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The Benefits of Semaglutide for Weight Loss: Is It Effective?

Mar 26, 2024
The Benefits of Semaglutide for Weight Loss: Is It Effective?

The prevalence of obesity has reached worldwide epidemic proportions, with at least 2.8 million people dying yearly due to complications from  being overweight or having obesity, according to the World Health Organization (WHO).1  Weight loss programs are nothing new, particularly in the U.S., where nearly half of all Americans are known to attempt to lose weight each year, according to the Centers for Disease Control and Prevention (CDC).

 It is no surprise that new and improved online weight loss programs keep emerging. Although there never seems to be a shortage of unreliable claims about quick and easy weight loss remedies, some online platforms offer weight loss treatment modalities—such as semaglutide— that are breaking new ground. Read on to learn what many patients and scientific researchers say about semaglutide for weight loss.

What Is Semaglutide?

Semaglutide is a weight loss medication classified as a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 drugs mimic the action of a hormone in the body–called GPL-1 hormone–that lowers blood sugar by increasing insulin secretion.3

Initially, GLP-1 drugs treated type 2 diabetes and were prescribed with diet and exercise to help control blood sugar.4 But you don’t have to be diabetic to take semaglutide; many doctors prescribe this weekly injectable weight-loss drug for non-diabetic people who are overweight or have obesity. Semaglutide’s popularity is gaining momentum as a growing body of medical research shows its many benefits.

Dosage of Semaglutide for Weight Loss in Nondiabetics

The initial dose of semaglutide for weight loss in nondiabetics is 0.25 mg for four weeks. The dosage is slowly increased until you reach the maintenance dose of 2.4 mg per week.5

Image of an empty vial

This medicine is given as an injection subcutaneously (under the skin), rotating the injection site each time you give yourself the shot in the stomach, upper arms, or thighs. 

The semaglutide for weight loss in nondiabetics dosage is typically slightly higher than the dose used to treat type 2 diabetes. 

Benefits of Semaglutide

Today, semaglutide is well-known for helping people lose weight and keep it off, particularly in cases of obesity caused by specific conditions.

The weight loss medication helps you lose weight by decreasing your appetite; other benefits of semaglutide include:

  • Increases the feeling of fullness after a meal
  • Reduces food cravings 
  • Lowers blood sugar levels
  • Increases insulin sensitivity (allows cells to use blood glucose more efficiently)
  • Lowers the risk of type 2 diabetes
  • Lowers the risk of stroke or heart attack, some cancers, and diabetes
  • Lowers blood pressure
  • Reduces triglycerides
  • Improving cholesterol levels

Side Effects of Semaglutide

Common side effects of semaglutide observed in studies include:

  • Headache, dizziness, and fatigue
  • GI disturbances, such as heartburn, nausea, vomiting and bloating
  • Constipation or diarrhea
  • Stomach pain
  • Redness, itchiness, pain, or swelling at the injection site

Rare, severe side effects may include:

  • Low blood sugar
  • Increased heart rate
  • Gallstones
  • Possible risk of certain thyroid tumors
  • Kidney problems
  • Inflammation of the pancreas
  • Depression or suicidal thoughts
  • Other symptoms*
A woman who has experienced weight loss

*Other severe side effects associated with semaglutide injections include symptoms of allergic reactions. Seek emergency medical care if you experience difficulty breathing, hoarseness, or swelling of your hands, mouth, or throat.

Semaglutide Weight Loss Safety and Effectiveness

Clinical trials showed that study participants taking semaglutide lost between 5% and 20% of their body weight.

A 2022 Review Study on Semaglutide Weight Loss

A 2022 review study evaluated semaglutide for its safety and effectiveness in obesity treatment for people without diabetes. The study concluded that semaglutide, given via subcutaneous injection, resulted in an 11.85% weight reduction compared to those who took a placebo (sugar pill).

A 2021 Study on Semaglutide Effectiveness

A 2021 study on the safety and effectiveness of semaglutide discovered that after just 17 months of taking a weekly semaglutide injection, the average weight loss was around 30 pounds. The study authors wrote, “In participants with overweight or obesity, 2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained clinically relevant reduction in body weight.” 8

A scale, weights, apple and tape measure

A 2021 Study on Semaglutide Safety

A 2021 study examined the safety of semaglutide oral and injectable and discovered that most of the side effects were mild, temporary GI (gastrointestinal) disturbances and an increased risk of gallstones. The study authors wrote,” No major safety concerns have arisen to date.” 9

Semaglutide Weight Loss Reviews

Online semaglutide weight loss reviews portray the safety and effectiveness of the drug and provide good information on consumer experiences. Examples of semaglutide weight loss reviews on include:10

  • “First 2 weeks I had some mild nausea, nothing terrible and some mild dizziness. The past 2 weeks I have had no symptoms. I am doing the weekly injection at 0.25 along with Weight Watchers and in the past 26 days I have lost 10.5 lbs.”
  • “I’m so happy to say I’ve had zero side effects except a disinterest in food. I’m on week six of the 0.25 dose. My lack of interest in food is liberating!”
  • “I started at a size 16 and 213lbs. After a little over a year, I am now 125lbs and a size small. This drug literally reset my entire body chemistry and metabolism.”

*reviews edited slightly for length

Semaglutide for Weight Loss

Do I Qualify For The Semaglutide Weight Loss Program

Enrolling in a weight loss program at Invigor Medical is simple, but there are some prequalifications you must meet. For example, you must have a body mass index (BMI) of:

30 or higher, or 27 or higher, along with a weight-related medical condition such as high blood pressure.  

The BMI measures body fat based on height and weight. The BMI requirement for treatment applies to adult men and women. A medical consultant at Invigor will help you estimate your BMI to see if you qualify for the program, or use this helpful BMI calculator.

Infographics Semaglutide

Semaglutide Weight Loss Near Me

If you are searching for a semaglutide weight loss clinic in your local area, look no further; you don’t have to Google “semaglutide weight loss near me.” Invigor Medical is a national telehealth wellness clinic that offers weight management, sexual health, and longevity-related health programs online. Our treatment plans are bundled, so you receive all the services you need (e.g., medical consultations, prescription medication, and supplies) at one cost. The sign-up process is simple: you select the medication you want to purchase, consult online with one of our licensed physicians, and, if approved, your medication is mailed directly to your home. Find your plan and get started today.

Frequently Asked Questions

How much weight can I lose in a month on semaglutide?

The amount of weight you can lose in a month on semaglutide varies depending on factors such as your starting weight, diet, exercise, and overall health.

Is semaglutide worth it for weight loss?

The effectiveness of semaglutide for weight loss varies from person to person. It’s essential to discuss its benefits and risks with your healthcare provider to determine if it’s worth it for you.

How much does semaglutide cost per month?

The cost of semaglutide per month can vary based on factors such as your insurance coverage, dosage, and pharmacy. It’s best to check with your insurance provider or pharmacy for specific pricing information.

How long can I stay on semaglutide for weight loss?

The duration you can stay on semaglutide for weight loss depends on individual factors and should be determined by your healthcare provider based on your response to treatment and any potential side effects.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.


  • The World Health Organization (WHO). (2021) Obesity.
  • The Center for Disease Control and Prevention. Attempts to Lose Weight Among Adults in the United States, 2013–2016
  • U.S. Food and Drug Administration (FDA). Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss
  • Pharmacy Times. (2024). FDA Approves Semaglutide for New Indication Involving Cardiovascular Disease.
  • Chao AM, Tronieri JS, Amaro A, Wadden TA. Semaglutide for the treatment of obesity. Trends Cardiovasc Med. 2023;33(3):159-166.
  • Ghusn W, De la Rosa A, Sacoto D, et al. Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity. JAMA Netw Open. 2022;5(9):e2231982. doi: 10.1001/jamanetworkopen.2022.31982
  • Department of Medicine, St. Luke’s Medical Center, Quezon City, Philippines, Tan HC, Dampil OA, Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, St. Luke’s Medical Center, Quezon City, Philippines, Marquez MM, Department of Medicine, St. Luke’s Medical Center, Quezon City, Philippines. Efficacy and safety of semaglutide for weight loss in obesity without diabetes: a systematic review and meta-analysis. JAFES. 2022;37(2):65-72. doi: 10.15605/jafes.037.02.14
  • Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989-1002. doi: 10.1056/NEJMoa2032183
  • Smits MM, Van Raalte DH. Safety of Semaglutide. Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. Erratum in: Front Endocrinol (Lausanne). 2021 Nov 10;12:786732
  • (2024). Semaglutide User Reviews & Ratings.


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