Civance is a nootropic that provides your brain with the energy and compounds it needs to keep its synapses firing all day long. Citicoline, acetyl-L-carnitine, and huperzine A support acetylcholine production, a neurotransmitter associated with increased alertness, attention, learning, and memory.

Citicoline is a brain-protective supplement that increases choline and cytidine stores in the body. Choline is a precursor to acetylcholine, a neurotransmitter in the brain associated with alertness, attention, learning, and memory. With aging, choline levels decline. Brain cells break down cell membranes to source choline in order to restore acetylcholine levels.

Blueberry extract is high in polyphenols, antioxidants, and anthocyanin, all of which boost cognitive function and protect the nervous system from oxidative damage. Blueberries have been shown to help prevent cancer, obesity, inflammation, heart disease, liver disease, and declines in cognitive function.

Huperzine A has been used for centuries in traditional Chinese medicine to treat inflammation, swelling, pain, and memory loss. A meta-analysis of 20 huperzine A clinical trials have indicated that huperzine A has potential cognitive benefits. Clinical trials are underway to evaluate huperzine A’s effectiveness as a potential treatment for Alzheimer’s disease.

Acetyl-L carnitine is a building block of protein that is used to treat a variety of cognitive diseases, including Alzheimer’s disease, age-related memory loss, and late-life depression. It is also prescribed to treat fatigue related to chronic disease and used to treat symptoms associated with decreased testosterone levels.

Together these compounds enhance cognitive performance while protecting the brain from inflammation and damage from the byproducts of metabolism.

Citicoline is used to synthesize acetylcholine, norepinephrine, and dopamine in the brain. These chemical messengers are associated with learning, attention, and mood. Citicoline also increases glutathione production and opposes metabolic processes that promote cell death.

L-carnitine is converted into acetyl-L-carnitine by the enzyme carnitine acetyltransferase (ALCAR). Higher levels of acetyl-L-carnitine (ALCAR) increase acetylcholine, GABA, and glutamate in the brain. As brain cells age, inflammation increases and neurons become less functional. ALCAR is thought to support acetylcholine levels — enhancing memory and attention and improving focus. ALCAR also helps the body produce energy that can be used for muscle movement, brain functions, and much more.

Huperzine A is an extract from the Chinese club moss Huperzia serrata. It is a selective acetylcholinesterase inhibitor that increases acetylcholine levels in the brain, supporting attention and memory. Huperzine A also has antioxidant and neuroprotective properties. It counteracts glutamate-induced toxicity and subsequent damage to brain cells, possibly by interacting with NMDA receptors.

Citicoline is an intermediate in the production of phospholipids. Phospholipids are found in the cell membranes of all cells in the body but are especially important for brain cells. Phosphatidylcholine, a component of cell membranes, makes up about 30% of the gray matter in the brain. Gray matter is directly responsible for memory, attention, emotion, speech, hearing, seeing, and brain processing. Stabilizing the cell membranes in brain cells helps protect them from damage and loss of function.

Anthocyanins, which are colorful pigments found in the phenolic group, are abundant in blueberries. Blueberry extract is rich in polyphenols, which have potent antioxidant effects. Several clinical trials have been conducted to assess the potential of blueberry extract to improve memory in older adults. Through the brain-derived neurotrophic signaling pathway, blueberries lower oxidative stress in the brain and increase brain function.

Aside from providing cognitive support, foods high in antioxidants, such as blueberries, lower the risk of heart disease, diabetes, obesity, and other inflammatory conditions.