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Wegovy and Rybelsus For Weight Loss:  What’s The Difference?

Apr 11, 2024
Wegovy and Rybelsus For Weight Loss:  What’s The Difference?

Semaglutide, marketed under the brand names Wegovy and Rybelsus, is a prescribed medication used to manage type 2 diabetes and assist with weight management in individuals with obesity. Wegovy and Rybelsus for weight loss, what is the difference?

All semaglutide formulations used in weight loss medication are GLP-1 receptor agonists, which suppress the appetite by slowing the rate at which food moves from the stomach into the small intestine, making you feel full faster and longer. 

Wegovy and Rybelsus work the same in the body, but some differences exist. Rybelsus is an oral (taken by mouth) pill that is FDA-approved to treat diabetes.1 Wegovy is an injectable medication; it is the first glucagon-like peptide-1 (GLP-1) receptor agonist approved for long-term weight management. 

The Difference in Semaglutide Medications

The differences between the various semaglutide weight loss products can be confusing. Here are the primary differences:

  • Wegovy and Ozempic are semaglutide injections; Rybelsus is a tablet. 
  • Wegovy and Ozempic are taken once weekly; Rybelsus is taken daily. 
  • Wegovy is FDA-approved for chronic weight management; Rybelsus and Ozempic are approved to treat type 2 diabetes.
  • Wegovy comes in a higher dose (2.4 mg) than Ozempic (0.25-1mg). Rybelsus dosage varies from 3mg to 14 mg. 

Wegovy and Rybelsus for Weight Loss: What’s the Difference?

Wegovy and Rybelsus for Weight Loss

Like all forms of semaglutide, Wegovy and Rybelsus suppress the appetite, which results in weight loss. All forms of semaglutide also stimulate the pancreas to secrete insulin, which lowers blood sugar. Wegovy and Rybelsus are glucagon-like peptide 1 (GLP-1) agonists. GLP-1 is a hormone that controls appetite and hunger by binding to brain receptors. 

Wegovy weight loss

Ozempic and Wegovy are injectable forms of semaglutide, but they are not the same. Because Ozempic was shown to cause weight loss in clinical trials, researchers began testing high-dose forms of semaglutide to treat obesity. Wegovy, an injectable form of semaglutide with a higher maximum dose (2.4mg) than Ozempic, was developed specifically to treat obesity. Wegovy was FDA-approved in June 2021.

In the Wegovy clinical trials, adults with obesity or who were overweight with a weight-related medical condition received either Wegovy or placebo, along with a reduced-calorie diet and exercise plan. After 68 weeks, study participants taking Wegovy had an average weight loss of 14.9%, compared with 2.4% in the placebo group.2  

Smiling Friendly Athletic Middle-aged Man Standing Holding A Bottle

Rybelsus weight loss

Rybelsus is an oral pill taken daily that is approved to treat type 2 diabetes in adults. Although the FDA hasn’t approved it for weight loss, doctors often prescribe Rybelsus as an off-label drug (i.e., one that is given for a condition other than FDA-approved use) to help with weight control. Higher doses of Rybelsus are being studied for the drug’s effect on weight loss. Initial results suggest it may result in an average of 15% body weight loss.3 

Rybelsus Weight Loss Reviews and Studies

Rybelsus weight loss reviews

Of 196 reviews on Drugs.com, nearly half of Rybelsus reviewers reported a positive experience.4  It’s important to note that most of the reviewers took Rybelsus for type 2 diabetes, and many were on several antidiabetic medications along with Rybelsus. Here are a few reviews from people who take Rybelsus for weight loss: 

1. Soso – Reports initially feeling nauseated when taking Rybelsus, but it dissipated by the third day of taking the medication. By day three, Soso said, “I could tell I wasn’t as hungry as before. I don’t look for snacks, I don’t overeat my dinner, and I get full faster.” Soso reports losing 25 lbs. after taking the medication for under two months.  

A woman holding up a card that says "Portion Control"

2. Pauline: “I have lost 1 stone [14 lbs.] exactly after 7 weeks on Rybelsus. I have next to no symptoms, occasional heartburn, and a sudden dislike for my morning coffee.” Pauline says she’s satisfied eating under 1400 calories daily and has a BMI of 25 for the first time in 10 years. She also mentions losing her food obsession and rarely feeling hungry.

3. Tom—weighed 345 lbs. He reports, “Doc made it clear my blood work was unacceptable for a 42-year-old (A1C was 6.4, fatty liver diagnosis, and borderline cholesterol).” After two months, Tom states his A1C is down to 5.5, he lost 25 lbs., and his cholesterol and liver enzymes are back to normal. 

Rybelsus study

In a randomized, double-blind, placebo-controlled clinical trial, the gold standard of medical studies, 667 people with obesity were given either a 50 mg Rybelsus oral (by mouth) tablet or a placebo (sugar pill) each day for 68 weeks. The average weight loss at the end of the study was 15.1% for the group that took oral semaglutide (Rybelsus) 50 mg daily. The placebo group lost only 2.4% of their body weight.5 

Male waist measuring tape

The study authors wrote, “In adults with overweight or obesity without type 2 diabetes, oral semaglutide 50 mg once per day led to a superior and clinically meaningful decrease in body weight compared with placebo.” 5

Wegovy weight loss reviews and studies

Wegovy weight loss reviews

Wegovy reportedly has an average rating of around 7.2 out of 10 from 312 online reviews for obesity treatment.6 Samples of real-life scenarios from Wegovy users include:6 

  1. Mike—Mike had been taking Wegovy for four months at the time of the review; Mike stated that the “drug has been life-changing.” Mike was 357 lbs. when he started taking Wegovy 2.4 mg, and at the four-month mark, he reported having lost 60 lbs. Mike reported some minor gastrointestinal side effects (heartburn and stomach upset) early on, which have since subsided. 
  2. 2. Kelly—”I have been on Wegovy for almost seven weeks and have lost over 22 lbs.,” Kelly reports. She says her weight loss progress is steady without dieting or exercising. Kelly denies having experienced any “bad side effects” from taking Wegovy. “From the moment I took the first injection, the food noise was gone,” she says. 
  3. Anonymous- “I have been on Wegovy for over a month now; it has been a life changer for me.” This anonymous reviewer of Wegovy says they have lost nearly 14 lbs. since starting on Wegovy, limiting eating hours to 6:00 a.m. and 3:00 p.m. and walking 1/2 mile daily during lunch breaks. 

Wegovy weight loss study

In clinical trials, people who took Wegovy lost an average of 35 lbs., or 15% of their body weight.7 In addition to losing significant weight, the study participants maintained weight loss over time. 

Wegovy weight loss before and after pictures

You can view Wegovy weight loss before and after pictures on Pinterest here

Infographics Semaglutide

Conclusion

At Invigor Medical, you can buy semaglutide via our simple approval process. This process involves selecting the treatment plan you want, completing an online medical form, and consulting with a licensed physician online.  A bundled semaglutide weight loss package includes a doctor’s consultation, the medication, and all required medical equipment, which will be delivered directly to your door by one of our pharmacy partners.

Frequently Asked Questions

How quickly do you lose weight on Rybelsus?

The rate of weight loss on Rybelsus can vary among individuals. Clinical studies have shown that significant weight loss may occur within the first few months of treatment, with continued weight reduction over time. However, individual responses may differ, and factors such as adherence to medication, diet, exercise, and other health conditions can influence weight loss outcomes.

Is there a difference between Rybelsus and Wegovy?

Yes, there is a difference between Rybelsus and Wegovy. Both medications contain the active ingredient semaglutide, but they are indicated for different purposes. Rybelsus is an oral formulation of semaglutide approved for the treatment of type 2 diabetes, while Wegovy is a higher-dose injectable formulation of semaglutide approved for chronic weight management in adults with obesity or overweight who have at least one weight-related comorbidity.

Do people lose more weight on Rybelsus or Ozempic?

Both Rybelsus and Ozempic (another brand name for semaglutide) have been shown to promote weight loss in clinical trials. The extent of weight loss may vary among individuals and depends on various factors such as dosage, adherence to treatment, diet, exercise, and individual metabolic factors. Comparing the effectiveness of Rybelsus and Ozempic in promoting weight loss would require a head-to-head clinical trial.

Does Rybelsus help you lose belly fat?

Rybelsus has been shown to lead to significant reductions in visceral adipose tissue (belly fat) in clinical studies. Belly fat reduction is often associated with improvements in metabolic health and a decreased risk of obesity-related complications. However, individual responses may vary, and the extent of belly fat loss may depend on factors such as dosage, duration of treatment, lifestyle modifications, and individual metabolic characteristics.

Disclaimer
While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

References

  • Rybelsus semaglutide tablets. Prescribing Information. https://www.novo-pi.com/rybelsus.pdf
  • Novomedlink. Wegovy semaglutide injection 2.4. https://www.novomedlink.com/obesity/products/treatments/wegovy.html
  • Beasley, D. Reuters. (2023). Novo Nordisk says obesity pill leads to 15% weight loss; availability ‘to be determined’. https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-says-obesity-pill-leads-15-weight-loss-availability-be-determined-2023-06-26/
  • Drugs.com. Rybelsus User Reviews & Ratings. https://www.drugs.com/comments/semaglutide/rybelsus.html
  • Knop FK, Aroda VR, do Vale RD, et al. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomized, double-blind, placebo-controlled, phase 3 trial. The Lancet. 2023;402(10403):705-719. doi: 10.1016/S0140-6736(23)01185-6. https://doi.org/10.1016/S0140-6736(23)01185-6
  • Drugs.com. Wegovy for Anti-obesity Medications for Weight Loss (Obesity/Overweight) User Reviews. https://www.drugs.com/comments/semaglutide/wegovy-for-obesity.html?page=3
  • Novemedlink. Wegovy (semaglutide) injection 2.4 mg. https://www.novomedlink.com/obesity/products/treatments/wegovy/efficacy-safety/clinical-trial-1-results.html

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