Medically reviewed by Leann Poston, M.D. on 9/23/2020
One out of every two American adults suffers from some sort of musculoskeletal injury (American Academy of Orthopedic Surgeons, 2016). That means that half of us experience chronic pain or dysfunction in our joints, muscles, or bones. Depending on the specific tissues affected, these injuries can be extremely debilitating and potentially incredibly difficult to heal. Joint structures, tendons, and ligaments are classified as hypovascular, meaning they have relatively few blood vessels compared to the rest of our body. This lack of blood supply results in a prolonged healing process and an increased potential for reinjury.
Currently, the standard of care for musculoskeletal injuries and pain management involves the use of corticosteroids. Despite their aggravating effects on tissue, corticosteroids remain the primary, albeit controversial, treatment for such injuries due to a lack of other viable options. Short of surgical interventions (of which there are an estimated 300,000 for tendon and ligament repair alone in the United States each year (Pennisi, 2002)), there just aren’t many choices. Fortunately, our bodies may have provided us with exactly that, an option – the incredibly promising compound called BPC-157. We will break down the important details of BPC-157 and discuss where you can get it and if you should buy BPC-157 online.
BPC-157 has actually been around the scientific research community for quite a while. People wanting to buy BPC-157 online has been a newer thing, however. It was first introduced and overviewed in the Journal of Physiology by Sikirić et al. back in 1993. What is most fascinating is its origin within the human body. BPC-157, or Body Protection Compound 157, is a fifteen amino acid fragment of a protein found in gastric juice; although it is technically considered synthetic because it is not found in the stomach in this particular form (Bódis et al. 1997).
BPC-157’s tissue-regenerative ability isn’t limited to our stomachs, however. In fact, BPC-157 has been found to promote increased healing and repair in nearly every kind of tissue in which it has been studied. We will briefly touch on the potential benefits of BPC-157 across the body because they are incredibly fascinating. Our primary focus however will be its effects on musculoskeletal repair, potential mechanisms of action, what to do before trying BPC-157, and where you can find reliable, quality sources of this body-protecting compound.
The Physiology of BPC-157
BPC-157 circulates systemically whether it is taken orally or injected subcutaneously. We also know that it is attracted to signaling molecules produced by injured tissues, yet the exact mechanism with which it heals is not known for certain and likely varies depending on the particular tissue and nature of the injury (Gwyer, Wragg & Wilson, 2019).
Although the mechanism(s) of action are not fully understood, the scientific literature has identified some potential sources of this compound’s healing power, including its effect on the FAK-paxillin pathway (focal adhesion kinase – an enzyme present in injured tissues), nitric oxide, increased VEGF (vascular endothelial growth factor) activity, and the upregulation of growth hormone receptors in injured tissues. VEGF specifically is responsible for angiogenesis, or the creation of new blood vessels and is the most likely mechanism through which BPC-157 is able to promote the healing of joint structures, tendons, and ligaments as it allows for an increased delivery of nutrients and various healing factors that are required for growth and repair (Hsieh et al., 2017).
Most joint structures, ligaments, and tendons are composed primarily of different kinds of collagen and their healing can benefit from increases in collagen production stimulated by BPC-157. As we mentioned, these structures lack a sufficient blood supply for quick healing so they have a relatively slow healing process. Even once they have healed they still lack the structural integrity they had prior to the injury. For this reason many people have looked to buy BPC-157 online but some precautions need to be taken.
Administration methods for BPC-157
BPC-157 has traditionally been administered through an injection near the injury site. Injected medications have a much lower rate of patient compliance than easier administration routes such as oral delivery. One of the biggest obstacles to oral administration of any therapy is the stomach’s volatile, acidic environment. Fortunately, BPC-157 is stable in this kind of environment, thanks to the fact that it was derived from gastric juice. Yet another unique quality of this peptide is its ability to be administered through various routes and still be efficacious. In fact, every route of administration tested thus far has yielded positive healing outcomes. Researchers have tested BPC-157 administration orally via tablets and infused in drinking water, topically via transdermal patches and creams, rectally, and through intraperitoneal (abdominal) injections (Gwyer, Wragg & Wilson, 2019).
The benefits of BPC-157
This amazing compound also has many potential benefits outside of helping musculoskeletal repair and recovery. It is currently being researched for effects on neurological disorders, inflammation, and it has profound evidence for healing gut issues such as lesions caused by non-steroidal anti-inflammatory drugs (NSAIDS). This is especially interesting because, with the exception of opioids, the primary medication utilized for chronic joint pain and other such ailments are NSAIDs. This class of medications is proving to have more and more side effects with prolonged usage by the population as a whole. If BPC-157 does indeed prove effective for not only healing the issues that were once treated with NSAIDs and corticosteroids but also reversing or mitigating damage caused by them, it would be a vast improvement over these outdated practices.
One commonly prescribed corticosteroid named 6alpha-methylprednisolone is incredibly effective at reducing inflammation and pain, but it comes with a whole host of unwanted side effects including delayed healing of injured tissue. One study looked at the co-administration of BPC and 6alpha-methylprednisolone, and the results were astounding. BPC-157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally and demonstrated functionally, macroscopically, and histologically at all investigated intervals (Pevec et al., 2010).
Due to its unique status somewhere between a supplement and a pharmaceutical drug, BPC-157 has not been extensively studied in humans. However, in the human trials that have been done, as well as in the clinical application that has already taken place, there have been essentially no reported adverse events. Those that have been reported come through anecdotes primarily and consist of digestive issues and nausea (Chung-Hsun et al., 2011).
Before trying to buy BPC-157 online for musculoskeletal injuries and dysfunction, you should assess potential nutritional deficiencies as well as possible behavioral/lifestyle issues that may be at the root of your joint, bone, or muscle pain. Consistent and prolonged sitting, poor exercise form, inactivity, fatty acid deficiency, and other factors may be contributing to chronic pain or discomfort, and addressing them will help ensure BPC-157 has a positive effect.
More research is certainly needed for BPC-157 to become the standard of care for musculoskeletal injuries. However, it is undoubtedly the most promising compound available for this purpose. Its lack of adverse events in trials and the fact that it has no known toxicity levels should be encouraging enough for those suffering to give it a try. Surgery does not promise a solution to the chronic pain experienced by 50% of American adults, and the side effect profile of NSAIDs and corticosteroids demands an alternative treatment be developed.
Buy BPC-157 online
There are various websites out there that are all racing to provide BPC-157 and other peptides at the lowest cost possible. This inevitably results in companies cutting corners and providing products that are either diluted or contain none of the advertised compounds. Your best bet is to visit a wellness or anti-aging clinic, which sources their peptides from a compounding pharmacy that has an excellent track record as well as client testimonials to back it up.
Another fantastic option is to buy BPC-157 online through a telehealth clinic like Invigor Medical that allows you to obtain advice from a licensed medical professional, receive a prescription, and order products all in the same place. There are few compounds that show as much promise as BPC-157, and it is likely to improve the quality of life for countless people suffering from joint and muscle pain in the coming years. Undoubtedly it should be considered as a part of your injury and pain recovery protocol.
While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.
- American Academy of Orthopaedic Surgeons. (2016). One in two Americans have a musculoskeletal condition: New report outlines the prevalence, scope, cost and projected growth of musculoskeletal disorders in the U.S.. ScienceDaily. Retrieved from www.sciencedaily.com/releases/2016/03/160301114116.htm
- Pennisi E (2002) Tending Tender Tendons. Science 295:1011–1011
- Sikirić, P. et al. (2003). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal of Physiology-Paris, Volume 87, Issue 5, Pages 313-327
- Bódis B, Karádi O, Németh P, Dohoczky C, Kolega M, Mózsik G (1997) Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells. Life Sci 61:PL243–PL248
- Gwyer, D., Wragg, N.M. & Wilson, S.L. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res 377, 153–159 (2019). https://doi.org/10.1007/s00441-019-03016-8
- Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JH (2017) Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med 95(3):323–333
- Pevec, Danira, et al. “Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application.” Med Sci Monit, 2010; 16(3): BR81-88
- Chung-Hsun Chang, Wen-Chung Tsai, Miao-Sui Lin, Ya-Hui Hsu, and Jong-Hwei Su Pang. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology 2011 110:3, 774-780