Slows the emptying of the stomach
Reduces cravings and the drive to eat
Vitamin B12 increases energy levels
Semaglutide, also marketed under the brand names Ozempic, Rybelsus and Wegovy, is an FDA-approved injectable for weight loss that mimics the actions of GLP-1, a hormone that targets specific areas of the brain known to suppress hunger. The ideal candidates for semaglutide are people with a BMI of 30 or greater or a BMI of 27 or greater and a medical condition made worse by obesity. Semaglutide is used in conjunction with a reduced-calorie diet and exercise.
Semaglutide has shown even more powerful effects than other medications in its class, potentially because of its increased dose. People who take semaglutide have altered food preferences, resulting in lower calorie consumption. In clinical trials, users lost an average of 35 pounds. Semaglutide is expected to work best for people who have trouble controlling their appetite and like to snack.
Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels. B12 is involved in regulating DNA coding for proteins (epigenetics) and many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition.
Semaglutide is a glucagon-like peptide 1 (GLP-1) agonist. GLP-1 is a hormone that binds to brain receptors that control hunger and appetite. Semaglutide causes weight loss by suppressing appetite. It decreases appetite by delaying stomach emptying and slowing intestinal motility, so you feel full longer. GLP-1 agonists also stimulate insulin secretion from the pancreas and reduce glucagon release—this lowers blood glucose. Insulin ushers glucose from the blood into the cells, where it can be used for energy.
Four clinical trials were conducted to examine the mechanism of action and safety of semaglutide. These trials evaluated the drug’s effects in people who were overweight or obese, with or without diabetes, and combined with mild or moderate behavioral interventions such as counseling about diet and exercise or meal replacements.
In the largest trial, the group that received semaglutide lost 12% more of their body weight at 68 weeks when compared to placebo. This was equivalent to an average weight loss of 35 pounds.
Semaglutide is a glucagon-like peptide 1 agonist that induces weight loss by controlling appetite. Losing excess weight can provide many health benefits by improving cardiovascular health, metabolic health, and restoring hormones, such as testosterone, to their baseline levels.
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Semaglutide helps people who are overweight or obese shed excess pounds. Semaglutide acts as an incretin mimetic, which means that it helps the pancreas release insulin when blood sugars are too high. It also slows stomach emptying and intestinal motility, so you feel full longer. In addition, Semaglutide helps people resist food cravings.
In a clinical trial, the group that received semaglutide lost 12% more of their body weight at 68 weeks when compared to placebo. This was equivalent to an average weight loss of 35 pounds. Overall, the medication was well-tolerated and effective.
Semaglutide is not right for everyone. People with the following conditions should not take semaglutide:
Tell your doctor if you have had:
Semaglutide has side effects, as do all medications. It is generally well-tolerated.
The most common side-effects reported in clinical trials are:
More serious side-effects include:
Semaglutide has two versions to treat type 2 diabetes: an FDA-approved injectable, brand name Ozempic and an oral pill, brand name Rezempic. Wegovy is an injectable form of semaglutide used to treat overweight or obesity.
Yes, a prescription is needed to get semaglutide. Generic semaglutide and brand names Ozempic, Rybelsus, and Wegovy all require prescriptions. Semaglutide is not right for everyone. A medical professional will evaluate your past medical history and risk factors for side effects before prescribing semaglutide.
Participants in clinical trials had stalled weight loss around week 60 and rebound weight gain. Therefore, it is important to make semaglutide part of a weight-maintenance plan, along with a low-calorie diet and a solid exercise plan. Develop good diet and exercise habits while taking semaglutide to make it easier to keep the weight off after you stop taking it.
Yes, prescription semaglutide is only one part of an effective weight management plan. Consuming a healthy diet and getting regular exercise are also very important for both weight loss and overall health.