Skip to main content
Trimix
Trimix
Trimix is a highly effective formulation comprised of three medications — phentolamine, papaverine, and alprostadil — that work synergistically with a 95% success rate. All three medications increase blood flow into the penis, helping men get and sustain an erection. You can buy this medication from Invigor Medical with an included medical consultation.
Get Trimix Injections from Invigor Medical
Category
For Use By
Delivery Method

Can I Buy Trimix?


Patients of Invigor Medical can buy Trimix, prescribed by specialists and filled by an FDA-registered pharmacy.


Do we offer Trimix as part of a treatment plan?
Yes
High Success Rate
80-95% success rate
Works Fast
Works within minutes

How Does Trimix Work?

The Synergistic Trio for Enhanced Blood Flow

Three medications work synergistically in Trimix: Papaverine increases cyclic adenosine monophosphate (cAMP) production, which relaxes the smooth muscle in the walls of blood vessels. Its mechanism is not completely understood because it works on many pathways. Ultimately, it increases blood flow into the penis and inhibits outflow resulting in an erection. Phentolamine is an alpha-adrenoceptor antagonist that relaxes and dilates blood vessels entering the penis, thereby increasing blood flow. Alprostadil is a synthetic version of prostaglandin E1. It also dilates blood vessels and increases blood flow into the penis.

The Integrated Mechanism of Trimix Components

The combined action of Trimix’s three key ingredients—Papaverine, Phentolamine, and Alprostadil—creates a highly effective treatment for erectile dysfunction. While each component individually contributes to increasing blood flow into the penis, their synergistic effect results in a more potent and sustained erection.

Papaverine’s role in enhancing cAMP production, Phentolamine’s ability to relax and dilate blood vessels, and Alprostadil’s effectiveness in vascular dilation, all converge to effectively counteract erectile dysfunction. This integrated mechanism allows this medication for ED to provide a reliable solution for those seeking improved sexual performance, highlighting its distinct advantage in the management of erectile dysfunction.

Benefits of Trimix


Intracavernosal injections are a safe erectile dysfunction treatment option for a diverse group of men, including men with diabetes and cardiovascular disease.
  • Trimix
    Very effective combination of medications to treat erectile dysfunction
  • Trimix
    80-95% effectiveness

Want us to contact you?

Submit your info and we will contact you

Drug Details

Indications

What is Trimix used for?

  • Erectile dysfunction

Contraindications

You should avoid Trimix if you are/have:

As with all medications for ED, you should not use Trimix if you have ever been told by a healthcare provider that your heart is not healthy enough for sexual activity. This ED medication should not be taken with any oral ED medications.

Trimix and oral ED medications: Do not take sildenafil, vardenafil, or avanafil within 18 hours (before or after) an injection. Do not inject within 72 hours of taking tadalafil 10 mg or 20 mg.

Before using this medication, advise your healthcare provider if you:
  • Have a hypersensitivity or an allergy to any component in the formulation.
  • Have a condition that predisposes you to priapism (a painful erection lasting over four hours)
  • Have sickle cell anemia, multiple myeloma, or leukemia
  • Have an anatomical deformity of the penis
  • Are taking any medications that interfere with blood clotting
  • Are taking any medications, herbs, nonprescription drugs, or supplements, especially medications for high blood pressure, medications for depression, or those classified as MAO inhibitors such as phenelzine or a sleep aid such as trazadone.
Trimix Side Effects

What are the side effects of Trimix?

Potential side effects of this medication include the following:
Common Trimix Side Effects
  • Priapism is an erection that has lasted more than four hours. Untreated priapism can damage the structure of the penis.
  • Bruising at the injection site may occur depending on injection frequency and technique.
  • Fibrosis or scarring of the penis may occur, though the risk is thought to be very small.
  • Pain or redness at the injection site
  • Lumps, swelling, tenderness, or curvature of the erect penis may occur and are largely dependent on the injection technique.
Rare Trimix Side Effects
  • Diarrhea
  • Nausea
  • Stomach cramps or vomiting
  • An allergic reaction
  • A sudden decrease in blood pressure
  • Increased heart rate or abnormal heart rhythm

Trimix Dosage Information

Trimix Dosage & Frequency

Typical Trimix Dosage & Frequency
  • 0.1 - 0.5mL injection
  • 20-30 Minutes Before Sex

References

  • IMPROVING QUALITY OF LIFE
    https://www.suna.org/sites/default/files/download/members/unjarticles/2006/06dec/449.pdf
  • A Three-Drug Injection Used to Treat Erectile Dysfunction
    https://search.proquest.com/openview/c9c95ac19b1799ba6eb18042c7d52736/1?pq-origsite=gscholar&cbl=32986
  • Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction
    https://www.nature.com/articles/3900585.pdf?origin=ppub
  • ERECTILE DYSFUNCTION
    https://healthcare.utah.edu/menshealth/conditions/erectile-dysfunction/trimix-injection.php
  • Erectile dysfunction: a global review of intracavernosal injectables
    https://pubmed.ncbi.nlm.nih.gov/30895359/
  • Penile Injection Therapy
    https://www.mskcc.org/cancer-care/patient-education/penile-injection-therapy
  • Penile Injections
    https://www.empowerpharmacy.com/drugs/trimix-injection
  • About Penile Injection Therapy
    https://www.mskcc.org/cancer-care/patient-education/penile-injection-therapy

Related Articles

Some articles that might shed some light on this treatment plan
Trimix Dosage: How Many Units Of Trimix Should I Take?

Trimix Dosage: How Many Units Of Trimix Should I Take?

June 20, 2020
The erectile dysfunction medication Trimix has been shown, time and time again, to be an effective remedy for men who haven’t had success with oral ED treatments.  It is available by prescrip...
How And Where To Get Trimix

How And Where To Get Trimix

March 5, 2020
It seems like you can’t go anywhere online today without seeing some kind of advertising for erectile dysfunction treatments.  Generic versions of most major oral ED medications are now avail...
Everything You Need To Know About Trimix Injections

Everything You Need To Know About Trimix Injections

September 22, 2019
This article will serve as a guide to frequently asked questions about Trimix injections. It will cover basic information such as what Trimix is and what it is used to treat for curious but casual...