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Trimix Dosage: How Many Units Of Trimix Should I Take?

Jun 20, 2020
Trimix Dosage: How Many Units Of Trimix Should I Take?

The erectile dysfunction medication Trimix has been shown, time and time again, to be an effective remedy for men who haven’t had success with oral ED treatments.  It is available by prescription only and is a very powerful combination of three proven ED medications – phentolamine, papaverine, and alprostadil. Trimix is delivered via injection.  There is no standard dosage, and it is usually incrementally tailored to the individual via feedback between the patient and the prescriber.  However, the most common question people usually have about Trimix dosage is, “How many units of Trimix should I take?”  In this guide, we will help to answer that question and explore why there is no one-size-fits-all answer.

The Basics Of Trimix For Erectile Dysfunction

First, it’s useful to go over some of the basics of Trimix – what it is, how it functions, and so on.  Trimix is an erectile dysfunction treatment that is designed for local injection into the penis.  Unlike oral ED treatments, where any benefit or action is spread throughout the body and bloodstream, Trimix’s direct local action in the penis means it is often far more effective in generating an erection satisfactory for sex. 

Though the administration method is different, Trimix works following the same general mechanisms of oral ED medications like Viagra and Cialis – specifically, relaxation of blood vessels and improving blood flow.  These are the two primary biological requirements to sustain an erection.  Because it’s generally more effective and powerful (and therefore, somewhat riskier), it is reserved as a secondary treatment for ED. It is only suitable for patients who have had no success with oral ED medications.

Most patients who have taken Trimix, both in studies and in the real world, have seen significant results.  As many as 95% of men reported satisfactory erections for penetrative sex thanks to Trimix, even after treatment with oral ED medications had failed them. 

Trimix Dosage: How Many Units Of Trimix Should I Take?

How Trimix Is Used

Before getting into the details on how many units of Trimix might be prescribed, let’s talk a bit about how patients typically use Trimix.  Patients who are prescribed Trimix are given advice and information on the proper handling and administration of the medication via injection.  An injection is usually in the middle third of the penis shaft, on alternating sides and avoiding all veins, around 20 to 30 minutes before sexual activity.  Proper administration reduces or eliminates any potential side effects or injuries that may otherwise occur to the penis with injection. Always use proper hygiene and safety precautions when performing an injection, especially in such a sensitive area. 

Trimix, once injected, starts to work right away.  That is true, regardless of how many units of Trimix are in a given injection.  Most men start to see an erection resulting in as little as 5 minutes, which typically increases in rigidity over the course of 20 minutes or so.  The resulting erection most often lasts for one to two hours, and may or may not go away after orgasm or ejaculation. 

However, as with all ED treatments, persistent erections can be a problem.  Erections lasting longer than 4 hours are dangerous and considered a medical emergency.  If proper dosage and administration instructions, precautions, and so on are observed, however, the vast majority of people taking Trimix do not experience any such complications.

trimix dosage done right

Understanding Trimix Dosage

Trimix is supplied as a liquid medication in a vial, designed for injection.  In order to successfully administer Trimix, patients must understand liquid dosing amounts for injections.  For this purpose, it’s useful to define a few terms and units, so that there is no confusion as to proper dosing amounts.  Then we can move on to discussing how many units of Trimix are typically prescribed for patients.

Terms And Units

  • mL or milliliters – a measure of liquid volume, equivalent to 1 cubic centimeter (cc).
  • cc or cubic centimeter – a measure of volume, equivalent to 1 milliliter (mL) of liquid.
  • mcg or micrograms – a measure of mass, equivalent to 1/100th of a cubic centimeter (cc) or milliliter (mL)
  • units – in the case of Trimix and other injectable medications, this is a term synonymous with micrograms

So, given the above, the first thing patients should know regarding how many units of Trimix they should take is what a unit is – a microgram.  There are 100 micrograms in a cubic centimeter or milliliter of medication.  A doctor advising you to take, for example, 20 units of Trimix is saying you should be filling up a syringe with 20 mcg, or 1/5 mL of medication. 

Some mixtures of the medication are diluted with saline, to make dosing and measurement easier on a larger scale, though the effective dosage units/amount also scales.  For example, a 10% solution of Trimix for the same effective 20 mcg/20 units dose would come with instructions to administer 200 mcg or 2 ccs/mLs of the diluted medication.

In all cases, whatever the particular mix, strength, and dosage that is recommended for you will be discussed with your doctor/prescriber.  You should be sure to ask them any questions or seek any clarifications to ensure you are only administering the correct dosage, as higher dosages carry an increased risk of side effects – including erections that require medical attention.

Vial and syringe

How Many Units Of Trimix Should You Take?

As discussed above, there is no generic or one-size-fits-all answer to the question of how many units of Trimix any individual should take.  However, there are some typical dosage ranges, best practices, and other details that may be helpful for those new to Trimix and dosing.

Lowest Effective Trimix Dosage

Since Trimix is a powerful medication, and the risk of side effects tends to increase as dosage increases, most prescribers will start patients out on a relatively small dose.  How many units of Trimix this may be can vary, but is generally below 25 (though we do offer some fairly standard and specific guidelines below).  This can then be adjusted upward by small amounts based on patient feedback and experience, up to a certain upper limit, until satisfactory results are seen.  Patients should always use the smallest effective dose, as, after a certain point, there is no benefit to increasing the dosage further, and the risk of side effects will increase significantly.

Discussion With Prescriber

In addition to a host of precautions regarding how frequently to use Trimix, and other medications to avoid while using Trimix (e.g., oral ED medications), most prescribers will discuss an appropriate starting dose, the amount by which patients can increase dosage each time, and an upper limit of how many units of Trimix to take in any single administration.  Most often, this roughly translates into:

  • A starting dose of between 5 and 20 units of Trimix.
  • Increasing subsequent dosages by no more than 5 units at a time.
  • Maximum dosage of 50 units of Trimix at a time.

That does not mean, however, when looking at how many units of Trimix may be useful for a given individual, that dosages higher than 50 units have not been prescribed.  Typically, however, these are special or less common cases requiring subsequent visits or consultations with the prescriber to ensure the patient’s safety. 

correct trimix dosage

Follow The Prescribing Information

The best chance of achieving a positive outcome with Trimix is to follow all of the prescribing information, literature, and instructions provided.  By doing so, and observing the precautions, administration instructions, and dosage guidelines set by your prescriber, you will likely see satisfactory erections suitable for sex, without the painful and potentially dangerous side effects like persistent or painful erections, priapism, or damage to the penis.  That’s why you should never rely on Internet searches or articles like this alone to determine how many units of Trimix are suitable.  Only your prescriber can tell you that safely.

Where To Get Trimix

Since Trimix is only available with a prescription, you can choose to get it by discussing with your primary care or men’s health specialist and seeking a prescription before you buy Trimix. If so, a prescription will be issued and transferred to the associated compounding pharmacy to be filled and sent to your home for you to start using.  Many men find this a more appealing and approachable alternative to embarrassing in-person discussions with their doctors.

Trimix Injections
Mentioned Product

Trimix Injections

Trimix Injections are used as a second-line treatment when oral ED medications don’t work.

Learn About Trimix Injections

Concluding Thoughts

If you are considering buying Trimix, and deciding if it might be right for you, then talk to your doctor.  Trimix has been shown to be very successful in treating ED, especially in men, for whom oral medications have not been effective. 

Sourcing your Trimix through a licensed and reputable pharmacy, with a prescription, is the only way to go. You do not want to seek out counterfeit or contaminated medication, especially when it comes to injecting something into your penis.

Frequently Asked Questions

How Long Does A Trimix Injection Last?

Trimix should produce an erection lasting around one to two hours, usually within 20 to 30 minutes of administration at most.  After this time, it should lose its efficacy, and any erection should go away on its own.  For some men, erections during the effective time period go away following orgasm and ejaculation, whereas for others, they do not. 

Erections that don’t, however, and last 4 hours or longer are considered dangerous, and a medical emergency, and you should seek emergency medical care to avoid potentially permanent damage to your penis.  The risk of this outcome increases with higher dosages, which is another reason to be sure to follow your prescriber’s instructions with regard to how many units of Trimix to take.

How Effective Is Trimix For Treating Erectile Dysfunction?

Trimix is considered very effective for treating ED.  In studies of men who did not see satisfactory treatment via oral ED medications, Trimix injections resulted in between 80 and 95% satisfaction rates, depending on the study.  Individually, the medications that make up Trimix all produced some positive results, but their combined use success rate outweighs their individual success rates.  It is important to note, however, that Trimix does not cure any underlying causes of ED, but can be an effective treatment to produce erections satisfactory for penetrative sexual intercourse. 

Is Trimix Safe To Use?

Trimix is a prescription medication, and naturally has risks associated with it.  However, if proper injection technique is used, precautions are followed, and all health or medication history disclosed to the prescriber, the risk of side effects is fairly low.  As mentioned above, side effects tend to increase with higher dosages, so it is important only to take the number of units of Trimix you have been prescribed, not more.  You should not take Trimix more frequently than specified or inject it anywhere other than in the appropriate part of the penis.
The most common side effects are injection site pain, small amounts of bleeding immediately following administration, and some initial discomfort.  Poor hygiene may increase the risk of developing infections, and overuse – such as taking too high a dosage – increases the risk of priapism/erections requiring emergency medical care. 

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.


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