How Does Metformin Synergy Work?
A Powerful Combination to Support Weight Loss
Metformin is used to decrease blood glucose and fat deposition in the liver and is used to treat type 2 diabetes. Researchers found that combining leucine, metformin, and sildenafil worked better than metformin alone at activating the 5′ adenosine monophosphate-activated protein kinase (AMPK)/Sirtuin 1 (Sirt1) pathway, which regulates glucose and fat metabolism in the liver. The combination also increases liver energy metabolism and decreases inflammation. Leucine is a direct Sirt1 activator. Sildenafil inhibits phosphodiesterase 5, which increases nitric acid and blood flow. This pathway also interacts with the sirtuin pathway as it stimulates Sirt1.
Vitamin B12 Deficiency Can Lead to Obesity
B12 is important in the formation of red blood cells and regulating gene activity. It is also used to produce myelin, the fatty insulator that surrounds nerve cells and speeds up nerve signaling throughout the body. Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels, according to researchers. B12 is involved in the regulation of DNA coding for proteins (epigenetics) as well as many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition.
Benefits of Metformin Synergy
Weight loss- Increased energy
- Boosted metabolism
- Improved lipid metabolism
- Decreased triglycerides
- Lower blood pressure
- Improved glucose metabolism
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