Trimix is an injectable medication used to treat erectile dysfunction. Trimix injections are a mixture of three drugs: phentolamine, papaverine, and alprostadil. Trimix is considered a second-line medication to treat ED for men who cannot take phosphodiesterase inhibitors, have had severe side effects, or who have not had successful results when taking these oral ED medications. The three medications in Trimix work synergistically to increase blood flow to the penis.

Based on clinical studies, the success rate for Trimix when treating ED is 80-95%.

Trimix does not cure ED, affect the libido, prevent pregnancy, or protect against sexually transmitted diseases such as human immunodeficiency virus.

There are no secondary uses for Trimix.

Do not use Trimix injections more than two to three times a week.(sources differ on this) Each Trimix injection should be at least 24 hours apart.

Trimix dosage is usually started at .05cc (5 units) and gradually increased in consultation with a health care provider. Trimix dosages are sometimes written in cubic centimeters (cc), units, or milligrams (mg). These dosage units are not equivalent Dosage should never be more than 1 dose in 24 hours, never more than two days in a row or more than three times in a week. If dosage is given in units most prescribers will start with 15 to 25 units or (15 to 25 mcg) per dose. The dose is increased 5 units at a time to a maximum of 50 units. The injection should be done at mid-shaft at the 10 oclock or 2 oclock position and on alternating sides to decrease teh risk fo scarring.

Trimix typically induces an erection within about 5 minutes of injection. The erection may improve over the next 20 minutes.

An erection from Trimix generally lasts between 30 minutes and one hour.

As with all medications for ED, you should not use Trimix if you have ever been told by a health care provider that your heart is not healthy enough for sexual activity. Trimix should not be taken with any oral ED mediations. Before using Trimix, advise your health care provider if you:
• Have a hypersensitivity or an allergy to any component in the formulation.
• Have a condition that predisposes you to priapism (a painful erection lasting over 4 hours)
• Have sickle cell anemia, multiple myeloma or leukemia
• Have an anatomical deformity of the penis
• Are taking any medications that interfere with blood clotting. Are taking any medications, herbs, nonprescription drugs, or supplements, especially medications for high blood pressure, medications for depression or classified as a MAO inhibitor such as phenelzine or a sleep aid such as trazadone.
Trimix and oral ED medications: Do not take Sildenafil, Vardenafil or Avenafil within 18 hours (before or after) an injection. Do not inject within 72 hours of taking tadalafil 10 mg or 20 mg.

No required dosing schedule is needed when using Trimix for erectile dysfunction except not to inject more than one dose in 24 hours and not more than three times per week.

Trimix is not stable for long periods. Frozen preparations are stable for six months to a year. Store dry powder at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Once reconstituted keep Trimix in a refrigerator between 36°F to 46°F (2°C to 8°C). Keep all medicine out of the reach of children.

Ask your health care provider or pharmacist how this medication should be properly disposed.

None

There are no specific dietary restrictions when using Trimix.

An overdose of Trimix can cause priapism (a painful erection lasting more than four hours). Contact your health care provider for treatment instructions.