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Ornithine

Ornithine is an amino acid that reduces muscle fatigue by buffering acids in the blood and potentially increases muscle mass through its effects on growth hormone. It may also help with stress reduction and sleep quality.

Where Can I Get Ornithine?

Can I Buy Ornithine from Invigor Medical?

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Clinical Formula

C₅H₁₂N₂O₂

FDA Designation

Amino Acid

Other Names

L-ornithine

Can I Buy Ornithine?

Patients can buy Ornithine in the Amino Blend formula with the included prescription consultation. Consult with the doctor via an online Telewellness visit. The medication is then sent directly from the pharmacy after approval.

Do we offer Ornithine as part of a treatment plan?

Yes

Muscle Performance	Reduces muscle fatigue
Natural GH Release	Increase muscle & bone density

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How Does Ornithine Work?

Ornithine Increases Muscle Contractility and Muscle Mass

L-ornithine is a non-essential, non-protein amino acid. L-ornithine is part of the urea cycle, along with L-arginine and L-citrulline. Together these amino acids help buffer ammonia in the blood. Ammonia activates the enzyme phosphofructokinase, which increases the production of lactate. This causes a decrease in muscle cell pH, a decrease in calcium release, and therefore a decrease in muscle contractility. Increased ornithine may reverse these effects—increasing the length of muscle contractility before fatigue, allowing for a longer, more productive workout.

Ornithine and arginine promote the synthesis of growth hormone, which is expected to increase protein synthesis and muscle mass. However, the potential effect of ornithine on growth hormone release is not fully understood.

Other studies show that ornithine may improve mood and sleep quality by affecting the hypothalamus-pituitary-adrenal axis. In a study, it reduced cortisol levels, and study participants reported they felt less stressed and had a more restful sleep.

Benefits of Ornithine

L-ornithine, along with L-arginine and L-citrulline, acts in the citric acid cycle. This cycle buffers ammonia, a compound that reduces blood and muscle acidity. Increased acidity leads to earlier muscle fatigue. Potential benefits of L-ornithine include:

Increased muscle mass
Reduced muscle fatigue
Faster recovery from a workout
Increased endurance

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Anti-Aging, Energy, Focus/Memory, Immunity, Recovery

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Anti-Aging, Energy, Focus/Memory, Immunity, Recovery

Drug Details

Indications

What is Ornithine used for?

L-ornithine is indicated to treat:
No current indications for L-ornithine

Contraindications

When should you avoid Ornithine?

Contraindications for prescribing or using L-ornithine include:
Allergy to L-ornithine or any of its components
Ornithine Transcarbamylase deficiency
Breastfeeding
Pregnancy

Ornithine Side Effects

What are the side effects of Ornithine?

Serious side effects associated with ornithine are rare. Reported side-effects include:

Common Ornithine Side Effects

Nausea
Diarrhea
Muscle cramps
Cough

Rare Ornithine Side Effects

References

Randomised Controlled Trial of the Effects of L-ornithine on Stress Markers and Sleep Quality in Healthy Workers

https://doi.org/10.1186/1475-2891-13-53
Ornithine-alpha-ketoglutarate Improves Skeletal Muscle Protein Synthesis as Assessed by Ribosome Analysis and Nitrogen Use After Surgery

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1493280/
Ornithine alpha-ketoglutarate Improves Wound Healing in Severe Burn Patients: A Prospective Randomized Double-Blind Trial Versus Isonitrogenous Controls

https://pubmed.ncbi.nlm.nih.gov/10890617/
Ornithine Uptake by Rat Liver Mitochondria: Effect of Calcium and Arginine

https://pubmed.ncbi.nlm.nih.gov/3453689/
Prevalent use of Dietary Supplements Among People who Exercise at a Commercial Gym

https://pubmed.ncbi.nlm.nih.gov/15467105/
Effect of L-ornithine Hydrochloride Ingestion on Intermittent Maximal Anaerobic Cycle Ergometer Performance and Fatigue Recovery After Exercise

https://pubmed.ncbi.nlm.nih.gov/21431425/
Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes

https://pubmed.ncbi.nlm.nih.gov/20300016/
Ornithine Ingestion and Growth Hormone Release in Bodybuilders

https://www.sciencedirect.com/science/article/abs/pii/S0271531705802659

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