Trimix Injections | The How to Guide

Reviewed by Leann Poston M.D. on 9/8/20

What are Trimix Injections?

Trimix is an erectile dysfunction medication made by special compounding pharmacies. Injectable medications have been used since 1983 to treat ED and are considered the most effective non-surgical solution for ED, according to the American Urologic Association (American Urological Association, 2018). Trimix consists of three medications that each have certain properties that, when combined, help men get and maintain an erection. You can buy Trimix injections online through respected companies that partner with U.S. licensed compounding pharmacies.

Trimix has proven to be 80% effective for helping men with ED maintain an erection long enough to have sex (Coombs et al., 2012). It is administered with a tiny insulin needle that is injected into the shaft of the penis. Despite the penis being a sensitive area, most nerves are in the head and not the shaft so with good injection techniques pain is not an issue for most men using Trimix. In one large study conducted by Mulhall et al. (1999), only 4.9% of men discontinued treatment due to pain from injections.

The Trimix Compound

The three medications that formulate Trimix are Papaverine, Alprostadil/Prostaglandin, and Phentolamine. Each medication increases blood flow into the penis, helping with erectile dysfunction, and the combination has proven to be a strong solution for ED treatment.

Buy TriMix Injections Online

Papaverine helps to dilate blood vessels. Prostaglandin helps to relax the blood vessels and dilates arteries in the penis. Phentolamine relaxes and dilates the blood vessels and also increases the output from your heart (Duncan et al, 2019).

Dilating and relaxing blood vessels while increasing cardiac output is the primary goal.  Basically, the compound has been formulated to maximize all three medications’ benefits and minimize the side effects.

Each person reacts differently to medications. For this reason, it should be expected that the dosage may need to be adjusted several times in order to get the right custom formula for each individual. This can be a balancing act. For best results, you should see a doctor that specializes in Trimix and use a pharmacy that specializes in compounding Trimix.

Side Effects of Trimix

Since Trimix is injected locally and not directly into the bloodstream the possible expected side effects are minimal. The major side effect is from infection secondary to improper cleaning of the injection site prior to application. Other possible side effects, though unlikely, can include an allergic reaction to one of the three medications in Trimix and an erection lasting longer than 4 hours. This condition is called priapism and left untreated, can result in damage to the structure of the penis. The incidence of priapism with Trimax ranges from 0% to 3.7% of users (Seyam et al., 2005).

How to Administer

Here is the summarized version: Hold the penis by the head and pull it to straight out. Inject the syringe in the middle third of the shaft of the penis at either the 9-11 or 1-3 o’clock position avoiding any veins. Apply pressure if there is any bleeding. When you receive your medication, it will have more detailed step by step instructions.

Where to Buy TriMix Injections Online

Trimix can be compounded at any compounding pharmacy. We do recommend getting Trimix from a national compounding pharmacy that specializes in Trimix. Experienced compounding pharmacies can ensure that accurate and consistent dosing is provided.

Trimix is a prescribed medication and must be prescribed by a licensed practitioner. It is also helpful to consult with a practitioner who has clinical experience with prescribing Trimix.

buy trimix injections online

The largest national telemedicine company that specializes in Trimix is Invigor Medical. They work with the world’s largest compounding pharmacy for Trimix. Invigor Medical’s platform has proven successful for thousands of patients. You select the medication desired, fill out the intake form, arrange a call from a doctor to evaluate whether you are a good candidate for Trimix, get a prescription, the doctor sends the script to the pharmacy, and the pharmacy mails the medication to you. All of these steps can be done using your smartphone on the Invigor Medical website.


While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider.  You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 


  1. American Urological Association. (2018). Erectile Dysfunction: AUA Guidelines. Retrieved from
  2. Coombs, P. G., Heck, M., Guhring, P., Narus, J., & Mulhall, J. P. (2012). A review of outcomes of an intracavernosal injection therapy programme. BJU International110(11), 1787–1791.
  3. Mulhall JP, Jahoda AE, Cairney M, et al. The causes of patient dropout from penile self-injection therapy for impotence. J Urol. 1999 Oct;162(4):1291–1294.
  4. Duncan, C., Omran, G.J., Teh, J. et al. Erectile dysfunction: a global review of intracavernosal injectables. World J Urol 37, 1007–1014 (2019).
  5. Seyam, R., Mohamed, K., Akhras, A. et al. A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1Int J Impot Res 17, 346–353 (2005).