Warning: Undefined array key "titleWrapper" in /home/customer/www/invigormedical.com/public_html/wp-content/plugins/seo-by-rank-math/includes/modules/schema/blocks/toc/class-block-toc.php on line 103
Skip to main content

Trimix Gel vs. Trimix Injections: Which is More Effective?

Jun 17, 2023
Trimix Gel vs. Trimix Injections: Which is More Effective?
Between 22% and 35% of men do not have satisfactory results when using oral ED medications or have a medical contraindication to using these medications.1

Trimix comprises three medications: papaverine, phentolamine, and prostaglandin. Three medications work synergistically to increase blood flow into the penis and treat erectile dysfunction (ED). In many cases, ED is due to decreased blood flow to the penis. Contributing factors are aging, obesity, increased blood glucose or cholesterol, high blood pressure, and trauma. ED can be caused by many other factors unrelated to blood flow, such as stress or depression. In these cases, Trimix is not the best treatment option. Let’s learn more about Trimix gel.

What is Trimix?

In many cases, men choose phosphodiesterase class 5 (PDE-5) inhibitors, such as Cialis or Viagra, as a first-line treatment for ED. Between 22% and 35% of men do not have satisfactory results when using oral ED medications or have a medical contraindication to using these medications.1 In one study of 116 men in whom both oral ED and penile injectables were successful, one-third of the men preferred penile injectables over oral medications.2 Trimix has proven to be 80% effective for helping men with ED maintain an erection long enough to have sex.

The three medications in Trimix:4

  • Papaverine is a medication that relaxes smooth muscles in blood vessels and dilates them to increase blood flow into the penis.
  • Phentolamine is another medication that relaxes smooth muscles in blood vessels and dilates them to increase blood flow into the penis.
  • Alprostadil is an approved medication to treat ED that relaxes the smooth muscle that makes up the structure of the penis and dilates blood vessels supplying blood to the penis, which stiffens the penis for an erection.

Trimix is available by prescription only. A compounding pharmacy prepares it, making it possible to modify the dosages and offer each man a unique ED treatment.

Trimix Gel vs. Trimix Injections: Which is More Effective?

What is a penile injection?

An estimated 30 million men in the United States and 150 million men worldwide are affected by ED. The American Urological Association considers penile injections one of the most effective non-surgical solutions for treating ED.5 Men may choose penile injections over oral ED medications for many reasons, including the side effect profile, contraindications to using the oral ED medications, ease of use, and a lack of systemic side effects.

Penile injections are administered into the side of the penis using a short, very fine needle. The medication is quickly injected into a cavernous space on the side of the penis, and pressure is applied for at least 5 minutes. In most cases, penile injections begin to work in 10 to 15 minutes, and their effects last for 30 to 60 minutes.

How often can you use Trimix injections?

Follow your doctor’s dosing instructions, but generally, penile injections should not be used more than once in 24 hours, more than two days in a row, or more than two or three times in a week. To minimize side effects, advise your doctor of all other medications you are taking, especially ED medications. Taking oral ED medications with penile injections can increase the risk of side effects. Some oral ED medications can stay in your system for several days, so let your doctor know if you have taken one of these medications within the week before the planned use of Trimix.  

A doctor Trimix gel

What is Trimix gel?

Trimix gels have been available in two forms: a topical and an intraurethral gel. According to one study, while Trimix topical gel is more stable and easier to use than Trimix injections, the results are frequently unsatisfactory due to poor absorption. Intraurethral Trimix gel is applied to the top of the penis at the urethral opening. In a study that involved 42 men with ED, after using intraurethral gel, 40.4% of men had an erection firm enough for penetrative sex. The authors suggest that more research and larger studies are needed.6

What is the average cost of Trimix gel?

No current prices were available with an online search. Trimix gel is only available by prescription from a compounding pharmacy, but according to some online sources, the manufacturer may have stopped producing it.

How long does it take for Trimix gel to work?

Trimix powder is mixed with a gel. An adaptor piece is attached to the end of the syringe. The adaptor is held firmly against the urethral opening, and the medication is pushed into the urethra. Gently pinch the tip of the urethra and massage the glans around the end of the penis. Like Trimix injections, Trimix gels are expected to work in about 10 minutes and last for about 30 minutes.

While Trimix gels are not rated as very effective, Trimix injections are well-tested and very effective. The success rate for penile injections, such as Trimix, ranges from 54% to 100%, with marked differences noted across the wide range of medication combinations and doses available. Satisfaction rates for penile injections range from 46% to 98.8%.5


When deciding to buy Trimix, understanding the effectiveness between Trimix gel and Trimix injections is crucial. Trimix injections have proven to be highly effective, with a success rate ranging between 54% to 100%. For comprehensive insights on efficacy, usage, and to make an informed decision about which form of Trimix is suitable for you, Invigor Medical provides valuable resources and guidance on their website. Visit Invigor Medical to explore your options and purchase the right ED injection for your needs.

Frequently Asked Questions

How often can Trimix gel be used?

The frequency of Trimix gel use depends on individual needs and healthcare provider recommendations. Typically, Trimix gel is applied as needed for erectile dysfunction (ED), with dosage and frequency determined based on factors such as the severity of ED and individual response to the medication. It’s important to follow healthcare provider instructions carefully and not exceed the recommended dosage or frequency of use.

How long does Trimix gel keep you hard?

The duration of effectiveness for Trimix gel can vary among individuals and depends on factors such as dosage, individual response, and level of sexual stimulation. Trimix gel is typically applied directly to the penis and absorbed through the skin to induce an erection. It’s important to follow healthcare provider instructions regarding dosage and timing to optimize the duration of the erection and minimize the risk of complications such as priapism.

How can I make Trimix work better?

To optimize the effectiveness of Trimix gel, it’s important to follow healthcare provider instructions carefully. This includes ensuring proper application technique, dosage, and timing. Additionally, maintaining overall health through regular exercise, a balanced diet, and managing underlying health conditions can support the effectiveness of Trimix gel treatment. Open communication with a healthcare provider about any concerns or difficulties with Trimix gel can also help tailor treatment for better results.

Does Trimix gel have to be refrigerated?

Trimix gel may need to be refrigerated depending on the specific formulation and storage instructions provided by the manufacturer or healthcare provider. It’s essential to follow proper storage guidelines to maintain the stability and effectiveness of the medication. Consulting with a healthcare provider or pharmacist can provide specific guidance on how to store Trimix gel properly.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

Trimix Gel vs. Trimix Injections: Which is More Effective?

Leann Poston, M.D.

Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.


  • Guay AT, Perez JB, Jacobson J, et al. Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J Androl. 2001;22:793–7. https://pubmed.ncbi.nlm.nih.gov/11545291/
  • Bennarchik, C. Kottwitz, M. & Geiger, S. (2010). Self-injection, Transurethral, and Topical therapy in Erectile Dysfunction. https://link.springer.com/chapter/10.1007/978-3-319-31587-4_14
  • Coombs, P. G., Heck, M., Guhring, P., Narus, J., & Mulhall, J. P. (2012). A review of outcomes of an intracavernosal injection therapy programme. BJU International, 110(11), 1787–1791. https://pubmed.ncbi.nlm.nih.gov/22564343/
  • Jain A, Iqbal OA. Alprostadil. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK542217/
  • Burnett AL, Nehra A, Breau RH et al: Erectile dysfunction: AUA guideline. J Urol 2018; 200: 633.
  • Marmar JL, Harkins TJ, Riordan J (May 2008). “Studies with Trimix gel in men who failed phosphodiesterase inhibitors”. Journal of Urology. 179 (4S): 431. doi:10.1016/s0022-5347(08)61264-1


Fill out the form below, and one of our treatment specialists will contact you.

Featured Articles

Trimix Gel vs. Trimix Injections: Which is More Effective?

Is Sex Good For Your Health?

Sex, whether alone or with a partner, has many health benefits, and a few risks as well. Sex positively impacts mental and physical health.
Trimix Gel vs. Trimix Injections: Which is More Effective?

Sermorelin and Alcohol: Is it Safe to Mix the Two?

Sermorelin is a synthetic growth hormone secretagogue. It is a small peptide made up of 29 amino acids. It stimulates the release of natural growth hormone from your pituitary gland. Many people us…

Medication Information: Oxytocin

Everything you need to know about Oxytocin.