Metformin Synergy
Metformin Synergy
Metformin Synergy
Metformin synergy is a stack of three medications/nutrients that synergistically stimulate Sirt1, an enzyme that regulates energy and fat metabolism, along with B12, a vitamin that boosts energy levels, reduces fatigue, and kick-starts an otherwise sluggish metabolism.

Can I Buy Metformin Synergy from Invigor Medical?

Patients can purchase Metformin Synergy with an included prescription consultation with a doctor.
FDA Designation
For Use By
Delivery Method
Included Compounds

Can I Buy Metformin Synergy?

Approved patients can buy Metformin Synergy with the included prescription consultation. After consulting with the doctor via an online Telewellness visit, and after the patient is approved, the medication is sent directly from the pharmacy.

Do we offer Metformin Synergy as part of a treatment plan?
Enhances Glucose Metabolism
Increase Insulin Sensitivity and improves glucose utilization
Supports Weight Loss
Metformin can help decrease appetite and cravings
Boosts Energy
Reduce fatigue with B12

How Does Metformin Synergy Work?

A Powerful Combination to Support Weight Loss

Metformin is used to decrease blood glucose and fat deposition in the liver and is used to treat type 2 diabetes. Researchers found that combining leucine, metformin and sildenafil worked better than metformin alone at activating the 5′ adenosine monophosphate-activated protein kinase (AMPK)/Sirtuin 1 (Sirt1) pathway which regulates glucose and fat metabolism in the liver. The combination also increases liver energy metabolism and decreases inflammation. Leucine is a direct Sirt1 activator. Sildenafil inhibits phosphodiesterase 5 which increases nitric acid and increases blood flow. This pathway also interacts with the sirtuin pathway as it stimulates Sirt1.

Vitamin B12 Deficiency can Lead to Obesity

B12 is important in the formation of red blood cells and in regulating gene activity. It is also used to produce myelin, the fatty insulator that surrounds nerve cells that speeds up nerve signaling throughout the body. Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels, according to researchers. B12 is involved in the regulation of DNA coding for proteins (epigenetics) as well as many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition.

Benefits of Metformin Synergy

Potential benefits from using Metformin Synergy include:
  • Support weight loss
  • Increase energy
  • Boost metabolism
  • Improve lipid metabolism
  • Decrease triglycerides
  • Lower blood pressure
  • Improve glucose metabolism

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Drug Details


What is Metformin Synergy used for?

  • There are currently no medical indications for using Metformin Synergy.


When should you avoid Metformin Synergy?

  • Contraindications for prescribing metformin include:
  • Allergy or hypersensitivity to the medication or its ingredients
  • Severe renal impairment
  • Type 1 diabetes mellitus
  • Have kidney disease
  • High ketone levels in the blood or urine
  • Congestive heart failure
  • Liver disease
  • Insulin Use
  • Anemia
  • Have high alcohol consumption
  • Have a history of a heart attack
  • Eye problems or Leber's disease
  • Iron or folic acid deficiency
  • Any type of infection
  • Hypoglycemia
  • Stomach ulcers
Metformin Synergy Side Effects

What are the side effects of Metformin Synergy?

Potential side effects from metformin include:
Common Metformin Synergy Side Effects
  • Headaches
  • Heartburn
  • Diarrhea
  • Stomach pain
  • Indigestion
  • Constipation
  • Decreased urine output
  • Dizziness
  • Fast heartbeat
  • Loss of appetite
  • Flushing
  • Cough
Rare Metformin Synergy Side Effects
  • Unpleasant metallic taste in the mouth
  • Blue lips or fingernails
  • Sudden loss of vision in one or both eyes
  • Twice a day


  • Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial
  • Investigating the Synergistic effect of Leucine-Metformin-Sildenafil on Nonalcoholic Steatohepatitis
  • Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial
  • Vitamin B12
  • Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus. The Multicenter Metformin Study Group
  • Randomised Clinical Trial: A Leucine-Metformin-Sildenafil Combination (NS-0200) Vs Placebo In Patients With Non-Alcoholic Fatty Liver Disease
  • Metformin: Mechanisms in Human Obesity and Weight Loss
  • Long-Term Safety, Tolerability, and Weight Loss Associated with Metformin in the Diabetes Prevention Program Outcomes Study.
  • Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters
  • The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity

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