Citrulline

L-citrulline is converted to L-arginine in the body. It increases nitric oxide which increases blood flow. People use L-citrulline to increase exercise endurance and stamina, treat erectile dysfunction and reduce fatigue.

Where can I Buy Citrulline?

Patients can Buy citrulline with an included prescription consultation with a doctor.

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Clinical Formula

C₆H₁₃N₃O₃

FDA Designation

Nutraceutical

Other Names

L-Citrulline, delta-Ureidonorvaline

Can I Buy Citrulline?

Approved patients can buy Citrulline in the Amino Blend formula with the included prescription consultation. Consult with the doctor via an online Telewellness visit. The medication is then sent directly from the pharmacy after approval.

Do We Offer Citrulline as part of a treatment plan?

Yes

	Increase Endurance	Meet your workout goals
	Reduce Fatigue	Increases overall energy

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How Does Citrulline Work?

CITRULLINE DECREASES FATIGUE AND INCREASES ENDURANCE

Citrulline is a non-essential amino acid that is produced in the body and is also found in watermelon, cucumber, squash, and pumpkin. In the body, L-citrulline is converted into L-arginine and L-ornithine. These three amino acids are part of the urea cycle which processes ammonia, a metabolic waste product. L-citrulline increases L-arginine, which increases nitric oxide. Increases in nitric oxide can increase blood flow to muscle, reducing fatigue, reducing energy expenditure, and increasing exercise endurance.

In another study, after oral supplementation with citrulline malate, participants reported reduced fatigue, a 34% increase in oxidative ATP production during exercise, and a 20% increase in phosphocreatine recovery rate after exercise. In another study, L-citrulline increased growth hormone levels, potentially due to increased arginine levels.

Benefits of Citrulline

L-citrulline increases L-arginine and nitric oxide which increases blood flow. Many of the benefits associated with L-citrulline use are a result of buffering ammonia levels and increasing blood flow. Supplementing with L-citrulline has the following potential benefits:

Better athletic performance
Improved exercise capacity
Reduced muscle fatigue
Faster post-exercise recovery
Improved erectile function

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Drug Details

Indications

What is Citrulline used for?

L-citrulline is indicated to treat:
Urea Cycle disorders

Contraindications

When should you avoid Citrulline?

Contraindications for prescribing or using L-citrulline include:
Allergy to L-citrulline or any of its components
Breastfeeding
Pregnancy
Liver disease
Kidney infection
May affect blood pressure

Citrulline Side Effects

What are the side effects of Citrulline?

Side effects associated with L-citrulline are rare. Reported side-effects include:

Common Citrulline Side Effects

Gastrointestinal upset
Heartburn
Cough

Rare Citrulline Side Effects

Diarrhea
Nausea
Vomiting

References

The Importance of Quality Specifications in Safety Assessments of Amino Acids: The Cases of L-Tryptophan and L-Citrulline
https://academic.oup.com/jn/article/146/12/2643S/4589958?login=false
Pharmacokinetic and Pharmacodynamic Properties of Oral L-Citrulline and L-Arginine: Impact on Nitric Oxide Metabolism
https://pubmed.ncbi.nlm.nih.gov/17662090/
L-Citrulline Supplementation: Impact on Cardiometabolic Health
https://doi.org/10.3390/nu10070921
Effect of L-Arginine or L-Citrulline Oral Supplementation on Blood Pressure and Right Ventricular Function in Heart Failure Patients with Preserved Ejection Fraction
https://pubmed.ncbi.nlm.nih.gov/21154265/
Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness
https://pubmed.ncbi.nlm.nih.gov/20386132/
Oral L-Citrulline Supplementation Enhances Cycling Time Trial Performance in Healthy Trained Men: Double-Blind Randomized Placebo-Controlled 2-way Crossover Study
https://pubmed.ncbi.nlm.nih.gov/26900386/
Citrulline/Malate Promotes Aerobic Energy Production in Human Exercising Muscle
https://doi.org/10.1136/bjsm.36.4.282
Oral L-Citrulline Supplementation Improves Erection Hardness in Men With Mild Erectile Dysfunction
https://pubmed.ncbi.nlm.nih.gov/21195829/
L-Citrulline-Malate Influence Over Branched Chain Amino Acid Utilization During Exercise
https://doi.org/10.1007/s00421-010-1509-4
Effects of L-citrulline Oral Supplementation on Polymorphonuclear Neutrophils Oxidative Burst and Nitric Oxide Production After Exercise
https://doi.org/10.1080/10715760903071664
L-Citrulline US FDA
https://www.fda.gov/media/109619/download

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