Phentolamine is an alpha-adrenergic antagonist that relaxes the smooth muscle lining the corpora cavernosa. It is typically used with papaverine to treat erectile dysfunction. Clinical studies show that phentolamine, in combination with papaverine, dilates blood vessels entering the penis, leading to an erection within 20 to 30 minutes.
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Can I Buy Phentolamine?

Patients who qualify can purchase Phentolamine in the Bimix, Trimix, or Quadmix formulations to treat erectile dysfunction.

Do we offer Phentolamine as part of a treatment plan?
Success Rate
80-95% success
Fast Acting
Works within minutes

How Does Phentolamine Work?

Phentolamine Causes Muscle Relaxation and a Widening of Blood Vessels

Phentolamine is an alpha-adrenoceptor antagonist, which means that it blocks chemicals that bind to alpha-adrenergic receptors. Competitively binding to their receptors, phentolamine causes muscle relaxation and a widening of blood vessels. When blood vessels are widened, blood pressure decreases, and blood flow into the penis increases. Phentolamine also blocks 5-HT receptors, which cause the release of histamine from mast cells.

Benefits of Phentolamine

Possible benefits of using Phentolamine:
  • Used in combination with other vasodilators to treat erectile dysfunction.
  • 80-95% success rate when used with Papaverine

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Drug Details


What is Phentolamine used for?

  • Diagnosing a pheochromocytoma
  • Treating hypertensive crisis (extremely high blood pressure)
  • Treating ED (with papaverine)


You should avoid Phentolamine if you are/have:

  • Had a heart attack or have a history of heart attacks
  • Angina
  • Known hypersensitivity or allergy to phentolamine
Phentolamine Side Effects

What are the side effects of Phentolamine?

Potential side effects to using phentolamine include:
Common Phentolamine Side Effects
  • Bruising or bleeding at the injection site
  • Burning along the penis
  • Swelling
  • Difficulty with ejaculation
  • Dizziness
  • Prolonged erection (priapism)
  • Lumps in the penis
Rare Phentolamine Side Effects
  • None

Phentolamine Dosage Information

Phentolamine Dosage & Frequency

Typical Phentolamine Dosage & Frequency
  • Customized Per Individual
  • As Needed



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