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Ornithine is an amino acid that reduces muscle fatigue by buffering acids in the blood and potentially increases muscle mass through its effects on growth hormone. It may also help with stress reduction and sleep quality.
Can I buy Ornithine from Invigor Medical?
For Use By
Delivery Method

Can I Buy Ornithine?

Patients can buy Ornithine in the Amino Blend formula with the included prescription consultation. Consult with the doctor via an online Telewellness visit. The pharmacy will send the medication directly to your door after approval.

Do we offer Ornithine as part of a treatment plan?
Muscle Performance
Reduces muscle fatigue
Natural GH Release
Increases muscle and bone density

How Does Ornithine Work?

Ornithine Increases Muscle Contractility and Muscle Mass

L-ornithine is a non-essential, non-protein amino acid. L-ornithine is part of the urea cycle, along with L-arginine and L-citrulline. Together, these amino acids help buffer ammonia in the blood. Ammonia activates the enzyme phosphofructokinase, which increases the production of lactate. This causes a decrease in muscle cell pH and calcium release, and therefore a decrease in muscle contractility. Increased ornithine may reverse these effects, increasing the length of muscle contractility before fatigue and allowing for a longer, more productive workout.

Ornithine and arginine promote the synthesis of growth hormone, which is expected to increase protein synthesis and muscle mass. However, the potential effect of ornithine on growth hormone release is not fully understood.

Other studies show that ornithine may improve mood and sleep quality by affecting the hypothalamus-pituitary-adrenal axis. In a study, it reduced cortisol levels, and study participants reported they felt less stressed and had a more restful sleep.

Benefits of Ornithine

L-ornithine, along with L-arginine and L-citrulline, acts in the citric acid cycle. This cycle buffers ammonia, a compound that reduces blood and muscle acidity. Increased acidity leads to earlier muscle fatigue. Potential benefits of L-ornithine include:
  • Ornithine
    Increased muscle mass
  • Ornithine
    Reduced muscle fatigue
  • Ornithine
    Faster recovery from a workout
  • Ornithine
    Increased endurance

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Drug Details


What is Ornithine used for?

  • Removing toxic ammonia from the body
  • Helps with muscle growth and repair


You should avoid Ornithine if you are/have:

Contraindications for prescribing or using L-ornithine include:
  • Allergy to L-ornithine or any of its components
  • Ornithine transcarbamylase deficiency
  • Breastfeeding
  • Pregnancy
Ornithine Side Effects

What are the side effects of Ornithine?

Serious side effects associated with ornithine are rare. Reported side effects include:
Common Ornithine Side Effects
  • Nausea
  • Diarrhea
  • Muscle cramps
  • Cough
Rare Ornithine Side Effects
  • None


  • Randomised Controlled Trial of the Effects of L-ornithine on Stress Markers and Sleep Quality in Healthy Workers
  • Ornithine-alpha-ketoglutarate Improves Skeletal Muscle Protein Synthesis as Assessed by Ribosome Analysis and Nitrogen Use After Surgery
  • Ornithine alpha-ketoglutarate Improves Wound Healing in Severe Burn Patients: A Prospective Randomized Double-Blind Trial Versus Isonitrogenous Controls
  • Ornithine Uptake by Rat Liver Mitochondria: Effect of Calcium and Arginine
  • Prevalent use of Dietary Supplements Among People who Exercise at a Commercial Gym
  • Effect of L-ornithine Hydrochloride Ingestion on Intermittent Maximal Anaerobic Cycle Ergometer Performance and Fatigue Recovery After Exercise
  • Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes
  • Ornithine Ingestion and Growth Hormone Release in Bodybuilders

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