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 9 Common Questions About Sermorelin for Women

Jun 21, 2023
 9 Common Questions About Sermorelin for Women

Many men choose Sermorelin for its ability to stimulate the release of growth hormone (GH) from the pituitary gland. GH release declines starting around age 30, and this decline is associated with many of the changes we see with aging, such as a decline in muscle mass and strength, decreased bone density, increased fat accumulation, declines in cardiovascular health, and prolonged recovery times after exercise. This brings up several questions about Sermorelin for women. Does Sermorelin offer the same benefits for women?

How fast do growth hormone levels decline in women?

While the studies looked at men, not women, the results should be comparable. GH production is thought to decrease by about 14% each decade and may decline by up to 50% every seven years in adult men.2 Circulating levels of insulin growth factor-1 (IGF-1) also decline with aging, but the decline is less steep.3

Does Sermorelin give you muscles?

Taking Sermorelin does not give you muscles. It is a secretagogue that acts like a growth hormone-releasing hormone by stimulating the natural release of growth hormone. Unfortunately, there is not much research on Sermorelin and women. Instead, most research focuses on growth hormone injections in men. Growth hormone injections in older men increased lean body mass, including muscle mass, increased bone density and skin thickness, and decreased fat mass.3

Two women lifting weights

Is there any research on the effect of growth hormone on women?

In one study, women aged 65 to 88 were given growth hormone with or without sex steroids over 26 weeks to evaluate their effect on muscle strength and endurance.

Lean body mass in women

  • Increased by 0.4 kg in the placebo group
  • Increased by 1.2 kg in the sex steroid hormone replacement group
  • Increased by 1.0 kg in the GH group
  • Increased by 2.1 kg in the GH and sex steroid hormone replacement group

Fat mass decreased significantly in women who received growth hormone or growth hormone plus sex steroids. Women’s strength increased, but the results were not significant.4  More research is needed because these studies are conducted using growth hormone, not Sermorelin, and the results may vary.

Can Sermorelin give me better skin?

There is not a lot of research on the effects of growth hormone secretagogues on skin texture and thickness because most growth hormone research has focused on changes in body composition. Stimulating natural growth hormone release is expected to increase collagen production and skin cell growth. Since growth hormone is an anabolic hormone, it increases skin cell size, growth, and cellular differentiation. Growth hormone stimulates the release of growth factors that can increase collagen production, skin density, mechanical strength, and skin thickness. Sermorelin is expected to help your skin maintain a more youthful appearance.

 9 Common Questions About Sermorelin for Women

Can you take too much Sermorelin?

Yes, all medications have side effects, and the risk of side effects can increase with increased dosage. Since Sermorelin stimulates natural growth hormone and growth hormone is regulated by feedback loops, it is difficult to overdose on Sermorelin.

Sermorelin is much safer than injecting growth hormone because it works with your body’s natural cycles. Injecting growth hormone directly will suppress your body’s release of growth hormone. Side effects associated with too much growth hormone include joint pain, swelling, carpal tunnel syndrome, and increased risk of metabolic syndrome, diabetes, and cancer. Injecting growth hormone to treat the effects of aging is illegal in the United States.3

How much weight can I lose by taking Sermorelin?

Once again, the studies are in men taking growth hormone, not women taking Sermorelin. In this study, 52 healthy men over age 69 took growth hormone or a placebo three times weekly for six months. By the end of the study, the men taking growth hormone had an average increase in lean body mass of 4.3% and a decrease in fat mass of 13%.5 The effects of Sermorelin on weight loss are not likely comparable to a weight management plan focusing on a low-calorie diet and daily exercise. But Sermorelin can support your weight loss efforts, making them more effective.

Can pregnant women take Sermorelin?

No, pregnant women should not take Sermorelin. It is not considered a safe medication to take during pregnancy. People who are pregnant, breastfeeding, or have low thyroid function should not take Sermorelin.

How quickly does Sermorelin work?

Because Sermorelin stimulates the release of growth hormone from the pituitary gland and does not replace growth hormone, it can take 4 to 6 months or more to see the full effects of Sermorelin.

A female doctor talking with a patient

When should I take Sermorelin?

Since Sermorelin stimulates growth hormone release and the biggest pulses of growth hormone are released right before sleep, take Sermorelin before retiring for the night.6

Free fatty acids and changes in blood sugar levels can affect growth hormone release. Taking Sermorelin on an empty stomach helps ensure that you receive the full benefit of the medication. Take Sermorelin before bedtime and resume normal mealtimes the next day for best results.

Sermorelin stimulates the natural release of growth hormone and is a safer alternative than the off-label use of growth hormone injections.7 Much of the research on growth hormone has been conducted on men, but the results are likely to be comparable in women. If you have questions about whether Sermorelin is a good choice for you, contact one of the treatment specialists at Invigor Medical.

Buy Sermorelin injections online.


While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 

Buy Sermorelin injections online.


1. Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev. 1998 Dec;19(6):717-97. doi: 10.1210/edrv.19.6.0353. PMID: 9861545.

2. Sattler FR. Growth hormone in the aging male. Best Pract Res Clin Endocrinol Metab. 2013 Aug;27(4):541-55. doi: 10.1016/j.beem.2013.05.003. Epub 2013 Jun 18. PMID: 24054930; PMCID: PMC3940699.

3. Bartke A. Growth Hormone and Aging: Updated Review. World J Mens Health. 2019 Jan;37(1):19-30. doi: 10.5534/wjmh.180018. Epub 2018 May 11. PMID: 29756419; PMCID: PMC6305861.

4. Blackman MR, Sorkin JD, Münzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O’Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2282-92. doi: 10.1001/jama.288.18.2282. PMID: 12425705.

5. Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, Grunfeld C. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med. 1996 Apr 15;124(8):708-16. doi: 10.7326/0003-4819-124-8-199604150-00002. PMID: 8633830.

6. Salvatori R. Growth hormone and IGF-1. Rev Endocr Metab Disord. 2004 Mar;5(1):15-23. doi: 10.1023/B:REMD.0000016121.58762.6d. PMID: 14966386.

7. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

 9 Common Questions About Sermorelin for Women

Leann Poston, M.D.

Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.


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