Patients who get Trimix shots from Invigor Medical experience consistent results. Three important benefits are listed below.

Trimix is an injectable medication used to treat erectile dysfunction. It is a formulation of three drugs: phentolamine, papaverine, and alprostadil (prostaglandin E1), making it an excellent ED treatment alternative for men who cannot or do not want to take phosphodiesterase inhibitors, have severe side effects from oral ED medications, or have not had successful results when taking oral ED medications.

The three medications in Trimix work synergistically to increase blood flow to the penis. Based on clinical studies, the success rate for Trimix when treating ED approaches 90%.

The American Urological Association reported that 53.7% to 100% of men (depending on population) achieved a satisfactory erection with Trimix, and 46.3% to 98.8% of men were happy with their choice to use intracavernosal injections as a treatment option.

The alpha-adrenergic antagonist phentolamine relaxes the smooth muscle lining the corpora cavernosa. It is commonly used in conjunction with papaverine to treat ED. Clinical studies show that phentolamine, when combined with papaverine, dilates blood vessels entering the penis, resulting in an erection in 20 to 30 minutes.

Papaverine, one of the first injectable medications used to treat ED, is a vasodilator, which means that it dilates blood vessels and increases blood flow into the penis. Papaverine is no longer used to treat ED on its own. It is used in conjunction with phentolamine and prostaglandin to improve treatment outcomes while minimizing side effects.

Prostaglandin E1 relaxes smooth muscle surrounding blood vessels in the penis and the corpora cavernosa in the penis, allowing them to fill with blood. Blood becomes entrapped in the penis, which leads to an erection. Prostaglandin can be administered by intracavernosal injection or as pellets inserted into the urethra.

Although Trimix is a frequently prescribed injectable to treat ED and it is highly effective, it is not the only option.

Bimix: Bimix is a combination of phentolamine and papaverine. It is an excellent choice for men with sensitivity to prostaglandin E1 or who have health conditions that contraindicate its use.

Quadmix: Quadmix combines phentolamine, papaverine, atropine, and alprostadil (prostaglandin E1). Trimix is up to 95% effective in treating ED. If you are in the 5% of men, Quadmix may be a great option.

The three ingredients in Trimix – Alprostadil, Papaverine, and Phentolamine – work in combination to increase blood flow to the penis, which causes a hard erection.

Papaverine is an alkaloid that stimulates the production of cyclic adenosine monophosphate (cAMP), a molecule that relaxes the smooth muscle in the walls of blood vessels and lining the corpora cavernosa. Its mechanism is not completely understood because it appears to act on several pathways.

When papaverine is injected into the intracavernosal space of the penis, it increases blood flow, producing an erection. Papaverine also relaxes smooth muscle lining the corpora cavernosa in the penis, allowing them to fill more completely.

Prostaglandin E1 (alprostadil) is a synthetic form of prostaglandin, a potent vasodilator. Prostaglandin E1 relaxes the smooth muscle lining the corpora cavernosa in the penis by activating prostaglandin receptors and subsequently increasing cyclic monophosphate levels in the smooth muscle. This causes a decrease in calcium levels in the smooth muscles, allowing them to relax and fill with blood.

Prostaglandin E1 also relaxes the smooth muscle lining blood vessels that enter the penis, allowing for greater blood flow into the penis.

Phentolamine is an alpha-adrenoceptor antagonist, which means that it blocks chemicals such as epinephrine and norepinephrine from binding to alpha-adrenergic receptors. Competitively binding to alpha-adrenergic receptors, phentolamine causes smooth muscle relaxation and blood vessel dilation causing penile erection. When blood vessels are widened, blood pressure decreases, and blood flow into the penis increases.