Bella
Bella supplements a reduced-calorie diet and exercise plan for long-term weight management. In three clinical trials, the combination of bupropion and naltrexone was more effective in reducing body weight than diet and exercise alone. Oxytocin and metformin independently also have modest effects on weight loss. Together they are an unbeatable combination.

Can I Buy Bella from Invigor Medical?

Patients can Buy Bella with an included prescription consultation with a doctor.

Can I Buy Bella?


Approved patients can buy Bella with the included prescription consultation. After consulting with the doctor via an online Telewellness visit, and after the patient is approved, the medication is sent directly from the pharmacy.


Do We Offer Bella as part of a treatment plan?
Yes
Reduces Body Fat
Reduces cravings and manage satiety
Improve Mood
Decreases anxiety, promotes better sleep, and increases energy
Enhances Sexual Satisfaction
Promotes bonding and increases libido

How Does Bella Work?

Bupropion and Naltrexone: A Powerful Combination to Reduce Cravings and Modulate Appetite

Bella is made up of six drugs that are all known for their ability to support weight loss. Bupropion is a norepinephrine reuptake inhibitor, and naltrexone is an opioid receptor antagonist. Bupropion and naltrexone work together in the hypothalamus to reduce cravings and hunger. They activate POMC neurons in the hypothalamus, a brain region that produces a neurotransmitter that decreases the desire to eat. In the mesolimbic area of the brain, a reward center in the brain that is stimulated by pleasurable activities such as eating, bupropion, and naltrexone can regulate these feelings of pleasure, reducing cravings to eat.

Oxytocin Reduces Calorie Intake and Suppresses Cravings

Oxytocin is a nine amino acid peptide hormone made in the hypothalamus. In animal studies, administering oxytocin caused sustained weight loss by reducing food intake, increasing energy expenditure, and inducing fat breakdown. Oxytocin may also affect blood sugar control, a benefit independent of weight loss benefits. When oxytocin nasal spray was tested in humans, it led to similar effects, weight loss, decreased caloric intake, increased fat breakdown, and improved insulin sensitivity.

Vitamin B12 Boosts Metabolism

Vitamin B12 may help fight fatigue, boost energy, and support weight loss efforts. Vitamin B12 is a water-soluble vitamin that is involved in forming DNA and red blood cells. Research on how vitamin B12 affects metabolism is very limited. However, vitamin B-12 deficiency seems to be associated with an increased risk of obesity. In another study that enrolled over 9,000 people, having high levels of B12 was associated with a lower risk of obesity.

Topiramate Helps with Appetite Control

Topiramate is an anti-seizure medication for treating epilepsy and migraines that were found to have weight loss as a side effect. When tested in clinical trials, topiramate induced weight loss and improved blood sugar control in adults with type 2 diabetes and obesity. Some users report that topiramate alters their sense of taste, which may help with appetite control.

Metformin Controls Blood Sugar

Metformin is used to control blood sugar in people with type 2 diabetes. Large studies have also demonstrated its weight-loss potential. Metformin may modulate appetite control centers in the hypothalamus and alter the gut microbiome. The Diabetes Prevention Study showed that metformin decreased the risk of type 2 diabetes in at-risk patients by 31% in a three-year period. Weight loss was about 4 pounds. The weight was kept off over a 10-year follow-up period. Weight loss strongly depended on adherence to the diet.

Benefits of Bella


Bella+ is a combination of six drugs that function in different ways to minimize cravings and suppress appetite, making it easier to control your hunger. Though the primary advantage of using Bella+ is weight loss, you may also experience improved mood, increased energy, and improved cognition.
  • Support weight loss
  • Decreased appetite
  • More energy
  • Improved mood
  • More restful sleep
  • Improved mental clarity
  • Decreased cravings and increased satiety
  • Decreased anxiety
  • Enhanced libido
  • Increased strength
  • Better glucose utilization

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Where do I Start?

Start by Selecting a Treatment Plan

Drug Details

Indications

What is Bella used for?

  • There are no medical indications for Bella.

Contraindications

When should you avoid Bella?

  • Eating disorders
  • Mood disorders
  • Opioid addiction
  • Pregnant
  • Seizures
  • Heart disease
  • High blood pressure
  • Alcohol misuse
  • Liver or kidney disease
  • Drug addiction
Bella Side Effects

What are the side effects of Bella?

Potential side effects of Bella include:
Common Bella Side Effects
  • Headache
  • Blurred vision
  • Tachycardia
  • Metallic taste
  • Rash
  • Itching/swelling
  • Nausea and Vomiting
  • Loss of Appetite
  • Fever
  • Chills
Rare Bella Side Effects
  • Changes in mood such as anxiety, depression, panic attacks, trouble sleeping, agitation, thoughts of suicide
  • Allergic reaction/anaphylaxis
  • Vision problems that may be permanent if not rapidly treated
  • Problems with speech or memory
  • Severe skin reaction with a red or purple skin rash and blistering.
  • Once a day

References

  • Bupropion and Naltrexone
    https://www.drugs.com/mtm/bupropion-and-naltrexone.html
  • Naltrexone and Bupropion
    https://medlineplus.gov/druginfo/meds/a619020.html
  • Oxytocin During the Initial Stages of Romantic Attachment: Relations to Couples’ Interactive Reciprocity
    https://www.sciencedirect.com/science/article/abs/pii/S0306453012000029?via%3Dihub
  • Differential Effects of Intranasal Oxytocin on Sexual Experiences and Partner Interactions in Couples
    https://doi.org/10.1016/j.yhbeh.2014.01.009
  • Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans
    https://doi.org/10.1523/JNEUROSCI.5538-09.2010
  • From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
    https://doi.org/10.3389/fnins.2015.00497
  • ‘Trust Hormone’ Oxytocin Helps Old Muscle Work Like New, Study Finds
    https://news.berkeley.edu/2014/06/10/oxytocin-helps-muscle-regeneration/
  • Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal Administration
    https://doi.org/10.3389/fnins.2012.00174
  • Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies
    https://dx.doi.org/10.3390%2Fnu12071925
  • Naltrexone/Bupropion (Contrave) for Weight Loss
    https://www.aafp.org/afp/2015/0415/p554.html
  • Oxytocin Nasal Spray Improves Self-control in Overweight Men
    https://www.eurekalert.org/news-releases/619423
  • Contrave
    https://contrave.com/
  • The Effects of Oxytocin on Eating Behaviour and Metabolism in Humans
    https://dx.doi.org/10.1038%2Fnrendo.2017.115
  • Metformin: Mechanisms in Human Obesity and Weight Loss
    https://dx.doi.org/10.1007%2Fs13679-019-00335-3

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