Tadalafil/Phentolamine

Tadalafil and phentolamine act by different mechanisms to synergistically increase blood flow into the penis, producing an erection.

Can I Buy Tadalafil/Phentolamine Online?

Patients can Buy Tadalafil/Phentolamine with an included consultation with a doctor.

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FDA Designation

Can I Buy Tadalafil/Phentolamine?

You can buy Tadalafil/Phentolamine with the included prescription consultation. After consulting with the doctor via an online Telehealth visit the medication is sent directly from the pharmacy.

Do we offer Tadalafil/Phentolamine as part of a treatment plan?

Yes

Treats ED

Proven to treat erectile dysfunction

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How Does Tadalafil/Phentolamine Work?

Increase nitric oxide levels

Tadalafil is a selective phosphodiesterase (PDE) type 5 inhibitor, increasing nitric oxide levels after sexual stimulation. Increased nitric oxide levels facilitate smooth muscle relaxation in the penis, allowing blood to fill the corpus cavernosum in the penis, producing an erection.

Increase Blood Flow

Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa. It is typically used with papaverine to treat ED. Clinical studies show that phentolamine, combined with papaverine, dilates blood vessels entering the penis, with an erection occurring within 20 to 30 minutes.

Benefits of Tadalafil/Phentolamine

Some details about the benefits of this medication.

Treat Erectile Dysfunction

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Tadalafil/Phentolamine Treatment Plan

Erectile Dysfunction

Drug Details

Indications

What is Tadalafil/Phentolamine used for?

Tadalafil and phentolamine are both medically indicated to treat erectile dysfunction.

Contraindications

When should you avoid Tadalafil/Phentolamine?

Hypersensitivity or Allergy to the Medications
Bleeding disorders
Eye or vision problems
Peyronie’s disease
History of priapism
Heart disease
Stomach ulcers
Kidney disease
Liver disease
Stroke

Tadalafil/Phentolamine Side Effects

What are the side effects of Tadalafil/Phentolamine?

Tadalafil and phentolamine together are listed as a moderate drug interaction. Some side effects may include:

Common Tadalafil/Phentolamine Side Effects

Low blood pressure
Risk of dizziness
Lightheadedness
Fainting
Flushing
Headache
Nasal congestion
Nausea

Rare Tadalafil/Phentolamine Side Effects

Blurred vision
Chest pain
An erection that is painful or lasts longer than 4 hours (priapism)

References

Guidelines on Male Sexual Dysfunction: Erectile dysfunction and premature ejaculation
https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.665.1158&rep=rep1&type=pdf
Long-term safety and efficacy of oral phentolamine
https://www.nature.com/articles/3900885
Tadalafil (Rx)
https://reference.medscape.com/drug/adcirca-cialis-tadalafil-342873#0
Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699638/#:~:text=Forty%20seven%20percent%20of%20the,the%20time%20interval%20post%2Ddosing.
Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study
https://pubmed.ncbi.nlm.nih.gov/17233779/
Phentolamine
https://go.drugbank.com/drugs/DB00692

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