Metformin
Metformin
Metformin
Metformin is used to manage blood sugar levels in people with type 2 diabetes. It is used off-label to induce weight loss, especially in high-risk individuals. Studies show that metformin may also cause weight loss by modulating appetite control centers in the hypothalamus and altering the gut microbiome.

Can I Buy Metformin from Invigor Medical?

Patients can purchase Metformin with an included prescription consultation with a doctor.
Clinical Formula
C4H11N5
FDA Designation
Biguanides
Other Names
Glucophage, Riomet, Fortamet, Glumetza
Category
For Use By
Delivery Method
Pill

Can I Buy Metformin?


Approved patients can buy Metformin (generic glucophage) with the included prescription consultation. After consulting with the doctor via an online Telewellness visit, and after the patient is approved, the medication is sent directly from the pharmacy.


Do We Offer Metformin as part of a treatment plan?
Yes
Insulin Sensitivity
Increase Insulin Sensitivity
Decrease Appetite
Metformin can help decrease appetite and cravings

How Does Metformin Work?

Metformin Can Support Weight Loss

Metformin decreases glucose production in the liver, decreases glucose absorption from the intestines, and improves insulin sensitivity. Metformin lowers blood glucose by about 25% to 30%, with a low risk for hypoglycemia. Proposed mechanisms of action for metformin that may support weight loss include:

  • Decrease in liver glucose production
  • Alter gut microbiome
  • Suppress appetite-stimulating brain cells in the hypothalamus
  • Increase leptin sensitivity
  • Appetite suppression by increasing lactate production
  • Reversal of age-related metabolic changes
  • Alter bile absorption
  • Changes signaling in the gut

Benefits of Metformin


Metformin has the following potential benefits:
  • Decrease blood glucose levels and glucose production in the liver
  • Support weight loss

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Drug Details

Indications

What is Metformin used for?

  • Metformin is medically indicated to treat type 2 Diabetes Mellitus.
  • Metformin is also used off-label to treat polycystic ovary syndrome.

Contraindications

When should you avoid Metformin?

  • Allergy or hypersensitivity to the medication or its ingredients
  • Severe renal impairment
  • Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
  • Type 1 diabetes mellitus
  • Use with caution in those who:
  • Have kidney disease
  • High ketone levels in the blood or urine
  • Congestive heart failure
  • Liver disease
  • Use insulin
  • Anemia
  • Have high alcohol consumption
  • Become easily dehydrated
  • Have a history of a heart attack
Metformin Side Effects

What are the side effects of Metformin?

Potential side effects from metformin include:
Common Metformin Side Effects
  • diarrhea
  • bloating
  • stomach pain
  • gas
  • indigestion
  • constipation
  • unpleasant metallic taste in mouth
  • heartburn
  • headache
  • flushing of the skin
  • nail changes
  • muscle pain
Rare Metformin Side Effects
  • More serious side-effects include chest pain and allergic reactions. Severe lactic acidosis may develop with symptoms such as muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, weak or tired.

Metformin Dosage Information

Metformin Dosage & Frequency

Typical Metformin Dosage & Frequency
  • 500-1000mg
  • Daily

References

  • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes
  • American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35(suppl1):S11-S63.
  • American Diabetes Association. Standards of medical care in diabetes-2014. Diabetes Care 2014;37(suppl1):S14-S80.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520185/
  • https://pubmed.ncbi.nlm.nih.gov/7623902/

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