Lessens the appearance of wrinkles and discolorations
Reduces sensitivity and damage from UV light exposure
Nicotinamide Adenine Dinucleotide (NAD+) is a universal cellular electron transporter, coenzyme, and signaling molecule found in all cells in the body. NAD+ is naturally produced in the body from the amino acid tryptophan or vitamin precursors. NAD+ levels are highest in newborns and gradually decline throughout life. By the age of 50, they are approximately one-half of those of a young adult.
NAD+, as an antioxidant, can protect skin cells from free radicals, which are unpaired electrons that cause skin damage, inflammation, and disease. Reducing damage from free electrons can extend the lifespan of healthy skin cells.
In one study, oral nicotinamide (a precursor of NAD+) reduced the number of nonmelanoma skin cancers by 23% when taken daily for 12 months. Participants had a history of at least two nonmelanoma skin cancers within the previous five years and thus, were considered high risk. Topical applications have a more direct effect on the skin without the side effects associated with oral preparations.
Clinical trials have demonstrated how NAD+ reduces inflammation in skin conditions such as rosacea and contact dermatitis. Patients reported a decrease in skin redness, swelling, and itching after applying NAD+ cream for three days. Papules and skin redness were markedly improved.
NAD+ can improve the inflammation associated with moderate acne and is less irritating to the skin than traditional acne preparations, such as clindamycin. Using an anti-inflammatory cream like NAD+ can alleviate concerns that topical antibiotics will lead to increased antibiotic resistance.
Ceramides are lipids that maintain the skin’s protective barrier. Ceramide levels are decreased in aging skin and in people with atopic dermatitis. A decrease in ceramides most likely causes the dryness and skin irritation you experience in the winter. In clinical studies, nicotinamide (a precursor to NAD+) boosted ceramide synthesis. Increased ceramides can plump skin cells and reduce fine lines and sagging.
NAD Face Cream
NAD+ is an essential component of the metabolic process in every cell in the body. It is a coenzyme that is involved in many anabolic processes, such as building complex proteins and fats. NAD+ picks up and drops off electrons. It shuttles electrons between metabolic processes in cells providing energy to build cellular tissue and repair DNA.
As NAD+ is converted to NADH and back again, some is lost and needs to be replaced. More is lost with aging, which jeopardizes cellular repair processes.
Besides its use in energy metabolism, NAD+ is a cofactor for NAD+ dependent enzymes such as Sirtuins (SIRTs) and poly (ADP-ribose) polymerases (PARP). Sirtuins and PARPs both play a role in the aging process. Over time, DNA, the genetic blueprint in every cell in the body, is damaged. DNA damage activates PARPs, which further deplete NAD+, a process that contributes to age-related disease.
Sirtuins (the longevity genes) are another class of NAD+ consuming molecules. These compounds protect DNA from damage. Sirtuins rely on NAD+ for energy. Without energy, they cannot function.
CD-38 also consumes NAD+. CD-38 levels rise with aging, sometimes by two to three times, requiring more NAD+. Without NAD+, DNA and cellular damage accumulate, and cells age and die.
Skin cells that are deficient in NAD+ are more vulnerable to the changes associated with aging. Boosting NAD+ provides energy for skin cells to repair cellular and DNA damage. Low NAD+ levels are associated with increased UV radiation sensitivity, decreased ability to repair DNA damage and an increased risk of skin cancer.
NAD+ depletion puts your skin at increased risk for non-melanoma skin cancer, DNA damage, and aging-related changes. Nourishing your skin cells with NAD+ cream supplies them with the energy they need to maintain a healthy cellular structure and protect themselves from UV radiation.
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NAD+ is an important coenzyme and signaling molecule that helps regulate energy produced in the mitochondria. When NAD+ levels decrease with aging, skin is more vulnerable to photo-damage from ultraviolet light. NAD+ can:
NAD+ can restore NAD+ levels in the skin. NAD+ is necessary to repair damage to the skin from ultraviolet radiation and environmental stressors that dry and irritate the skin. By applying NAD+ cream to the skin as directed, you can restore NAD+ levels and can expect to see less redness, irritation, wrinkles, age spots and areas of hyperpigmentation.
Vitamin B3 is a precursor for NAD. There are several ways your body can make NAD+. Vitamin B3 provides the raw materials your body needs to produce NAD+. However, many people experience significant side effects when taking vitamin B3. NAD+ cream directly supplies your skin with NAD+.
Foods that contain vitamin B3 (niacin) and nicotinamide mononucleotide are great dietary sources of NAD. Examples of foods high in NMN:
Examples of foods high in vitamin B3:
When researchers divided participants into four age groups:
They found a significant decrease in NAD+ levels in all adult populations. PARP activity was increased, as was DNA damage. There was no difference in SIRT1 between the age groups.
NAD levels decreased by an average of 50% between the adults and older adults leading researchers to conclude that though further research is needed, this study provides evidence supporting the need to maintain NAD+ levels for maintaining PARP activity (to repair DNA and other cellular processes).
No, these two molecules are not the same. NAC or N-acetyl cysteine comes from the amino acid L-cysteine. NAC is used in healthcare to treat acetaminophen poisoning, lung collapse, and when treating severe lung disease. In addition, your body uses NAC to produce glutathione, an important antioxidant.
NAD or nicotinamide adenine dinucleotide is involved in producing energy in the cell, maintaining cellular processes, and facilitating DNA repair.
Why NAD+ levels decline with age is an area of active research. NAD+ helps with repairing DNA and restoring optimal cellular processes. Animal studies show an association between NAD+ levels and lifespan. Theories on why NAD+ levels decline include:
Understanding why NAD+ levels decrease with age will help researchers better understand longevity and how to increase disease and disability-free lifespans.
No, NAD and NAD+ both refer to nicotinamide adenine dinucleotide, the important coenzyme and signaling molecule found in every cell in the body.