Metformin

Metformin is used to manage blood sugar levels in people with type 2 diabetes. It is used off-label to induce weight loss, especially in high-risk individuals. Studies show that metformin may also cause weight loss by modulating appetite control centers in the hypothalamus and altering the gut microbiome.

Can I Buy Metformin from Invigor Medical?

Patients can purchase Metformin with an included prescription consultation with a doctor.

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Clinical Formula

C₄H₁₁N₅

FDA Designation

Biguanides

Other Names

Glucophage, Riomet, Fortamet, Glumetza

Can I Buy Metformin?

Approved patients can buy Metformin (generic glucophage) with the included prescription consultation. After consulting with the doctor via an online Telewellness visit, and after the patient is approved, the medication is sent directly from the pharmacy.

Do we offer Metformin as part of a treatment plan?

Yes

Insulin Sensitivity	Increase Insulin Sensitivity
Decrease Appetite	Metformin can help decrease appetite and cravings

View Treatment Options

How Does Metformin Work?

Metformin Can Support Weight Loss

Metformin decreases glucose production in the liver, decreases glucose absorption from the intestines, and improves insulin sensitivity. Metformin lowers blood glucose by about 25% to 30%, with a low risk for hypoglycemia. Proposed mechanisms of action for metformin that may support weight loss include:

Decrease in liver glucose production
Alter gut microbiome
Suppress appetite-stimulating brain cells in the hypothalamus
Increase leptin sensitivity
Appetite suppression by increasing lactate production
Reversal of age-related metabolic changes
Alter bile absorption
Changes signaling in the gut

Benefits of Metformin

Metformin has the following potential benefits:

Decrease blood glucose levels and glucose production in the liver
Support weight loss

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Where do I Start?

Start by Selecting a Treatment Plan

Metformin Treatment Plan

Anti-Aging, Energy, Weight Loss

Drug Details

Indications

What is Metformin used for?

Metformin is medically indicated to treat type 2 Diabetes Mellitus.
Metformin is also used off-label to treat polycystic ovary syndrome.

Contraindications

When should you avoid Metformin?

Allergy or hypersensitivity to the medication or its ingredients
Severe renal impairment
Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
Type 1 diabetes mellitus
Use with caution in those who:
Have kidney disease
High ketone levels in the blood or urine
Congestive heart failure
Liver disease
Use insulin
Anemia
Have high alcohol consumption
Become easily dehydrated
Have a history of a heart attack

Metformin Side Effects

What are the side effects of Metformin?

Potential side effects from metformin include:

Common Metformin Side Effects

diarrhea
bloating
stomach pain
gas
indigestion
constipation
unpleasant metallic taste in mouth
heartburn
headache
flushing of the skin
nail changes
muscle pain

Rare Metformin Side Effects

More serious side-effects include chest pain and allergic reactions. Severe lactic acidosis may develop with symptoms such as muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, weak or tired.

Metformin Dosage Information

Metformin Dosage & Frequency

Typical Metformin Dosage & Frequency

500-1000mg
Daily

References

Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes
American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35(suppl1):S11-S63.
American Diabetes Association. Standards of medical care in diabetes-2014. Diabetes Care 2014;37(suppl1):S14-S80.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520185/
https://pubmed.ncbi.nlm.nih.gov/7623902/

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