Bupropion

Bupropion is an antidepressant that is used off-label for weight loss. Its mechanism of action is not fully understood. It appears to affect monoamine uptake and inhibit the uptake of norepinephrine and dopamine. In a controlled clinical study, 200 patients taking bupropion lost an average of 9.7 pounds (nearly 5% of body weight). Bupropion seems to work in the hypothalamus, where it reduces cravings by activating POMC neurons, and in the mesolimbic area of the brain, which is a reward center stimulated by pleasurable activities like eating.

Can I buy Bupropion for weight loss from Invigor Medical?

Patients can purchase Bupropion for weight loss with an included prescription consultation with a doctor.

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Clinical Formula

C₁₃H₁₈ClNO

FDA Designation

Other Names

Zyban

Can I Buy Bupropion?

If you would like to purchase Bupropion for weight loss, learn about Bella+. This capsule supplements a reduced-calorie diet and exercise plan for a powerful weight management plan.

Do we offer Bupropion as part of a treatment plan?

Yes

Reduce Cravings

Modulate your brain’s reward center’s response

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How Does Bupropion Work?

Suppress Appetite

Bupropion does not affect serotonin levels, unlike other antidepressants, which means it lacks common side-effects associated with antidepressants such as sexual dysfunction, weight gain, and sedation. Its structure closely resembles that of diethylpropion, an appetite suppressant, and sympathomimetic agent.

Bupropion is an antidepressant that seems to affect monoamine uptake, antagonizes nicotinic receptors, and inhibits the uptake of norepinephrine and dopamine. It appears to affect monoamine uptake and inhibits the uptake of norepinephrine and dopamine. Inhibiting the reuptake of norepinephrine and dopamine may explain how bupropion acts in the brain. Bupropion affects dopamine and norepinephrine concentrations in both the nucleus accumbens and the prefrontal cortex in the brain.

Benefits of Bupropion

Potential benefits of bupropion:

Improve mood
Suppress appetite
Increase energy

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Where do I Start?

Start by Selecting a Treatment Plan

Drug Details

Indications

What is Bupropion used for?

Bupropion is medically indicated to treat depression
Seasonal affective disorder
Smoking cessation
It is used off-label to treat antidepressant induced sexual dysfunction
Attention-deficit hyperactivity disorder
Depression associated with bipolar disorder
Obesity

Contraindications

When should you avoid Bupropion?

An allergy to any of its components
Seizure disorders
Discontinuation of alcohol or sedatives
Arteriovenous malformations
Severe head injury
Severe stroke
Brain tumor
Significant central nervous system disease
Taking monoamine oxidase inhibitors, linezolid or methylene blue
History of suicidal ideation

Bupropion Side Effects

What are the side effects of Bupropion?

Bupropion carries a black box warning for its potential to cause suicidal ideation in young adults taking this medication. Some potential side effects from bupropion:

Common Bupropion Side Effects

drowsiness
anxiety
excitement
difficulty falling asleep or staying asleep
dry mouth
excessive sweating
ringing in the ears
changes in your sense of taste
frequent urination
dizziness
headache
nausea
vomiting
stomach pain
uncontrollable shaking of a part of the body
loss of appetite
weight loss
constipation
sore throat

Rare Bupropion Side Effects

Thoughts of suicide or dying
Attempts to commit suicide
New or worsening depression
New or worsening anxiety
An extreme increase in activity and talking (mania)
Other unusual changes in mood or behavior
Trouble sleeping (insomnia)
Elevated blood pressures
Feeling agitated or restless
Panic attacks
New or worse irritability
Acting aggressive, being angry or violent
Acting on dangerous impulses

Bupropion Dosage Information

Bupropion Dosage & Frequency

Typical Bupropion Dosage & Frequency

Individualized Dosage
As Needed

References

https://medlineplus.gov/druginfo/meds/a695033.html
https://medlineplus.gov/druginfo/meds/a695033.html
https://www.ncbi.nlm.nih.gov/books/NBK470212/
https://www.ncbi.nlm.nih.gov/books/NBK470212/
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ed2da3a6-0614-4bea-8e82-962cbaae6428
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ed2da3a6-0614-4bea-8e82-962cbaae6428
https://pubmed.ncbi.nlm.nih.gov/12376586/
https://pubmed.ncbi.nlm.nih.gov/12376586/
https://www.sciencedirect.com/science/article/pii/S0149291800883010
https://www.sciencedirect.com/science/article/pii/S0149291800883010
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1163271/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1163271/
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2002.86
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2002.86

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