Proven treatment for erectile dysfunction
Erectile dysfunction is the inability to get and maintain an erection satisfactory for penetrative sex. The most common physical cause of erectile dysfunction is damage to blood vessels entering the penis due to high cholesterol, diabetes, and high blood pressure. ED medications, such as Tadalafil and Phentolamine, dilate blood vessels allowing more blood to enter and fill the corpora cavernosa in the penis.
Tadalafil is a phosphodiesterase (PDE) class 5 inhibitor. Medications in this class are used to treat erectile dysfunction, pulmonary artery hypertension, benign prostatic hypertrophy (BPH), or the concurrent treatment of erectile dysfunction and BPH.
Tadalafil (generic for Cialis) is a lower-cost option for Cialis that contains the same active ingredients. It works exactly the same way as the brand-name medication in your body. In contrast to other oral ED medications, tadalafil provides two convenient treatment dosing options: once daily and as needed.
Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa allowing it to fill with blood producing an erection. Tadalafil and phentolamine work via different mechanisms to maximize blood flow into the penis.
Nitric oxide is a small molecule found throughout the body. It is released from nerve endings near the blood vessels in the corpus cavernosum of the penis after sexual stimulation. Nitric oxide triggers a chemical cascade that dilates blood vessels and increases blood flow into the penis, resulting in an erection. cGMP (another chemical in the cascade) levels must remain high to maintain the erection. Phosphodiesterase inactivates cGMP. When cGMP is deactivated, the smooth muscles in the walls of small blood vessels contract, reducing blood flow and ending the erection.
Oral ED medications, such as tadalafil, are phosphodiesterase inhibitors. By inhibiting phosphodiesterase, nitric oxide continues to trigger the cascade, and blood flow into the penis is maintained, meaning a firm erection that persists. Understanding this cascade led to the development and subsequent FDA approval of tadalafil in 2003.
Phentolamine is an alpha-adrenoceptor antagonist, which means that it blocks chemicals that bind to alpha-adrenergic receptors. Competitively binding to their receptors, phentolamine causes muscle relaxation and a widening of blood vessels. When blood vessels are widened, blood pressure decreases, and blood flow into the penis increases. Phentolamine also blocks 5-HT receptors, which cause the release of histamine from mast cells.
Tadalafil and phentolamine are two proven treatment options for erectile dysfunction. They work via different mechanisms to maximize blood flow into the penis to produce an erection.
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Yes, phentolamine is used to treat erectile dysfunction. It causes blood vessels to dilate, increasing blood flow into the penis, producing an erection.
Phentolamine is an alpha-blocker, that produces an erection in 20 to 30 minutes. The drug is generally well-tolerated. The most common side effects are headaches and lightheadedness.
Tell your doctor about all medications you are taking, especially the ones listed below, as they are likely to interact with tadalafil:
Tadalafil is a phosphodiesterase inhibitor that increases blood flow into the penis. Medical conditions that cause further damage to the inner lining of blood vessels can limit tadalafil’s effectiveness.
Potential reasons tadalafil is not working well to treat ED:
Tadalafil is taken on an as-needed basis, a minimum of 30 minutes before anticipated sexual activity, and never more than once daily.
Tadalafil is a PDE 5 inhibitor that increases nitric oxide and blood flow. In addition to treating ED, it also has beneficial cardiovascular effects. It can improve heart muscle contractility and blood flow and can be beneficial for:
Tadalafil can cause side effects such as headaches and flushing because of its effects on blood vessels. Alcohol can make these side effects worse, and therefore alcohol and tadalafil should not be used together.
Grapefruit and grapefruit juice affect how tadalafil is metabolized. Grapefruit juice can decrease the metabolism of tadalafil and increase its level in the blood. Grapefruit will decrease the enzyme CYP3A4, which breaks down tadalafil and releases it in a controlled dosage in your body.
Grapefruit can take 72 hours to metabolize. Do not consume grapefruit while taking tadalafil.
Potential side effects of combining grapefruit and tadalafil:
Peak drug levels of phentolamine are achieved in about 15 minutes to 45 minutes. The duration of action for phentolamine is about 1 to 2 hours and the drug’s half-life is about 2 hours.