Human growth hormone (HGH) is produced by the pituitary gland. It stimulates growth through childhood and adolescence and maintains muscle mass, promotes fat-burning, improves cardiovascular function and stamina, and shortens recovery time throughout adulthood. HGH levels begin to decline around age 30, resulting in the signs and symptoms associated with aging — less energy, slower metabolism, reduced muscle mass, increased abdominal fat, trouble sleeping, prolonged recovery time, and cognitive changes.

Growth hormone is secreted in small bursts throughout the day, with the biggest pulses occurring just before you go to bed for the night. Growth hormone binds to receptors throughout the body and either acts directly or through an intermediary called insulin-like growth factor 1 (IGF-1). Deeply embedded feedback loops control HGH production throughout the day. Injecting HGH would override these feedback loops and cause potentially life-threatening symptoms such as diabetes, swelling, high blood pressure, and heart failure.

Sermorelin is a synthetic growth hormone releasing hormone (GHRH). It stimulates the production and release of natural HGH, preserving these important feedback loops and acting with your body’s natural rhythms. Sermorelin is an ideal solution.

Sermorelin is classified as a synthetic growth hormone secretagogue. It is a peptide analogue of growth hormone-releasing hormone (GHRH). It only contains the first 29 amino acids (building blocks of protein) of GHRH but acts just like natural GHRH by stimulating the pituitary gland to produce and release more growth hormone.

Clinical trials have revealed that sermorelin promotes changes in growth hormone levels that are similar to those of endogenous (inside the body) GHRH. In multiple studies, sermorelin has been shown to increase growth hormone levels, resulting in increased strength and stamina and better sleep.

Participants in clinical trials had a measurable increase in lean body mass and a decrease in body fat, most notably metabolically active and therefore dangerous abdominal fat.

Cognitive testing showed that participants had an increase in fluid intelligence scores, especially in problem-solving, psychomotor speed processing, and working memory.

Growth hormone is released from the pituitary gland, travels through the bloodstream, binds to growth hormone receptors, or acts through its intermediary, insulin-like growth factor 1 (IGF-1).

In one study, participants treated with sermorelin for six months had a 35% increase in IGF-1 levels — impressive results that demonstrate how well this peptide works. Increases in IGF-1 are responsible for the changes in body composition expected from sermorelin use — increased muscle mass and bone density and decreased body fat. Study participants experienced a 5% to 8% average reduction in body fat.

Long-term usage studies are still being conducted, but the consensus is that sermorelin is especially well-tolerated and is an effective option for the purpose of anti-aging.