Checklist Before You Buy Trimix

Decisions When You Buy Trimix

Medically reviewed by Leann Poston M.D. on 9/8/20

If you’ve tried oral erectile dysfunction medications and haven’t seen satisfactory results, then Trimix injections may be the ideal solution.  Hopefully, you’ve done some reading and research on our site and elsewhere, and are fully aware of how Trimix works, the low rate of side effects, and high efficacy.  If not, we encourage you to do so!  Even if you’re well-informed about Trimix injections themselves, however, there are a lot of important decisions you will need to make when you buy Trimix. 

This is true whether you buy Trimix from Invigor Medical or another provider (such as your local pharmacy).  Here, we’re not talking about choosing your source to buy Trimix, but rather the decisions you’ll need to make about how much Trimix to purchase, how frequently to refill your prescription, and so on.  In this guide, we’ll look at some of these key decisions that you’ll need to make when you buy Trimix, and provide you with guidance and information to help make your purchasing experience as stress-free as possible. 

Trimix Overview

First, let’s start with a brief recap about Trimix.  Trimix is an injectable medication to treat erectile dysfunction.  It is actually made up of three separate medications – papaverine, alprostadil, and phentolamine – which work in slightly different ways to relax the blood vessels and increase blood flow to the penis.  It is delivered via a local injection into the penis, approximately 5 to 20 minutes before sexual activity.  In upwards of 90% of men, Trimix effectively treats erectile dysfunction and produces an erection satisfactory for sexual intercourse.  In most cases, a single Trimix injection lasts for one to two hours.

Trimix is not a first-line treatment for ED, however.  It is meant for men who have been diagnosed with erectile dysfunction and have not had success with oral ED medications.  Studies indicate that while popular oral ED medications are effective for about 70% of cases of ED, the remaining 30% of men may need something stronger – Trimix.  Therefore, most men who are looking to buy Trimix, or try it out for the first time, see it as their last hope short of surgery for regaining erectile function and enjoying sex in their life.

In both instances, it’s important to remember that these treatments don’t reverse the underlying causes of erectile dysfunction, such as diabetes, cardiovascular problems, and so on, and you should always check with your doctor or prescriber to ensure you are healthy enough for sexual activity prior to starting Trimix treatment.

You Can’t Buy Trimix without a Prescription

Like oral ED medications, Trimix is not available over-the-counter.  You can’t buy Trimix without a prescription from a licensed medical practitioner in the US.  Several reasons for this are especially apparent in the case of Trimix.  For example:

  • Unlike oral ED medications, Trimix is only suitable for use locally in the penis.  Mistakenly injecting it into the veins could cause potentially deadly effects.
  • As an injectable medication, Trimix requires users to understand how to properly clean the injection site, draw a dose from the vial, and administer the injection.  Discussion and review with a doctor or other health professional are required to ensure this is done correctly and minimize the risk of any side effects (such as injection-site infection) that can otherwise occur.
  • Excessive use (too often or too much) of Trimix may result in erections that don’t go away on their own.  As so many ED pill ads from the 1990s and 2000s made clear, erections lasting longer than 4 hours are a medical emergency and require immediate medical intervention to avoid potentially permanent damage to the penis. 
  • Trimix needs to be kept refrigerated or frozen, especially after opening a vial.  Proper handling and storage information needs to be provided to patients to ensure the medication is effective and safely used.
  • Since Trimix is a compounded medication, made up of three constituent parts, it needs to be made by a compounding pharmacy.  It is not supplied in a pre-mixed form in a bottle by a manufacturer, but rather made to order by a licensed compounding pharmacy.  This is similar to many other compounded drugs and explains why a pharmacy (and therefore a prescription) must be involved to buy Trimix. 

For all of these above reasons and more, patients looking to buy Trimix need to either visit their doctor or have a telemedicine health consultation to obtain clearance and a prescription for Trimix.  It can then be subsequently filled, either at your local pharmacy of choice in the case of a doctor visit or online and delivered to your home within about a day when you choose a telemedicine provider like Invigor Medical

Important Decisions When You Buy Trimix

Depending on whether you purchase Trimix online through a telemedicine provider or your primary care doctor and local pharmacy, you may have different levels of control or input into some key decisions about buying Trimix.  In both cases, it’s important to be honest and frank – either with your doctor or yourself – to make the best possible decisions on your required dosage.  

There may be other factors not mentioned here that are unique to you and your health or medical circumstances.  Therefore, you are encouraged to always talk to your prescriber about those concerns or issues prior to filling your prescription when you buy Trimix, regardless of where you choose to do so. 

Trimix Dosage

One of the biggest factors governing how much Trimix you may need (and what supplied amount to choose) will be the size of the dosage your doctor has approved.  Typically, most new patients are started on a dosage between 5 units (0.05 mL) and 20 units (0.2 mL).  Dosage may need to be adjusted several times to find what works ideally for you, but should only be done at the direction of a doctor over a period of time.  You should not take extra Trimix or adjust your dosage yourself.  Higher dosage rates tend to result in a higher risk of side effects, such as erections requiring medical attention. 

The dosage will dictate how many uses you’ll get out of a single vial or purchase of Trimix, and therefore how much you may need to fill at any given time.  Most pharmacies – both local and online – have pre-set volumes or amounts available when you buy Trimix, and may offer one or a handful of size options, such as 5 mL, 10 mL, and so on.  Obviously, at say 0.25 mL, you will get fewer uses or doses (20 in fact) out of a 5 mL vial than someone taking 0.1 mL (50 doses). 


Another key decision that comes into play when you buy Trimix is the medication’s storage and shelf-life.  Trimix must be stored refrigerated or frozen.  Prior to opening a vial, it should be frozen to ensure maximum shelf-life, which is about 6 months to 1 year.  A few days prior to opening a new vial, it should be put in the refrigerator.  You should only take it out when you actually are taking a dose out of the vial, and then promptly return it to the refrigerator.  In the refrigerator, it should last about 2 to 3 months.

It’s important to note that nothing harmful happens if Trimix isn’t properly stored.  Rather, it loses some of its potency and efficacy.  So it won’t be harmful to use, it just won’t have the desired effect – which defeats the purpose of why you would buy Trimix or other ED treatments in the first place!  Therefore, proper storage is essential. 

When Trimix is shipped, it is usually shipped on ice and can be taken for travel in a cooler or similar insulated carrier with an ice pack.  In these instances, a fresh, unopened vial is best, as there is less chance for loss of potency when the vial is still sealed.  That’s one of many reasons why initial shipping is often done on ice when you buy Trimix online, but it is not a cause for concern if the ice has melted or the medication is room temperature by the time it has arrived.  In tests, 5 days of room temperature exposure of a sealed vial of Trimix resulted in a loss of potency of about 10%.  So you obviously want to ensure it is refrigerated or frozen, but should not be concerned about the time in transit – simply put it into cold storage one way or the other as soon as you receive it at your home. 

What all of this means is that you shouldn’t buy Trimix to stockpile a huge amount that you might not use before it expires.  Even in the freezer, the best-case scenario is about 1 year of shelf-life from the time you receive the medication.  Given restrictions on use frequency (as we’ll discuss later in this guide), there’s a reasonable upper limit on how much Trimix you need at any given time, based on your dosage and other considerations we’re outlining here.  This is one case where buying in bulk doesn’t necessarily save you money – and may end up costing you a lot in wasted, ineffective expired medication down the road. 

Frequency of Safe Use

As mentioned above, there’s a governing frequency for safe use of Trimix that will form a natural limit on how much you may need at any given time or as part of any single purchase when you buy Trimix from your chosen source.  Specifically, it is meant to be used no more than 3 times per week – never more than once per day, and never more than 2 days in a row.  What that means in terms of how much you need will depend on dosage and the other factors and decisions we’re discussing here.

For example, if your dosage is 0.2 mL/20 units, then the most you would need per week, assuming you use every opportunity for safe use, is around 0.6 mL/60 units – maybe a bit more to account for losses when preparing the syringe or inaccuracies in measuring.  That would mean something like 2.5 mL or so would be suitable per month.  A purchase of a 5 mL vial would make the most sense, as that would give you a two-month supply in your refrigerator, well within the refrigerated shelf-life.  You could also buy additional vials to keep frozen if you so choose.  Buying a 10 mL vial or larger wouldn’t make much sense, as you’d likely not use it all up before it expired and lost its potency and efficacy – something like 20-25% of it would go to waste.

Frequency of Sex

Related to the above criteria, you’ll need to make a decision about or at least have a sense of your likely frequency of sexual activity when you buy Trimix.  That includes partnered activity and masturbation – any activity that would require an erection via Trimix injection.  If you plan to use every opportunity (3 times per week) that is safe as per the above, that’s great!  If you and your partner only have sex occasionally, such as once per month, and you don’t plan to use it much more often than that, then that’s just as great!  Whatever works for you is fine!  The important thing is to know, or at least have a good estimate, so that you can calculate how much you need, and make the best choice among the available sizes and vial quantities when you go to buy Trimix/have your prescription filled. 

History of Trimix Use

If you’ve never used Trimix before, it will be much harder to estimate your potential dosage, and therefore the amount you may need in a given period of time than if you are established on a stable dose.  As discussed above, adjustments to dosing should only be made in small increments over time, as directed by your doctor or prescriber.  Therefore, it’s best to start with a smaller vial option than a larger one, as you won’t have a good sense of how much you may need per dose, or how effective the medication may be for you.  You can always refill your prescription and choose a larger volume the next time you buy Trimix, after all. 

Periodic Reassessment

Finally, you need to consider periodic reassessment.  If your ED is the result of a health condition, for example, that you are actively working to improve, your need for Trimix may diminish over time.  On the other hand, ED can also get worse over time.  Health, medication, and related life circumstances can change.  Therefore, it’s useful to periodically re-evaluate and reassess your dosage, frequency of use, and needs.  This should also take into account how frequently you have “extra” Trimix left beyond the expiration date, or if you routinely run out before you thought you would.  Those factors can help you make the best decisions on volume, refill frequency, and related matters when buying Trimix. 

Frequently Asked Questions

How much Trimix should I use?

The amount of Trimix that you should use in a single dose will vary considerably based on a number of factors.  As discussed in our article, you should only take the amount prescribed and directed by your doctor.  Adjustments frequently need to be made at the start of treatment, to find the right level for you.  Most doctors will start you on 0.05 mL to no more than 0.2 mL initially and gradually increase the dosage based on your feedback.  As the risk for prolonged erection side effects (which are a medical emergency) tends to increase at higher doses, you should only ever use the lowest effective dose.

Can Trimix be stored at room temperature or frozen?

Trimix is designed to be stored in either refrigerator or freezer temperatures.  It can initially reach room temperature in transit or prior to receipt by a patient and may come up to room temperature briefly when you take it out to use it.  However, when not taking out a dose, it should be stored in the refrigerator or freezer.  One important note, however – always take a vial out of the freezer a few days before the intended use, and put it in the refrigerator.   Do not attempt to use frozen Trimix with a syringe, and do not refreeze a vial that has already been opened/punctured. 

What is the recommended frequency of use for Trimix?

Trimix is not designed for use more often than three times a week.  It should not be used more than two days in a row, and doses should be spaced at a minimum of 24 hours apart.  This will help minimize the risk of side effects, particularly a prolonged erection (an erection lasting longer than 4 hours, medically known as priapism), which is a medical emergency and requires immediate medical attention in order to avoid long-term permanent damage to your penis. 

Invigor Medical – The Best Place to Buy Trimix Injections

Hopefully, you now have a better sense of the things to think about and decisions and calculations you may need to make before you buy Trimix.  There’s no reason to stress out about it, but having a sense of how much you may need and how much you will use can help you save money by ensuring you don’t end up with a lot of expired medication.  There’s no need to stockpile Trimix, especially when you choose a telemedicine provider like Invigor Medical since you can refill and re-order at any time.  Your medication will be delivered typically within 1 day, so you don’t need to worry about running out at the wrong moment, either. 


While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider.  You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 

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