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Phentolamine

Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa. It is typically used with papaverine to treat ED. Clinical studies show that phentolamine in combination with papaverine dilate blood vessels entering the penis, with an erection occurring within 20 to 30 minutes.

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Clinical Formula

C₁₇H₁₉N₃O

FDA Designation

Alpha-Adrenic Antagonist

Other Names

OraVerse, Regitine

Can I Buy Phentolamine?

Patients who qualify can purchase Phentolamine in the Bimix, Trimix, or Quadmix formulations for the treatment of Erectile Dysfunction.

Do we offer Phentolamine as part of a treatment plan?

Yes

Success Rate	80-95% success
Fast Acting	Works within minutes

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How Does Phentolamine Work?

Phentolamine Causes Muscle Relaxation and a Widening of Blood Vessels

Phentolamine is an alpha-adrenoceptor antagonist, which means that it blocks chemicals that bind to alpha-adrenergic receptors. Competitively binding to their receptors, phentolamine causes muscle relaxation and a widening of blood vessels. When blood vessels are widened, blood pressure decreases, and blood flow into the penis increases. Phentolamine also blocks 5-HT receptors, which cause the release of histamine from mast cells.

Benefits of Phentolamine

Used in combination with other vasodilators to treat erectile dysfunction.

Used in combination with other vasodilators to treat erectile dysfunction.
80-95% Success Rate with Papaverine

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Where do I Start?

Start by Selecting a Treatment Plan

Drug Details

Indications

What is Phentolamine used for?

Diagnosing a pheochromocytoma
Treat hypertensive crisis (extremely high blood pressure)
Treat ED (with papaverine)

Contraindications

When should you avoid Phentolamine?

Heart attack or a history of a heart attack
Angina
Known hypersensitivity or allergy to phentolamine

Phentolamine Side Effects

What are the side effects of Phentolamine?

Potential side effects to using phentolamine include:

Common Phentolamine Side Effects

Bruising or bleeding at the injection site
Burning along the penis
Swelling
Difficulty with ejaculation
Dizziness
Prolonged erection (priapism)
Lumps in the penis

Rare Phentolamine Side Effects

Phentolamine Dosage Information

Phentolamine Dosage & Frequency

Typical Phentolamine Dosage & Frequency

Customized Per Individual
As Needed

References

https://pubmed.ncbi.nlm.nih.gov/11402586/
https://go.drugbank.com/drugs/DB00692
https://pubmed.ncbi.nlm.nih.gov/3712604/
https://books.google.com/books?id=EpifDwAAQBAJ&pg=PA160&lpg=PA160&dq=Juenemann,+K.P.,+et+al.,+Hemodynamics+of+papaverine-+and+phentolamine-induced+penile+erection.+J+Urol,+1986.+136(1):+p.+158-61.&source=bl&ots=M4M8288rxw&sig=ACfU3U1Azfgp9dJYM-ezCDR9eFgUQH678Q&hl=en&sa=X&ved=2ahUKEwiyoO-K2NL1AhXxmuAKHfyHBlQQ6AF6BAgCEAM
https://www.drugs.com/sfx/phentolamine-side-effects.html

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