out on a relatively low dose, allowing for gradual increases until the desired results are achieved.  It’s always best to use the lowest effective dose, as the risk of side effects increases at higher doses. 

Therefore, the final, stable dose that Patient A might be using can be quite different from Patient B.  Two patients using an identical volume or vial of Trimix may get a vastly different number of doses out of it.  Since that makes up the denominator in any equation relating to cost per dose, there’s obviously a great deal of individual variability in answering, “How much do Trimix injections cost?”

Syringe and Vials of Medication Trimix cost

Other Factors

Other factors can also play a role in the final cost of Trimix injections.  The medication has a limited shelf life in the refrigerator after it is first opened (normally stored in the freezer until opening and then stored in the refrigerator for subsequent dosing).  It lasts only about 3 months in the refrigerator.  So, if only used very infrequently, patients can end up with wastage of a certain amount of the medication.  The net effect would be an increase in each injection’s effective cost since some portion of the total vial would be wasted.

About Insurance Coverage For Trimix

One topic that often comes up in relation to discussing, “How much do Trimix injections cost?” is insurance.  Since Trimix is a compounded medication, it is not covered within the vast majority of insurance programs in the United States.  That means that, even with insurance, the cost paid for Trimix tends to fall mostly on the patient, and tends to be about the same as those who don’t have insurance.  On the upside, that means that the price is maintained at a relatively accessible level – not thousands of dollars per dose like some more exotic drugs.

Whether you fill a prescription through your doctor at your local pharmacy, you will be paying about the same for Trimix.  Every pharmacy has its own pricing structure to cover overhead and other expenses, of course, but generally speaking, prices will be within the same range as one another.  When insurance does cover Trimix, it usually only does so for clinical injections (e.g., administered by a nurse or doctor in their office or another facility), which is not the ideal use case for Trimix, nor suitable for the vast majority of patients looking to use it for sexual activity.

Image of an empty vial

So, How Much Does Trimix Cost?

OK, you’ve waited long enough!  Below, we’ve put together a few examples to answer the question about how much do Trimix injections cost.  Please note that for legal reasons, we cannot list the names of our competitors, and have obscured them with “Company X” or similar generic terms.  However, rest assured that their pricing (and ours) was accurate as of the day this article was written.  However, that may change in the future, so it’s always best to check the latest pricing to buy trimix shots if you are doing any of your own calculations.

Some Notes

Note also that we’ve included two price points to account for the different dosages that a patient may take.  One is the typical minimum dose of between 5 and 20 units, and the other is the typical maximum dose of 50 units.  Naturally, individual doses may differ significantly between these two ends of the spectrum. The answer to, “How much do Trimix injections cost?” would then need to be recalculated accordingly for that individual.

Trimix Injections
Mentioned Product

Trimix Injections

Trimix Injections are used as a second-line treatment when oral ED medications don’t work.

Learn About Trimix Injections

Further, we’ve normalized the unit pricing to ensure comparison of comparable formulations (as a compounded medication, with 3 active ingredients, they can be combined in many different ratios ).  Naturally, a formulation with more active ingredients will cost more than one with smaller quantities of those same ingredients.  This ensures that all normalized prices below reflect the same formulation available from Invigor Medical, with the same potency and ratios of ingredients.

Additionally, you have to take into account shipping costs (some companies charge this separately), as well as appointment/consultation costs (again, some companies charge this separately).  Where shipping costs are variable based on geographic location, we have used an average of three measurements (New York City, Los Angeles, and Topeka, Kansas).

Price Comparison Table

 Invigor MedicalCompany XCompany YCompany Z
Vial Size5 mL5 mL5 mL5 mL
Total Cost$272.75$397.01$368.42$318.84
Cost Per Dose AtInvigor MedicalCompany XCompany YCompany Z
20 mcg/Dose$10.91$15.64$14.74$12.75
50 mcg/Dose$27.28$39.70$36.84$31.89


When looking to buy Trimix, cost is an important factor to consider. Invigor Medical provides Trimix injections that are competitively priced compared to oral ED medications. Being more effective for those who have not found success with oral options, Trimix comes as a relief for many, balancing affordability and powerful results. For exact pricing and to understand how much your prescription may cost, checking out Invigor Medical’s detailed guide will equip you with the necessary information to make an informed purchase.

Frequently Asked Questions

Why Does Trimix Require A Prescription?

Trimix is a very powerful medication.  It is also not available off-the-shelf from a manufacturer, but rather must be blended in a compounding pharmacy.  For these reasons, it requires a prescription to dispense in the US and most other jurisdictions.

If you find a website where you get Trimix Injections online without requiring a prescription, that is a major red flag, as they are likely operating illegally.  You also don’t know what kind of medication you are getting in those instances – it could be contaminated, impure, or not useful at all – just plain old water.

How Long Does Trimix Last?

Trimix typically starts to work in 5 to 20 minutes, so it is recommended that you take it around 30 minutes before initiating sexual activity.  It starts to work right away, and most men start to see results within about 5 minutes, which typically gets stronger over the next 20 minutes.  Once an erection is achieved, it usually lasts for one to two hours.  It may diminish following orgasm and ejaculation in some patients, and it may not in others.

If an erection lasts 4 hours or longer, you need to seek emergency medical attention (or use the antidote/erection reversing medication that is also available with your order).

Can I Use Trimix If I Am Taking Oral ED Medications?

You must discontinue the use of oral ED medications prior to taking Trimix.  Using them both together will drastically increase your risk for developing a painful, long-lasting erection of 4 hours or more, which is a medical emergency and can cause permanent damage to the penis. 

Only use Trimix as directed, in the dosages prescribed, and at the frequency mentioned in the prescribing information.  Do not use too often or more than prescribed.  Higher dosages increase the risk of side effects.  Observe all other precautions, contraindications, and information provided by your prescriber.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.


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