Bella+ is a combination of several drugs that independently have shown tremendous promise in supporting weight loss. These medications act on the hypothalamus of the brain to reduce cravings and suppress hunger, making it easier for you to control your appetite.

Naltrexone is an opioid receptor agonist, and bupropion is a dopamine and norepinephrine reuptake inhibitor. This combination has been prescribed for years to enhance weight management efforts in overweight or obese adults. Together these two medications activate a part of the brain that controls hunger.

Animal studies have revealed that oxytocin reduces the desire for food intake, increases energy expenditure, and increases fat breakdown. In people, it decreases cravings for high-calorie foods and increases satiety. Studies show that oxytocin levels decrease with age.

Oxytocin is also integral to the stress response. It dampens the brain’s response to stress, reducing anxiety.

Researchers discovered that restoring oxytocin levels also boosted the activity of muscle stem cells, potentially increasing calorie-burning muscle cells.

Metformin is a prescription medication used to treat type 2 diabetes. Several large-scale studies have shown its effectiveness in weight loss, by regulating hunger in the brain, reversing changes associated with aging, or altering the microbiome in the gut.

Weight loss was a noted side effect when topiramate is used to treat seizures.

Vitamin B12 has been linked to weight loss, and deficiencies may increase the risk of obesity. Several studies have found a link between low vitamin B12 levels and type 2 diabetes, high blood pressure, obesity, and metabolic syndrome.

Bella+ combines these well-studied compounds that synergistically work in the brain to control your cravings and modulate your appetite while also improving sleep quality, decreasing anxiety, and improving a sense of social connection.

Bella is made up of six drugs, each of which is known for its potential to support weight loss. Bupropion is a norepinephrine reuptake inhibitor, and naltrexone is an opioid receptor antagonist. Bupropion and naltrexone work together in the hypothalamus to reduce cravings and hunger. They activate POMC neurons in the hypothalamus, a brain region that produces a neurotransmitter that reduces appetite. Naltrexone also blocks a feedback loop that attempts to down-regulate POMC neurons.

A reward center in the brain called the mesolimbic system is stimulated by pleasurable activities such as eating or even thinking about eating. Bupropion and naltrexone can regulate these feelings of pleasure, reducing cravings to eat.

Oxytocin is a nine-amino acid peptide hormone made in the hypothalamus. In animal studies, oxytocin administration resulted in sustained weight loss by reducing food intake, boosting energy expenditure, and promoting fat breakdown. Oxytocin may also impact blood sugar control, a benefit independent of weight loss.

When oxytocin nasal spray was tested in humans, it produced similar results, including weight loss, decreased caloric intake, increased fat breakdown, and improved insulin sensitivity.

Topiramate is an anti-seizure medication used to treat epilepsy and migraines that has weight loss as a known side effect. When tested in clinical trials, topiramate induced weight loss and improved blood sugar control in adults with type 2 diabetes and obesity. Some users reported that topiramate altered their sense of taste, which may also help with appetite control.

Metformin is a prescription medication used to control blood sugar in people with type 2 diabetes. Large studies have also demonstrated its weight loss potential. Metformin works by modulating appetite control centers in the hypothalamus, minimizing age-related decreases in muscle mass and metabolic changes, and altering the gut microbiome.

Vitamin B12 is a water-soluble vitamin that is involved in forming DNA and red blood cells. It may also help fight fatigue, boost energy, and support weight loss efforts. Research on how vitamin B12 affects metabolism is very limited. However, in a study that enrolled over 9,000 people, having high levels of B12 was associated with a lower risk of obesity.