Metformin Synergy

Metformin synergy is a stack of three medications/nutrients that synergistically stimulate Sirt1, an enzyme that regulates energy and fat metabolism, along with B12, a vitamin that boosts energy levels, reduces fatigue, and kick-starts an otherwise sluggish metabolism.

Can I Buy Metformin Synergy from Invigor Medical?

Patients can purchase Metformin Synergy with an included prescription consultation with a doctor.

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Can I Buy Metformin Synergy?

Approved patients can buy Metformin Synergy with the included prescription consultation. After consulting with the doctor via an online Telewellness visit, and after the patient is approved, the medication is sent directly from the pharmacy.

Do We Offer Metformin Synergy as part of a treatment plan?

Yes

	Enhances Glucose Metabolism	Increase Insulin Sensitivity and improves glucose utilization
	Supports Weight Loss	Metformin can help decrease appetite and cravings
	Boosts Energy	Reduce fatigue with B12

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How Does Metformin Synergy Work?

A Powerful Combination to Support Weight Loss

Metformin is used to decrease blood glucose and fat deposition in the liver and is used to treat type 2 diabetes. Researchers found that combining leucine, metformin and sildenafil worked better than metformin alone at activating the 5′ adenosine monophosphate-activated protein kinase (AMPK)/Sirtuin 1 (Sirt1) pathway which regulates glucose and fat metabolism in the liver. The combination also increases liver energy metabolism and decreases inflammation. Leucine is a direct Sirt1 activator. Sildenafil inhibits phosphodiesterase 5 which increases nitric acid and increases blood flow. This pathway also interacts with the sirtuin pathway as it stimulates Sirt1.

Vitamin B12 Deficiency can Lead to Obesity

B12 is important in the formation of red blood cells and in regulating gene activity. It is also used to produce myelin, the fatty insulator that surrounds nerve cells that speeds up nerve signaling throughout the body. Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels, according to researchers. B12 is involved in the regulation of DNA coding for proteins (epigenetics) as well as many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition.

Benefits of Metformin Synergy

Potential benefits from using Metformin Synergy include:

Support weight loss
Increase energy
Boost metabolism
Improve lipid metabolism
Decrease triglycerides
Lower blood pressure
Improve glucose metabolism

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Metformin Synergy Treatment Plan

Anti-Aging, Energy, Weight Loss

Drug Details

Indications

What is Metformin Synergy used for?

There are currently no medical indications for using Metformin Synergy.

Contraindications

When should you avoid Metformin Synergy?

Contraindications for prescribing metformin include:
Allergy or hypersensitivity to the medication or its ingredients
Severe renal impairment
Type 1 diabetes mellitus
Have kidney disease
High ketone levels in the blood or urine
Congestive heart failure
Liver disease
Insulin Use
Anemia
Have high alcohol consumption
Have a history of a heart attack
Eye problems or Leber's disease
Iron or folic acid deficiency
Any type of infection
Hypoglycemia
Stomach ulcers

Metformin Synergy Side Effects

What are the side effects of Metformin Synergy?

Potential side effects from metformin include:

Common Metformin Synergy Side Effects

Headaches
Heartburn
Diarrhea
Stomach pain
Indigestion
Constipation
Decreased urine output
Dizziness
Fast heartbeat
Loss of appetite
Flushing
Cough

Rare Metformin Synergy Side Effects

Unpleasant metallic taste in the mouth
Blue lips or fingernails
Sudden loss of vision in one or both eyes

Twice a day

References

Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial
https://journals.lww.com/americantherapeutics/Abstract/2021/02000/Leucine_and_Sildenafil_Combination_Therapy_Reduces.1.aspx
Investigating the Synergistic effect of Leucine-Metformin-Sildenafil on Nonalcoholic Steatohepatitis
https://scholarworks.gsu.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1069&context=biology_theses
Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/33369909/
Vitamin B12
https://www.drugs.com/vitamin-b12.html
Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus. The Multicenter Metformin Study Group
https://pubmed.ncbi.nlm.nih.gov/7623902/
Randomised Clinical Trial: A Leucine-Metformin-Sildenafil Combination (NS-0200) Vs Placebo In Patients With Non-Alcoholic Fatty Liver Disease
https://onlinelibrary.wiley.com/doi/10.1111/apt.14674
Metformin: Mechanisms in Human Obesity and Weight Loss
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520185/#R15
Long-Term Safety, Tolerability, and Weight Loss Associated with Metformin in the Diabetes Prevention Program Outcomes Study.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308305/
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters
https://pubmed.ncbi.nlm.nih.gov/30569637/
The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity
https://clinicaltrials.gov/ct2/show/NCT03364335

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