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Erectile Dysfunction

Everything You Need To Know About Trimix Injections

This article will serve as a guide to frequently asked questions about Trimix injections. It will cover basic information such as what Trimix is and what it is used to treat for curious but casual readers. We will also discuss how to buy Trimix injections online in a safe manner. Additionally, this article will touch on more detailed information, such as a Trimix antidote, side effects, and costs, for readers who may be considering a purchase more seriously. This piece will provide a great starting point for anyone interested in learning more about or possibly even intending to buy Trimix.

As with any medication, it’s important to get all of your questions about Trimix answered before you begin taking it. Here’s everything you need to know about Trimix Injections.

What Is Trimix?

Trimix is an injectable medication made up of three different medications: papaverine, prostaglandin, and phentolamine. It is used as a treatment for erectile dysfunction. Trimix dosages vary depending on each client’s individual needs, and in some cases, a fourth medication is prescribed for clients who need a more powerful compound called atropine. When atropine is included, the combination of the 4 medications is commonly called QuadMix.

buy trimix online

Is Trimix Safe To Use?

Yes, Trimix is safe to use. Injectables for the treatment of erectile dysfunction were first developed in 1983, and since then, researchers have determined that Trimix appears to be safe and effective. Trimix should not be used by men who are allergic to any of its components, have a condition that predisposes to priapism (prolonged erection), have an anatomical deformity of the penis, or are taking any medications that interfere with blood clotting (McVary, 2010).

How Does It Work?

Trimix is injected directly into the shaft of the penis. It causes the blood vessels in the penis to dilate, increasing blood flow to the area, resulting in an erection.

Trimix Injections
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Trimix Injections

Trimix Injections are used as a second-line treatment when oral ED medications don’t work.

Learn About Trimix Injections

How Long Does It Last?

The effectiveness and duration of Trimix vary from person to person. Generally, it takes effect in around five minutes and can last anywhere from one to two hours, but erections can last longer.

Trimix Antidote

Trimix injections typically wear off naturally, but you may need medication to reverse its effects. This condition of prolonged erection is called priapism and left untreated, can result in damage to the structure of the penis. The incidence of priapism with Trimix ranges from 0% to 3.7% of users (Seyam et al., 2005). Norepinephrine, pseudoephedrine, and phenylephrine are commonly used to restore normal blood flow.

Trimix Vs. Oral ED Medications

Oral erectile dysfunction medications don’t work for everyone, and some people can’t take them for health reasons. Trimix commonly works for individuals who can’t take oral ED medications or for whom those medications are ineffective (Coombs et al., 2012).

Do The Injections Hurt?

Most users report minimal pain or discomfort when using Trimix injections. Proper injection technique can minimize pain and side effects. In one large study conducted by Mulhall et al. (1999), 4.9% of men discontinued Trimix injections due to pain.

Trimix Side Effects

Because it is administered locally, the side effects of Trimix are minimal. There may be some irritation at the injection site. Priapism is the most common side effect; if Trimix’s effects do not wear off after three hours, you should seek medical attention immediately (Seyam et al., 2005).

What Is The Right Dose Of Trimix?

The “right” dose of Trimix varies from person to person. What works for you might not be effective for someone else. It can take time to find the right dosage, and you’ll typically start with a small dose while you and your physician work to find the right one for you.

Does It Require A Prescription?

Yes, Trimix does require a prescription from a physician.

Where Can I Buy Trimix?

You can easily buy Trimix online through Invigor Medical. They are an online wellness clinic that specializes in men’s health.


While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider.  You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 


  1. Seyam, R., Mohamed, K., Akhras, A. et al. A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1Int J Impot Res 17, 346–353 (2005).
  2. Trissel, L.A., & Zhang, Y. (2004). Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction. International Journal of Pharmaceutical Compounding; Edmond Vol. 8, Iss. 3: 231-235.
  3. McVary, K. (2010). Contemporary Treatment of Erectile Dysfunction: A Clinical Guide. United Kingdom: Humana Press.
  4. Coombs, P. G., Heck, M., Guhring, P., Narus, J., & Mulhall, J. P. (2012). A review of outcomes of an intracavernosal injection therapy programme. BJU International110(11), 1787–1791.
  5. Mulhall JP, Jahoda AE, Cairney M, et al. The causes of patient dropout from penile self-injection therapy for impotence. J Urol. 1999 Oct;162(4):1291–1294.

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Published: Sep 22, 2019


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