Tadalafil and phentolamine act by different mechanisms to synergistically increase blood flow into the penis, producing an erection.

Can I Buy Tadalafil/Phentolamine Online?

Patients can Buy Tadalafil/Phentolamine with an included consultation with a doctor.
FDA Designation
For Use By
Delivery Method
Included Compounds

Can I Buy Tadalafil/Phentolamine?

You can buy Tadalafil/Phentolamine with the included prescription consultation. After consulting with the doctor via an online Telehealth visit the medication is sent directly from the pharmacy.

Do we offer Tadalafil/Phentolamine as part of a treatment plan?
Treats ED
Proven to treat erectile dysfunction

How Does Tadalafil/Phentolamine Work?

Increase nitric oxide levels

Tadalafil is a selective phosphodiesterase (PDE) type 5 inhibitor, increasing nitric oxide levels after sexual stimulation. Increased nitric oxide levels facilitate smooth muscle relaxation in the penis, allowing blood to fill the corpus cavernosum in the penis, producing an erection.

Increase Blood Flow

Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa. It is typically used with papaverine to treat ED. Clinical studies show that phentolamine, combined with papaverine, dilates blood vessels entering the penis, with an erection occurring within 20 to 30 minutes.

Benefits of Tadalafil/Phentolamine

Some details about the benefits of this medication.
  • Treat Erectile Dysfunction

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Start by Selecting a Treatment Plan

Drug Details


What is Tadalafil/Phentolamine used for?

  • Tadalafil and phentolamine are both medically indicated to treat erectile dysfunction.


When should you avoid Tadalafil/Phentolamine?

  • Hypersensitivity or Allergy to the Medications
  • Bleeding disorders
  • Eye or vision problems
  • Peyronie’s disease
  • History of priapism
  • Heart disease
  • Stomach ulcers
  • Kidney disease
  • Liver disease
  • Stroke
Tadalafil/Phentolamine Side Effects

What are the side effects of Tadalafil/Phentolamine?

Tadalafil and phentolamine together are listed as a moderate drug interaction. Some side effects may include:
Common Tadalafil/Phentolamine Side Effects
  • Low blood pressure
  • Risk of dizziness
  • Lightheadedness
  • Fainting
  • Flushing
  • Headache
  • Nasal congestion
  • Nausea
Rare Tadalafil/Phentolamine Side Effects
  • Blurred vision
  • Chest pain
  • An erection that is painful or lasts longer than 4 hours (priapism)


  • Guidelines on Male Sexual Dysfunction: Erectile dysfunction and premature ejaculation
  • Long-term safety and efficacy of oral phentolamine
  • Tadalafil (Rx)
  • Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence
  • Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study
  • Phentolamine

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