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How To Use Trimix Injections

Oct 24, 2019
How To Use Trimix Injections

Trimix is an erectile dysfunction medication made by special compounding pharmacies. Injectable medications have been used since 1983 to treat ED and are considered the most effective non-surgical solution for ED, according to the American Urologic Association (American Urological Association, 2018). Trimix consists of three medications that each have certain properties that, when combined, help men get and maintain an erection. Want to learn more about how to use Trimix injections? You can buy Trimix injections online through respected companies that partner with U.S. licensed compounding pharmacies.

Trimix has proven to be 80% effective for helping men with ED maintain an erection long enough to have sex (Coombs et al., 2012). It is administered with a tiny insulin needle that is injected into the shaft of the penis. Despite the penis being a sensitive area, most nerves are in the head and not the shaft so with good injection techniques pain is not an issue for most men using Trimix. In one large study conducted by Mulhall et al. (1999), only 4.9% of men discontinued treatment due to pain from injections.

The Trimix Compound

The three medications that formulate Trimix are Papaverine, Alprostadil / Prostaglandin, and Phentolamine. Each medication increases blood flow into the penis, helping with erectile dysfunction, and the combination has proven to be a strong solution for ED treatment.

Papaverine helps to dilate blood vessels. Prostaglandin helps to relax the blood vessels and dilates arteries in the penis. Phentolamine relaxes and dilates the blood vessels and also increases the output from your heart (Duncan et al, 2019).

How To Use Trimix Injections

Dilating and relaxing blood vessels while increasing cardiac output is the primary goal.  Basically, the compound has been formulated to maximize all three medications’ benefits and minimize the side effects.

Each person reacts differently to medications. For this reason, it should be expected that the dosage may need to be adjusted several times in order to get the right custom formula for each individual. This can be a balancing act. For best results, you should see a doctor that specializes in Trimix and use a pharmacy that specializes in compounding Trimix.

Side Effects Of Trimix

Since Trimix is injected locally and not directly into the bloodstream the possible expected side effects are minimal. The major side effect is from infection secondary to improper cleaning of the injection site prior to application. Other possible side effects, though unlikely, can include an allergic reaction to one of the three medications in Trimix and an erection lasting longer than 4 hours. This condition is called priapism and left untreated, can result in damage to the structure of the penis. The incidence of priapism with Trimix ranges from 0% to 3.7% of users (Seyam et al., 2005).

Trimix Injections
Mentioned Product

Trimix Injections

Trimix Injections are used as a second-line treatment when oral ED medications don’t work.

Learn About Trimix Injections

How To Use Trimix Injections

Here is the summarized version: Hold the penis by the head and pull it to straight out. Inject the syringe in the middle third of the shaft of the penis at either the 9-11 or 1-3 o’clock position avoiding any veins. Apply pressure if there is any bleeding. When you receive your medication, it will have more detailed step by step instructions.

How To Use Trimix Injections

Where To Buy Trimix Injections Online

Trimix can be compounded at any compounding pharmacy. We do recommend buying Trimix from a national compounding pharmacy that specializes in Trimix. Experienced compounding pharmacies can ensure that accurate and consistent dosing is provided.

Trimix is a prescribed medication and must be prescribed by a licensed practitioner. It is also helpful to consult with a practitioner who has clinical experience with prescribing Trimix.

How To Use Trimix Injections

Frequently Asked Questions

Where do you inject Trimix for best results?

For best results, Trimix injections are typically administered into the corpus cavernosum of the penis. The injection is usually given along the side of the penis, avoiding the central area where the urethra is located. This allows the medication to be absorbed into the erectile tissue, facilitating the erection process. It’s essential to follow proper injection technique and receive guidance from a healthcare provider to ensure safety and effectiveness.

How do you use Trimix for the first time?

When using Trimix for the first time, it’s crucial to follow your healthcare provider’s instructions carefully. They will typically provide detailed guidance on dosage, injection technique, and any precautions or potential side effects to be aware of. Before administering the injection, it’s important to thoroughly wash and sanitize the injection site and equipment to reduce the risk of infection. Additionally, it may be helpful to practice proper injection technique under the supervision of a healthcare provider to ensure comfort and accuracy.

How deep should a Trimix injection be?

The depth of a Trimix injection depends on individual anatomy and healthcare provider guidance. Generally, the needle is inserted into the erectile tissue of the penis to ensure proper delivery of the medication. Healthcare providers typically provide instructions on the appropriate depth and angle for administering the injection to optimize effectiveness and minimize discomfort.

How long will Trimix last in a syringe?

The duration of Trimix in a syringe can vary depending on factors such as storage conditions and the specific formulation of the medication. It’s important to follow proper storage guidelines provided by the pharmacy or healthcare provider to maintain the stability and effectiveness of the medication. Typically, Trimix should be used promptly after preparation to ensure potency and safety. Unused Trimix should be discarded according to healthcare provider or pharmacy instructions to avoid the risk of contamination or degradation.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.


  • American Urological Association. (2018). Erectile Dysfunction: AUA Guidelines. https://www.auanet.org/guidelines/erectile-dysfunction-(ed)-guideline
  • Coombs, P. G., Heck, M., Guhring, P., Narus, J., & Mulhall, J. P. (2012). A review of outcomes of an intracavernosal injection therapy programme. BJU International, 110(11), 1787–1791. https://proxy.oplin.org:2447/10.1111/j.1464-410X.2012.11080.x
  • Mulhall JP, Jahoda AE, Cairney M, et al. The causes of patient dropout from penile self-injection therapy for impotence. J Urol. 1999 Oct;162(4):1291–1294. https://www.auajournals.org/doi/abs/10.1016/S0022-5347%2805%2968269-9
  • Duncan, C., Omran, G.J., Teh, J. et al. Erectile dysfunction: a global review of intracavernosal injectables. World J Urol 37, 1007–1014 (2019). https://doi.org/10.1007/s00345-019-02727-5
  • Seyam, R., Mohamed, K., Akhras, A. et al. A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1. Int J Impot Res 17, 346–353 (2005). https://doi.org/10.1038/sj.ijir.3901313


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