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Trimix is a highly effective formulation comprised of three medications — phentolamine, papaverine, and alprostadil — that work synergistically with a 95% success rate. All three medications increase blood flow into the penis, helping men get and sustain an erection. You can buy this medication from Invigor Medical with an included medical consultation.
Get Trimix Injections from Invigor Medical
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Can I Buy Trimix?

Patients of Invigor Medical can buy Trimix, prescribed by specialists and filled by an FDA-registered pharmacy.

Do we offer Trimix as part of a treatment plan?
High Success Rate
80-95% success rate
Works Fast
Works within minutes

How Does Trimix Work?

The Synergistic Trio for Enhanced Blood Flow

Three medications work synergistically in Trimix: Papaverine increases cyclic adenosine monophosphate (cAMP) production, which relaxes the smooth muscle in the walls of blood vessels. Its mechanism is not completely understood because it works on many pathways. Ultimately, it increases blood flow into the penis and inhibits outflow resulting in an erection. Phentolamine is an alpha-adrenoceptor antagonist that relaxes and dilates blood vessels entering the penis, thereby increasing blood flow. Alprostadil is a synthetic version of prostaglandin E1. It also dilates blood vessels and increases blood flow into the penis.

The Integrated Mechanism of Trimix Components

The combined action of Trimix’s three key ingredients—Papaverine, Phentolamine, and Alprostadil—creates a highly effective treatment for erectile dysfunction. While each component individually contributes to increasing blood flow into the penis, their synergistic effect results in a more potent and sustained erection.

Papaverine’s role in enhancing cAMP production, Phentolamine’s ability to relax and dilate blood vessels, and Alprostadil’s effectiveness in vascular dilation, all converge to effectively counteract erectile dysfunction. This integrated mechanism allows this medication for ED to provide a reliable solution for those seeking improved sexual performance, highlighting its distinct advantage in the management of erectile dysfunction.

Benefits of Trimix

Intracavernosal injections are a safe erectile dysfunction treatment option for a diverse group of men, including men with diabetes and cardiovascular disease.
  • Trimix
    Very effective combination of medications to treat erectile dysfunction
  • Trimix
    80-95% effectiveness

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Drug Details


What is Trimix used for?

  • Erectile dysfunction


You should avoid Trimix if you are/have:

As with all medications for ED, you should not use Trimix if you have ever been told by a healthcare provider that your heart is not healthy enough for sexual activity. This ED medication should not be taken with any oral ED medications.

Trimix and oral ED medications: Do not take sildenafil, vardenafil, or avanafil within 18 hours (before or after) an injection. Do not inject within 72 hours of taking tadalafil 10 mg or 20 mg.

Before using this medication, advise your healthcare provider if you:
  • Have a hypersensitivity or an allergy to any component in the formulation.
  • Have a condition that predisposes you to priapism (a painful erection lasting over four hours)
  • Have sickle cell anemia, multiple myeloma, or leukemia
  • Have an anatomical deformity of the penis
  • Are taking any medications that interfere with blood clotting
  • Are taking any medications, herbs, nonprescription drugs, or supplements, especially medications for high blood pressure, medications for depression, or those classified as MAO inhibitors such as phenelzine or a sleep aid such as trazadone.
Trimix Side Effects

What are the side effects of Trimix?

Potential side effects of this medication include the following:
Common Trimix Side Effects
  • Priapism is an erection that has lasted more than four hours. Untreated priapism can damage the structure of the penis.
  • Bruising at the injection site may occur depending on injection frequency and technique.
  • Fibrosis or scarring of the penis may occur, though the risk is thought to be very small.
  • Pain or redness at the injection site
  • Lumps, swelling, tenderness, or curvature of the erect penis may occur and are largely dependent on the injection technique.
Rare Trimix Side Effects
  • Diarrhea
  • Nausea
  • Stomach cramps or vomiting
  • An allergic reaction
  • A sudden decrease in blood pressure
  • Increased heart rate or abnormal heart rhythm

Trimix Dosage Information

Trimix Dosage & Frequency

Typical Trimix Dosage & Frequency
  • 0.1 - 0.5mL injection
  • 20-30 Minutes Before Sex


  • A Three-Drug Injection Used to Treat Erectile Dysfunction
  • Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction
  • Erectile dysfunction: a global review of intracavernosal injectables
  • Penile Injection Therapy
  • Penile Injections
  • About Penile Injection Therapy

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