Tadalafil/Phentolamine from Invigor Medical

Buy Tadalafil/Phentolamine

Tadalafil/Phentolamine, prescribed by specialists, filled by an FDA-registered pharmacy

Licensed Physicians
Licensed Physicians
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Legitimate Pharmacies
Prescription Included
Prescription Included
Licensed Physicians
Licensed Physicians
Legitimate Pharmacies
Legitimate Pharmacies
Prescription Included
Prescription Included
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Purchase Tadalafil/Phentolamine

Buying Tadalafil/Phentolamine from Invigor Medical guarantees that you are working with a licensed, experienced, and dedicated doctor and receiving Tadalafil/Phentolamine from a US-based, FDA 503B-registered pharmacy.
Treats ED
Proven treatment for erectile dysfunction

Single Purchase
5 Count
Single Purchase
30 Count

What is Tadalafil/Phentolamine?

Erectile dysfunction is the inability to get and maintain an erection satisfactory for penetrative sex. The most common physical cause of erectile dysfunction is damage to blood vessels entering the penis due to high cholesterol, diabetes, and high blood pressure. ED medications, such as Tadalafil and Phentolamine, dilate blood vessels allowing more blood to enter and fill the corpora cavernosa in the penis.

Tadalafil is a phosphodiesterase (PDE) class 5 inhibitor. Medications in this class are used to treat erectile dysfunction, pulmonary artery hypertension, benign prostatic hypertrophy (BPH), or the concurrent treatment of erectile dysfunction and BPH.

Tadalafil (generic for Cialis) is a lower-cost option for Cialis that contains the same active ingredients. It works exactly the same way as the brand-name medication in your body. In contrast to other oral ED medications, tadalafil provides two convenient treatment dosing options: once daily and as needed.

Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa allowing it to fill with blood producing an erection. Tadalafil and phentolamine work via different mechanisms to maximize blood flow into the penis.

What is Included?

  • MEDICAL CONSULTATION: Discuss your treatment plan with one of our licensed Practitioners.
  • MEDICATIONS / SUPPLEMENTS: All medications and supplies are included. No Hidden Fees.
  • KNOWLEDGEABLE STAFF: Our medical staff are well trained and ready to answer your questions.

Compounds in the Medication

Learn More
Learn More

Included Supplies

  • Tadalafil/Phentolamine Tablets Delivered Discreetly

Signs You Might Need This Treatment Plan


You may be experiencing a combination of the following symptoms
  • Erectile Dysfunction
If you are experiencing any of the symptoms listed above, please fill out our medical forms. After that, an Invigor Medical specialist will contact you.

How Does Tadalafil/Phentolamine Work?

Tadalafil is a Phosphodiesterase Type 5 Inhibitor

Nitric oxide is a small molecule found throughout the body. It is released from nerve endings near the blood vessels in the corpus cavernosum of the penis after sexual stimulation. Nitric oxide triggers a chemical cascade that dilates blood vessels and increases blood flow into the penis, resulting in an erection. cGMP (another chemical in the cascade) levels must remain high to maintain the erection. Phosphodiesterase inactivates cGMP. When cGMP is deactivated, the smooth muscles in the walls of small blood vessels contract, reducing blood flow and ending the erection.

Oral ED medications, such as tadalafil, are phosphodiesterase inhibitors. By inhibiting phosphodiesterase, nitric oxide continues to trigger the cascade, and blood flow into the penis is maintained, meaning a firm erection that persists. Understanding this cascade led to the development and subsequent FDA approval of tadalafil in 2003.

Phentolamine is a Vasodilator

Phentolamine is an alpha-adrenoceptor antagonist, which means that it blocks chemicals that bind to alpha-adrenergic receptors. Competitively binding to their receptors, phentolamine causes muscle relaxation and a widening of blood vessels. When blood vessels are widened, blood pressure decreases, and blood flow into the penis increases. Phentolamine also blocks 5-HT receptors, which cause the release of histamine from mast cells.

Benefits of Tadalafil/Phentolamine

Tadalafil and phentolamine are two proven treatment options for erectile dysfunction. They work via different mechanisms to maximize blood flow into the penis to produce an erection.

  • Improves Erectile Function
  • Increases Confidence

Included with the Plan

No Hidden Fees

Free Doctor Consult

The consultation with the practitioner is always included when you buy Tadalafil/Phentolamine.

Medical Support

Medical Support

Our friendly staff are knowledgeable and available to answer any questions.

Supplies Included

Supplies Included

When you purchase Tadalafil/Phentolamine, all required supplies are always included.

No Doctors Office Visit Required

No Doctor’s Office

Skip the in person doctor’s visit and consult remotely, and get Tadalafil/Phentolamine shipped direct.

Licensed Pharmacies

Licensed Pharmacies

Our US based, FDA registered pharmacies provide quality meds tested for purity and potency.

Free Doctor Consultation

Licensed Doctors

Our licensed doctors cover all 50 states and are very well versed with the medications we offer.

Tadalafil/Phentolamine FAQ’s

The Plan
Is phentolamine used for erectile dysfunction?

Yes, phentolamine is used to treat erectile dysfunction. It causes blood vessels to dilate, increasing blood flow into the penis, producing an erection.

Phentolamine is an alpha-blocker, which produces an erection in 20 to 30 minutes. The drug is generally well-tolerated. The most common side effects are headaches and lightheadedness.

What medications should not be taken with tadalafil?

Tell your doctor about all medications you are taking, especially the ones listed below, as they are likely to interact with tadalafil:

  • Other ED medications in the same class (avanafil, sildenafil, and vardenafil)
  • Drugs that are used to treat blood pressure
  • Drugs used to treat prostate disorders
  • Antibiotics such as clarithromycin, erythromycin, and others
  • Antifungal medications such as ketoconazole and itraconazole
  • Medications used to treat HIV/AIDS
  • Seizure medications such as carbamazepine or phenytoin
What can cause tadalafil to stop working?

Tadalafil is a phosphodiesterase inhibitor that increases blood flow into the penis. Medical conditions that cause further damage to the inner lining of blood vessels can limit tadalafil’s effectiveness.

Potential reasons tadalafil is not working well to treat ED:

  • The incorrect dose is used
  • The medication is past its expiration date
  • You have not waited for 30 to 60 minutes for tadalafil to reach its full effect
  • A dosage adjustment is not made for men with poorly controlled diabetes, obesity, kidney disease, or high blood pressure (a higher dosage may be needed)
  • Hormonal issues such as low testosterone or high prolactin
When is the best time to take tadalafil?

Tadalafil is taken on an as-needed basis, a minimum of 30 minutes before anticipated sexual activity, and never more than once daily.

Is tadalafil good for the heart?

Tadalafil is a PDE 5 inhibitor that increases nitric oxide and blood flow. In addition to treating ED, it also has beneficial cardiovascular effects. It can improve heart muscle contractility and blood flow and can be beneficial for:

  • Coronary artery disease
  • High blood pressure
  • Heart failure
  • Pulmonary artery hypertension
  • Diabetes mellitus
Can I drink alcohol with tadalafil?

Tadalafil can cause side effects such as headaches and flushing because of its effects on blood vessels. Alcohol can make these side effects worse, and therefore alcohol and tadalafil should not be used together.

Does grapefruit juice make tadalafil stronger?

Grapefruit and grapefruit juice affect how tadalafil is metabolized. Grapefruit juice can decrease the metabolism of tadalafil and increase its level in the blood. Grapefruit will decrease the enzyme CYP3A4, which breaks down tadalafil and releases it in a controlled dosage in your body.

Grapefruit can take 72 hours to metabolize. Do not consume grapefruit while taking tadalafil.

Potential side effects of combining grapefruit and tadalafil:

  • Redness
  • Flushing
  • Headache
  • Vision changes
  • Shortness of breath
  • Irregular heartbeat


How long does phentolamine last?

Peak drug levels of phentolamine are achieved in about 15 minutes to 45 minutes. The duration of action for phentolamine is about 1 to 2 hours and the drug’s half-life is about 2 hours.

Invigor Medical
Do I need a prescription before I buy from Invigor Medical?
No, Invigor Medical employs doctors licensed in all 50 states, and a medical consultation is included with each medical service. Each patient will recieve a valid prescription which is sent to the pharmacy to be filled.
How long does it take to get my medication?
Once you have enrolled for medical services with Invigor Medical, it usually takes 3-7 work days before items arive at your home. This process includes an online medical consult, prescription approval, the medication getting filled at the pharmacy, and the medication sent to your home.
How do I know if I will be approved?
Most of the services that Invigor Medical offers are elective services. This means that most clients, if there are no restrictive contraindications, will be approved for the medications of their choice.
More Questions?
Fill out the form below, and one of our treatment specialists will contact you.
Tadalafil/Phentolamine Reviews
  • Summary Report: Tadalafil
  • Erectile Dysfunction: AUA Guideline (2018)
  • Tadalafil (Medline Plus)
  • Oral Phentolamine as Treatment for Erectile Dysfunction
  • Oral phentolamine: An Alpha-1, Alpha-2 Adrenergic Antagonist for the Treatment of Erectile Dysfunction
  • Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation
  • What is the Role of Phentolamine in the Treatment of Erectile Dysfunction (ED)?
  • Eli Lilly's Erectile Dysfunction Drug Cialis Shows Signs of Reversing Heart Failure in Sheep
  • The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats
  • Long-Term Safety and Efficacy of Oral Phentolamine Mesylate (Vasomax®) in Men With Mild to Moderate Erectile Dysfunction
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At What Age Does Erectile Dysfunction Start?
Erectile dysfunction is the inability to get and maintain an erection firm enough for satisfactory sexual performance. An isolated incident of ED is normal and is common; however, approximately 18...
Is There a Cure for Erectile Dysfunction (ED)?
Erectile dysfunction is a condition that makes it difficult to achieve or maintain an erection that is firm enough for satisfactory sexual intercourse. There are many causes of erectile dysfunctio...
Diet and Exercise to Help With Erectile Dysfunction
Erectile dysfunction affects almost one in every ten men at some point in their lives. So, it is not surprising that many men, and their partners, are asking if diet and exercise can affect erecti...
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