Skip to main content

Semaglutide Reviews: How Effective Is It Really?

Jun 5, 2022
Semaglutide Reviews: How Effective Is It Really?

Wegovy (semaglutide) is a prescription injectable medication that is U.S. Food and Drug Administration (FDA) approved for weight management. Novo Nordisk is the manufacturer of Wegovy and the following medications, which all contain semaglutide.

  • Ozempic
  • Rybelsus
  • Liraglutide

Semaglutide reviews indicate that it is a very effective weight-loss medication. While the gastrointestinal side effects associated with semaglutide use can cause some people to discontinue treatment, overall, the side effects are temporary and mild to moderate in intensity.

Do Weight-Loss Treatments Work?

Based on the results of the Semaglutide Treatment Effect in Obese People (STEP) clinical trial, the FDA gave Wegovy (semaglutide) its approval for treating obesity. The STEP clinical trials were a series of four 68-week randomized, double-blind clinical trials that enrolled approximately 4,500 people who were overweight or had obesity.

Participants in the STEP trials lost between 15% and 17% of their body weight. For medications that are approved for weight management, the effectiveness and results threshold for FDA approval is set at 5% weight loss. Wegovy exceeded this threshold. Participants also had several other benefits, including better lipid profiles, smaller waist circumferences, better glucose utilization, and better lipid levels.

There are currently 236 studies registered on that mention semaglutide. These trials test semaglutide’s effects on cardiovascular disease, diabetes, kidney disease, and liver disease at various dosages in populations worldwide and for patients within different age groups.

When researchers surveyed 1,850 adults with obesity from six Western European countries, they found that the majority of the adults surveyed were actively trying to lose weight but were unsuccessful.

  • 72% had tried calorie-restricted or calorie-controlled diets
  • 22% tried exercise programs or classes
  • 12% used pharmaceutical weight-management drugs

A third of respondents said they had meaningful weight loss (defined as at least 5% body weight)—another third experienced weight gain of 5% or more. However, only 20% of people had success with calorie-restricted diets or exercise programs, making them the least successful diet-management strategy for weight loss.

Finding an effective weight-loss treatment is essential. Many people have one or more obesity-related conditions. These conditions adversely impact your overall health and can shorten your lifespan.

Participants in the survey had the following obesity-related conditions:

  • High blood pressure: 39%
  • High lipids or high cholesterol levels: 23%
  • Type 2 diabetes: 18%
  • Osteoarthritis: 16%

It’s important to note that Novo Nordisk sponsored the survey.

Does Wegovy Work?

Clinical trial results and patient reviews support the effectiveness of Wegovy (semaglutide). Glucagon-like peptide 1 (GLP-1) analogues, like Wegovy, bind to receptors in the brain to decrease hunger and cravings. They also bind to receptors in the stomach to slow stomach emptying and digestion. Slowing stomach emptying makes you feel full longer, but it can cause heartburn, gas, nausea, and constipation in susceptible people.

GLP-1 also binds to receptors in the pancreas. This makes the pancreas release insulin, which lowers blood sugar. Natural GLP-1 in the body only lasts for about 90 seconds. Synthetic GLP-1s can last a week, continuing to suppress your appetite.

Semaglutide reviews: Doctor getting patient review

What Are Wegovy’s Side Effects? 

Gastrointestinal symptoms were the most common side effects.

Other common side effects associated with Wegovy (semaglutide) use (and their percentages in clinical trials) include:

  • Nausea (44%)
  • Diarrhea (30%)
  • Vomiting (24%)
  • Constipation (24%)
  • Stomach pain (20%)
  • Headache (14%)
  • Fatigue (11%)
  • Heartburn (9%)
  • Dizziness (8%)
  • Stomach bloating (7%)
  • Burping/flatulence (7%)
  • Low blood sugar in people with type 2 diabetes (6%)
  • Gas (6%)
  • Gastroenteritis (6%)
  • Acid reflux (5%)
  • Stomach irritation (4%)
  • Viral gastroenteritis (4%)
  • Hair loss (3%)

In the STEPS clinical trials, 5.8% of patients taking Wegovy and 11.6% of patients taking a placebo discontinued treatment due to side effects.

More serious side effects that you should report to your doctor or health care professional as soon as possible include:

  • Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • Vision changes
  • Fast heartbeat
  • Gallbladder problems
  • Low blood sugar levels
  • A lump or swelling in the neck
  • Pancreatitis
  • Suicidal thoughts and depression
  • Trouble breathing
  • Trouble swallowing

Semaglutide users suggest the following to decrease gastrointestinal side effects:

  • Avoid sugary drinks
  • Avoid overeating
  • Walk a lot to increase GI motility and help prevent constipation
  • Drink plenty of water
  • Reduce or stop alcohol use
  • Reduce carbohydrates
  • Eat smaller, more frequent meals
  • Choose bland foods
  • Eat slower and chew food thoroughly

Many people taking semaglutide say that side effects improved as they continued with the medication. However, others said they needed to go back to a lower dose to reduce side effects.

Semaglutide Reviews

According to, semaglutide weight loss reviews are positive, with most reviewers rating their satisfaction with the drug at 7.2 out of 10. Reviewers mention gas, diarrhea, and stomach upset as common side effects. Some say the side effects are manageable if they change their diet. Others find them intolerable and discontinue the medication.

Nearly all reviewers are happy with the weight loss they have experienced and say that their cravings for unhealthy foods have all but disappeared. Many said they have reduced appetite and no longer think about food all day. semaglutide weight loss reviews rate Wegovy (semaglutide) a 4 out of 5. Wegovy scores are high on effectiveness and ease of use. Overall satisfaction was rated slightly lower. Common concerns include an inability to access Wegovy, nausea, diarrhea and constipation, and hair loss.

doctor and patient

Final Thoughts on Semaglutide Reviews

Semaglatide is a GLP-1 analogue that effectively induces weight loss by telling your brain that you are full. Clinical trials demonstrate its effectiveness. Since its effect is dose-dependent, Wegovy is at a higher dose than other semaglutide medications that are used to treat type 2 diabetes, which may contribute to its increased side effect frequency.

An escalating dose allows your body time to get used to the medication. The most common side effects are gastrointestinal. Some people have minimal side effects, others have side effects that are managed with changes in diet or lifestyle, and about 5% to 6% of people need to discontinue semagl;utide because of the side effects. The side effects occur less frequently than with other weight loss medications.

Semaglutide works for most people by reducing appetite and cravings. In clinical trials, participants lost an average of 15% of their body weight, compared with 2.4% weight loss among those receiving placebo.

Semaglutide is indicated for use in adults with an initial body mass index (BMI) of

• 30 kg/m2 or greater (obesity) or

• 27 kg/m2 or greater (overweight) with at least one weight-related medical condition, such as high blood pressure, type 2 diabetes, or abnormal blood lipids

If you meet these criteria and are interested in trying a prescription medication for weight management, talk to one of the medical professionals at Invigor Medical to find out whether semaglutide can work for you.

Semaglutide Reviews: How Effective Is It Really?
While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

Semaglutide Reviews: How Effective Is It Really?

Leann Poston, M.D.

Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.


Fill out the form below, and one of our treatment specialists will contact you.

Featured Articles

Semaglutide Reviews: How Effective Is It Really?

The Benefits of Vitamin D3 Injections

Most people know it’s essential to go outside and get sun exposure daily. Still, you may not know why it’s essential. This is because when the sun’s ultraviolet rays reach your skin cells, it…
Semaglutide Reviews: How Effective Is It Really?

Reasons Why You Might Be Gaining Weight While Working Out

It’s January, and the gyms are jam-packed with people working out. Many people begin the New Year with resolutions to exercise daily, get in shape, and lose weight. After a few weeks, the gym…

Medication Information: Semaglutide

Everything you need to know about Semaglutide.