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Metformin Synergy

Metformin Synergy, prescribed by specialists, filled by an FDA-registered pharmacy

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Legitimate Pharmacies

Prescription Included

Licensed Physicians

Legitimate Pharmacies

Prescription Included

Purchase Metformin Synergy

Buying Metformin Synergy from Invigor Medical guarantees that you are working with a licensed, experienced, and dedicated doctor and receiving Metformin Synergy from a US-based, FDA 503B-registered pharmacy.

Enhances Glucose Metabolism	Better glucose utilization improves carbohydrate metabolism
Supports Weight Loss	Activates key pathways in the body that regulate glucose and fat metabolism in the liver

Single Purchase

$120

4 Weeks

Subscription

$110

Every 4 Weeks

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What is Metformin Synergy?

Metformin Lowers Blood Sugar And Facilitates Weight Loss

Metformin is in the class of medications called biguanides. Metformin helps control the amount of glucose in the blood and the amount released by the liver. It is used along with lifestyle modifications to lower blood sugar in people diagnosed with type 2 diabetes. It is considered a first-line treatment because it is effective, safe, and low-cost.

Metformin also facilitates weight loss. Proposed mechanisms of action for metformin’s weight loss effect include:

Decreasing liver glucose production
Altering gut microbiome
Suppressing appetite-stimulating brain cells in the hypothalamus
Increasing leptin sensitivity
Suppressing appetite by increasing lactate production
Reversing age-related metabolic changes
Altering bile absorption
Changing signaling in the gut

Leucine, Metformin and Sildenafil Synergistically Activate the SIRT 1 Pathway To Stimulate Weight Loss and Reduce Triglycerides

Leucine, metformin, and sildenafil synergistically work to reduce weight and triglycerides by activating SIRT1, according to a phase 2 clinical trial. Weight loss during the 16-week study period was linear, which suggests it will continue at the same rate. Activating Sirt1 is expected to support weight loss, improve cardiovascular function, and improve lipid metabolism.

Methylcobalamin or cyanocobalamin is a human-made form of vitamin B12. Vitamin B12 is a water-soluble vitamin naturally found in some foods and added to others. B12 supplements are available in both oral and injectable forms. B12 deficiency is fairly common, affecting 6% of people under age 60 and nearly 20% of those over age 60. Restoring B12 levels can help with weight-loss efforts.

What is Included?

MEDICAL CONSULTATION: Discuss your treatment plan with one of our licensed Practitioners.
MEDICATIONS / SUPPLEMENTS: All medications and supplies are included. No Hidden Fees.
KNOWLEDGEABLE STAFF: Our medical staff are well trained and ready to answer your questions.

Compounds in the Medication

Metformin	250mg	Learn More
Leucine	250mg	Learn More
Vitamin B12	20mcg	Learn More
Sildenafil	700mcg	Learn More

Included Supplies

Metformin Synergy Capsules Delivered Discreetly

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Signs You Might Need This Treatment Plan

Symptoms

You may be experiencing a combination of the following symptoms

Weight Gain
Fatigue
Mental Fog
Depressed Mood
Lack of Energy

If you are experiencing any of the symptoms listed above, please fill out our medical forms. After that, an Invigor Medical specialist will contact you.

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How Does Metformin Synergy Work?

Metformin is used to decrease blood glucose and fat deposition in the liver and to treat type 2 diabetes. Metformin decreases glucose production in the liver, decreases glucose absorption from the intestines, and improves insulin sensitivity. Metformin lowers blood glucose by about 25% to 30%, with a low risk for hypoglycemia. Metformin also improves the body’s response to insulin, a hormone that shuttles glucose from the bloodstream into cells.

Leucine, Metformin and Sildenafil Potentiate Metformin’s Weight Loss Potential

Researchers found that combining leucine, metformin and sildenafil worked better than metformin alone at activating the 5′ adenosine monophosphate-activated protein kinase (AMPK)/Sirtuin 1 (Sirt1) pathway, which regulates glucose and fat metabolism in the liver.

The combination also increases liver energy metabolism and decreases inflammation. Leucine is a direct Sirt 1 activator. Sildenafil inhibits phosphodiesterase 5 which increases nitric acid and increases blood flow. This pathway also interacts with the Sirtuin pathway, as it stimulates Sirt 1.

B12 Is Involved in Lipid Metabolism

Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels. B12 is involved in the regulation of DNA coding for proteins (epigenetics) as well as many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition.

Benefits of Metformin Synergy

The weight-loss potential for metformin has long been recognized and has been leveraged to treat type 2 diabetes. More recent clinical trials have demonstrated that sildenafil and leucine potentiate metformin’s weight loss potential. Together these medications work together on glucose metabolism through the AMPK/Sirt 1 pathways, important pathways involved in glucose and fat metabolism.

Promotes Weight Loss
Increases Energy
Boosts Metabolism
Improves Lipid Metabolism
Reduces Inflammation
Improves Glucose Utilization

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Included with the Plan

Free Doctor Consult

The consultation with the practitioner is always included when you buy Metformin Synergy.

Medical Support

Our friendly staff are knowledgeable and available to answer any questions.

Supplies Included

When you purchase Metformin Synergy, all required supplies are always included.

No Doctor’s Office

Skip the in person doctor’s visit and consult remotely, and get Metformin Synergy shipped direct.

Licensed Pharmacies

Our US based, FDA registered pharmacies provide quality meds tested for purity and potency.

Licensed Doctors

Our licensed doctors cover all 50 states and are very well versed with the medications we offer.

Related Treatment Plans

Treatment Plans related to Metformin Synergy for sale

Metformin Synergy FAQ’s

The Plan

What does metformin do in your body?

Metformin has been used for decades to manage blood sugar in type 2 diabetes. Metformin decreases the amount of glucose absorbed through your intestines and the amount produced in your liver. Metformin also improves your body’s sensitivity to insulin, making it easier for cells to transport glucose from the blood into cells where it can be used for energy.

What is the most serious side effect from metformin?

The most serious potential side-effect of metformin is lactic acidosis. Lactic acidosis can be life-threatening, so it is important to let your healthcare provider know if you have a history of kidney disease. Other risk factors for lactic acidosis include being over age 65 or having a history of:

Heart attack
Coma
Heart disease
Stroke

Some medications can also increase your risk of metabolic acidosis, so it’s important to tell your healthcare provider about every medication you are taking.

What are symptoms of metabolic acidosis?

Metabolic acidosis is a serious potential side-effect of metformin that may occur in some high-risk patients. Symptoms associated with lactic acidosis include:

Extreme tiredness
Weakness or pain
Nausea
Vomiting
Stomach pain
Decreased appetite
Rapid or deep breathing
Shortness of breath
Dizziness
Lightheadedness
Abnormally fast or slow heartbeat
Skin flushing
Muscle pain
Feeling cold, especially hands or feet

What should I avoid when taking metformin?

Let your healthcare provider and pharmacist know if you are taking any medications (over-the-counter or prescriptions) to ensure that any medications you are taking do not interact with metformin. Prescription medications that have the potential to increase lactic acid are a concern, including some anticancer, antimicrobial, and HIV medications.

Excess alcohol consumption is a risk factor for lactic acidosis, the most serious (though uncommon) potential side-effect of taking metformin. If you drink alcohol in excess, generally defined as more than one drink per day for women or two drinks per day for men, let your healthcare provider know.

Why are sildenafil and leucine used with metformin?

Researchers found that combining leucine, sildenafil, and metformin worked better than metformin alone at activating the SIRT 1 pathway. The SIRT 1 pathway is a key pathway that regulates glucose and fat metabolism in the liver. Leucine directly stimulates the SIRT1 pathway, and sildenafil increases nitric oxide, which increases blood flow.

What is the average weight loss with metformin?

Weight loss from metformin alone is a gradual process. The average weight loss is 5 to 6 pounds. This is why metformin is combined with leucine, vitamin B12, and sildenafil. It is also important to consume a healthy diet and engage in physical activity. Metformin synergy supports your weight loss efforts.

Does metformin cause nausea and upset stomach?

Yes, metformin can cause nausea and upset stomach. However, for most people, these symptoms improve within two weeks. It is important to let your healthcare provider know about any symptoms you may be experiencing.

Isn’t sildenafil used for erectile dysfunction?

Yes, sildenafil (Viagra, Revatio) is used to treat erectile dysfunction. Sildenafil is a type of phosphodiesterase inhibitor. By inhibiting the breakdown of phosphodiesterase, nitric acid is active longer. Nitric oxide relaxes smooth muscle and dilates blood vessels which increases blood flow. In addition, sildenafil was found to help metformin activate the SIRT 1 pathway.

Invigor Medical

Do I need a prescription before I buy from Invigor Medical?

No, Invigor Medical employs doctors licensed in all 50 states, and a medical consultation is included with each medical service. Each patient will recieve a valid prescription which is sent to the pharmacy to be filled.

How long does it take to get my medication?

Once you have enrolled for medical services with Invigor Medical, it usually takes 3-7 work days before items arive at your home. This process includes an online medical consult, prescription approval, the medication getting filled at the pharmacy, and the medication sent to your home.

How do I know if I will be approved?

Most of the services that Invigor Medical offers are elective services. This means that most clients, if there are no restrictive contraindications, will be approved for the medications of their choice.

More Questions?

Fill out the form below, and one of our treatment specialists will contact you.

Metformin Synergy Reviews

References

Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus. The Multicenter Metformin Study Group

https://pubmed.ncbi.nlm.nih.gov/7623902/
Randomised Clinical Trial: A Leucine-Metformin-Sildenafil Combination (NS-0200) Vs Placebo In Patients With Non-Alcoholic Fatty Liver Disease

https://onlinelibrary.wiley.com/doi/10.1111/apt.14674
Metformin: Mechanisms in Human Obesity and Weight Loss

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520185/#R15
Long-Term Safety, Tolerability, and Weight Loss Associated with Metformin in the Diabetes Prevention Program Outcomes Study.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308305/
Investigating the Synergistic effect of Leucine-Metformin-Sildenafil on Nonalcoholic Steatohepatitis

https://scholarworks.gsu.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1069&context=biology_theses
Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial

https://pubmed.ncbi.nlm.nih.gov/33369909/
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

https://pubmed.ncbi.nlm.nih.gov/30569637/
Vitamin B12

https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
Vitamin B12 and Health

https://www.cfp.ca/content/cfp/54/4/536.full.pdf
The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity

https://clinicaltrials.gov/ct2/show/NCT03364335
Metformin (Medline Plus)

https://medlineplus.gov/druginfo/meds/a696005.html
Effectiveness of Metformin on Weight Loss in Non-Diabetic Individuals with Obesity

https://doi.org/10.1055/s-0032-1327734
Role of Metformin in Overweight and Obese People Without Diabetes: A Systematic Review and Network Meta-Analysis

https://link.springer.com/article/10.1007/s00228-018-2593-3?shared-article-renderer

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