Erectile Dysfunction
Updated: Nov 10, 2021
How and Where to Buy Trimix
Published: Mar 5, 2020

The Basics of Trimix for Erectile Dysfunction

Trimix is an erectile dysfunction treatment that is designed for local injection into the penis.  Unlike oral ED medications, which work systemically, Trimix’s local action means it is much more effective for the intended purpose of causing and maintaining an erection satisfactory for sexual intercourse.  It is similar to oral ED treatments, in that it works on similar principles – relaxation of blood vessels and improving blood flow – the two essentials for the mechanism of erection to work.  Because it’s an injection-based medication, however, it’s not a first-line treatment. It is only recommended for men who have had little or no success in achieving an erection and reversing their erectile dysfunction with an oral ED medication or men with medical conditions that preclude the use of oral ED medications.  That’s an important fact to keep in mind and a theme that we’ll get back to as we discuss how Trimix is used and where to buy it later in this guide. 

As the name implies, Trimix is made up of three specific medications mixed into one compound.  All three work in somewhat different ways, but towards the same end goal of producing and maintaining an erection for sexual activity.  Without getting into the technical specifics, these medications are papaverine, alprostadil, and phentolamine.  While they work individually, studies have found them to be especially effective in combination and with fewer side effects.  As many as 95% of men who participated in erectile dysfunction studies with oral ED pills, then subsequently Trimix injections when oral ED pills failed, saw effective results from Trimix (Seyam et al., 2005).

Use of Trimix

Injection technique

In order to use Trimix, a doctor or healthcare provider needs to instruct patients on the proper way to administer the injection.  Typically, the injection site is in the middle third of the shaft of the penis at the 10 o’clock or 2 o’clock position avoiding any veins, 20 to 30 minutes before sexual activity.  Proper antiseptic measures to guard against infection or contamination of the medication are required.  Administering the injection in the right spot is essential and should be reviewed with your prescriber prior to use.  Always observe proper syringe safety and hygiene, and don’t re-use syringes, either.  Follow all storage and handling precautions provided with the Trimix medication leaflets and consistent with your prescriber’s instructions.

Trimix dosage

The amount of Trimix to use will vary by individual.  Typically, doctors will start you on the lowest effective dose and may tweak the dosage upward several times as needed in order to establish what works best for you.  You should not make these adjustments on your own, but in consultation with your healthcare provider/prescriber, to ensure you do not use too much.  There are numerous other precautions on the frequency of use, amount of injection, and so on that should be followed, though are largely outside the scope of this particular guide on how and where to buy Trimix. 

Importantly, once you inject Trimix, it starts to work right away, and most men see results (e.g., an erection) within 5 to 20 minutes.  This erection usually lasts for one to two hours, and may or may not go away with orgasm or ejaculation.  Erections lasting longer than 4 hours, however, are dangerous as they may damage the structure of the penis. Prolonged erections are called priapism and are considered a medical emergency.  If Trimix is working in the right dosage, however, most individuals do not experience that issue.  The incidence of priapism with Trimax ranges from 0% to 3.7% of users (Seyam et al., 2005).

Why Trimix Requires a Prescription

Trimix is only available by prescription, in consultation with a doctor or other healthcare provider.  This is because of its nature as a potent injectable medication, the misuse of which would cause serious side effects.  It is not meant to be injected into the circulatory system, or it may have serious – possibly fatal – side effects.  Likewise, abuse or over-use can lead to the aforementioned serious medical situation, known as priapism, where an erection lasts longer than 4 hours and may permanently damage your penis. 

It is essential that you understand the risks and benefits of using Trimix and know how to use the medication safely. Add to that the likely need to adjust or modify dosage, and it’s clear this is not something you can simply buy over-the-counter safely. 

How to Buy Trimix

Before you consider how and where to buy Trimix, the first step is to try an oral erectile dysfunction medication – or several.  Each works in a slightly different way than the other, with different pros and cons.  Trimix is only suitable for men who have tried oral ED medications with no or unsatisfactory results.  If you have exhausted those options, however, then Trimix may be a good choice.

In terms of how to buy Trimix, the first step is to schedule an appointment or consultation with a doctor or licensed prescriber — either your regular primary care physician or general practitioner, male health specialist, etc., OR you can choose a discreet online consultation via a telemedicine provider, such as Invigor Medical.  For many men, this is the preferred route – it’s a lot easier to talk comfortably about your ED concerns and issues remotely with a doctor you don’t see for all your other health concerns, who specializes in men’s health issues like ED.  There are numerous other benefits, too, including convenience, speed, accessibility, and cost.  We’ll address several of these advantages in our discussion of where to buy Trimix below. 

Where to Buy Trimix

There are three primary sources or routes you can take when considering where to buy Trimix.  The second of the three should generally be avoided – at least if you want to know where to buy Trimix safely and securely – and each of the other two options has different pros and cons to consider.  While we’re certainly encouraging you to choose Invigor Medical, we’ve attempted to provide an unbiased, factual comparison of these three choices of where to buy Trimix. 

Primary Care/General Practitioner and Local Pharmacy

The traditional route is to buy Trimix through your primary care physician, general practitioner, and/or a specialist like a urologist, who will provide a prescription to be filled at your local pharmacy of choice.  There is no doubt that this can be an appealing option since your existing doctor(s) should be aware of your health conditions, medications, and medical history.  However, it can be uncomfortable for many men to discuss erectile dysfunction, to begin with, let alone talk about ED injections. 

There are also several drawbacks, including long wait times to secure an appointment, lengthy waits in the practitioner’s office, and the associated costs – co-pays and so on – that your doctor’s visit may require.  After that, you need to take a separate trip to a pharmacy to get your prescription filled, and likely return later to the pharmacy to pick it up.  All of those tasks take time and effort and can cost a significant amount of money, even with good insurance. 

Online Pharmacies without a Prescription

Naturally, men looking for less hassle, faster service, and fewer awkward questions – and perhaps a lower cost – may turn to the Internet to find where to buy Trimix.  You will undoubtedly find many so-called online pharmacies and other businesses that may advertise Trimix injections available without a prescription.  Prices may be extremely low, too – and you think you’ve struck gold and got one over on the medical system.  But think again!  Any site advertising Trimix as available without a prescription should be a huge red flag – it is not legal to provide it without a prescription in the US.

Pharmacies offering Trimix without a prescription requirement are likely scams.  There’s no guarantee you’ll get any medication, as they may just be looking for your payment information to exploit.  If you do get any medication, it may be diluted, contaminated, or even plain water.  The product’s quality and safety is an open question. Its suitability for use for you is an open question, and the safety and security of your payment and personal information is also likely suspect. 

In short, when you are looking for where to buy Trimix, you should NEVER choose an online pharmacy or business that does not require a doctor’s prescription – your manhood is too important to risk injecting it with who knows what.  Several references provided at the end of this guide describe the risks of purchasing ED medications without a prescription.

Telemedicine Consultation and Associated Online Pharmacy

However, online telemedicine providers and their associated or affiliated online pharmacies combine the best of traditional doctor/patient/pharmacy relationships, with all the benefits of modern technology.  Telemedicine consultations provide a licensed healthcare provider to review your medical history, medications, and health conditions and discuss your particular health issues related to erectile dysfunction.  If you are a suitable candidate, they will prescribe Trimix for you and transmit the prescription to their associated online pharmacy.  The prescription will be filled and shipped to your home in a matter of days. 

This presents numerous compelling advantages that easily underscore why so many patients recommend this option for where to buy Trimix.  It’s fast, easy, and affordable.  It’s easier to talk about your sexual health and erectile dysfunction when there’s some physical and mental distance between you and your doctors – such as the computer screen or telephone – rather than in person.  At the same time, you’re getting the safety and security of a legitimate, licensed professional who can ensure that you’re a good candidate for Trimix use.  You’ll have someone you can count on if you need to adjust the medication levels or have questions or issues about using Trimix.  The convenience of digital appointments, with little to no waiting and the automatic forwarding of the prescription to the associated online pharmacy, saves you time, hassle, and money. 

At the same time, telemedicine providers like Invigor Medical only work with licensed, US-based pharmacies to fill your order.  You can rest assured that you are getting medication of a quality and purity consistent with anything you’d find at your local pharmacy – medication manufactured to the FDA’s requirements.  There are no contaminants, no dilutions, and no scams – just the high-quality medication that your telemedicine doctor has prescribed and you have paid for.  Likewise, as legitimate, licensed US businesses, telemedicine consultants ensure that your personal, medical, and financial information is protected as well, using industry-standard encryption and security for your online transactions.  In short, it’s the best of both worlds – the traditional and the digital – in one safe, convenient, and easy-to-use service. 

Frequently Asked Questions

How long does a Trimix injection last?

Trimix injections typically take between 5 and 20 minutes to start working – it varies by individual.  Once an erection is achieved, it usually lasts for between one to two hours.  It may or may not go away after orgasm and/or ejaculation, and may simply last until the effective time period has elapsed.  If an erection lasts longer than four hours, it is considered a medical emergency, and you should seek immediate medical attention to avoid potentially permanent damage to your penis. 

How effective is Trimix for treating erectile dysfunction?

In studies of men who did not receive satisfactory treatment with oral ED options like Viagra, Trimix injections were shown to have between 80% to 95% satisfaction, depending on the study.  Results were generally more positive with Trimix than with any of its three primary constituent active ingredients alone.  While it does not cure any underlying issues that resulted in erectile dysfunction (neither do oral tablets), it can be a highly effective treatment for most men (Coombs et al., 2012).

Is Trimix safe to use?

So long as the precautions, proper injection techniques, dosage, and frequency of use considerations are observed, Trimix is safe as a treatment for ED.  However, as an injection, it certainly has a greater potential for some complications, such as injection site infections, when compared to oral medication.  Overdose or too-frequent-use can result in priapism and may cause permanent damage to the penis.  Therefore, it’s important to ensure you fully understand the dosage and injection instructions, follow them closely, and discuss any concerns with your doctor, among other important considerations. 

Concluding Thoughts

If you are a man who has tried oral erectile dysfunction treatments without success, there is hope – Trimix injections.  They are highly effective as a treatment of last resort for the vast majority of men who have tried them.  While there are some risks, and Trimix is not available without a prescription, that doesn’t mean your only option for where to buy Trimix is through your doctor and local pharmacy.  Telemedicine providers like Invigor Medical, along with their associated online pharmacies, can be the ideal choice – giving you all the advantages and none of the disadvantages of your other options for where to buy Trimix.  Most importantly, they provide a quick, easy, and affordable way to get the Trimix injections you need to maintain or regain a satisfactory sex life.    

ALSO READ – Improve Your Sex Drive After 50


While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider.  You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 


  1. Harvard Health. (2013). When drugs for erectile dysfunction don’t work: What’s next? Retrieved from
  2. Seyam, R., Mohamed, K., Akhras, A. et al. A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1Int J Impot Res 17, 346–353 (2005).
  3. Coombs, P. G., Heck, M., Guhring, P., Narus, J., & Mulhall, J. P. (2012). A review of outcomes of an intracavernosal injection therapy programme. BJU International110(11), 1787–1791.

Learn more about the risks of purchasing ED medications without a prescription.


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