Skip to main content

Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?

Mar 30, 2023
Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?
6% of people under age 60 and nearly 20% of people over age 60 have a B12 deficiency.1

Depression affects about 322 million people worldwide. It has many causes and contributing factors, and vitamin B12 deficiency is thought to be one of them. However, depression is a complex condition, and its pathophysiology is not fully understood. If you have a vitamin B12 deficiency and take supplements to replenish your vitamin B12 supplies, your depression symptoms may improve.

While the research is still incomplete, some studies indicate that higher vitamin B12 levels may help with depression. If you are struggling with depression, talk to your doctor, psychologist, or counselor to get an accurate diagnosis, rule out physical causes, and develop a treatment plan to improve your symptoms.

Why Are Some People Vitamin B12 Deficient?

Vitamin B12, also known as cobalamin, is a vitamin that you must get in your diet or through supplements because your body cannot produce it. Many people have difficulty absorbing vitamin B12 from their diet or consume a vegan diet low in vitamin B12. This may put them at an increased risk for B12 deficiency. Excessive alcohol consumption and poor diet can also contribute to B12 deficiency.2

Vitamin B12 is stored in your liver, so it usually takes years to develop a vitamin B12 deficiency. However, about 6% of people under age 60 and nearly 20% of people over age 60 have a B12 deficiency.1 The symptoms are not obvious and can be hard to diagnose.

What Does Vitamin B12 Do In Your Body?

Vitamin B12 has several important roles in the body, including:1

  • Helping to produce energy by converting food into glucose
  • Maintaining healthy nerve function
  • Making DNA, the genetic material in all cells
  • Helping to form red blood cells
  • Helping enzymes to function as a cofactor
  • Controlling homocysteine levels

Vitamin B12 deficiency can cause several health problems, including anemia, nerve damage and dysfunction, and neurologic symptoms such as memory loss, difficulty concentrating, and mood disorders.

Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?

Does Vitamin B12 Reduce Depression?

Vitamin B12 is necessary to produce energy in the body and to produce neurotransmitters such as serotonin and dopamine. Neurotransmitters are chemicals in the brain that send messages between nerves that regulate mood and thinking. Serotonin and dopamine are two neurotransmitters that are important for mood regulation. Since vitamin B12 is important in synthesizing brain chemicals, it makes sense that a vitamin B12 deficiency would cause decreased serotonin and dopamine production.

Clinical Trials And Depression

In clinical trials, low vitamin B12 levels were associated with severe depression. About 20% of patients with psychiatric illnesses also have vitamin B12 deficiency. However, clinical trials often show no symptom improvement when vitamin B12 levels are restored to normal. Patient age, sex, or other factors may determine whether vitamin B12 supplementation improves depressive symptoms.3

In another study, patients with low and normal vitamin B12 levels were randomized to either receive vitamin B12 or a placebo. Patients who received vitamin B12 supplementation with antidepressants had marked improvement in their depressive symptoms over patients who received antidepressants alone.4

While some studies suggest that supplementing with vitamin B12 can help with depression in people with B12 deficiency, depression is a complicated medical condition that is not fully understood.

People with vitamin B12 deficiency may also have increased homocysteine levels.3  Increased homocysteine in the bloodstream is an indicator of vitamin B12 and folate deficiency. In a  large study in Norway, increased homocysteine levels were associated with an increased risk of depression.5

Taking vitamin B12, along with other treatments for depression, may improve depressive symptoms. However, it is not likely to help with depression if you are not vitamin B12 deficient.

a woman who appears depressed.

How Much B12 Do I Take For Depression?

In one study, researchers found that higher vitamin B12 doses are associated with better depression treatment outcomes. The researchers suggest a dose of 1 milligram of vitamin B12 daily. However, more research is needed to support this recommendation.5

If you are B12 deficient, clinical trials suggest that restoring vitamin B12 levels, along with other antidepressant therapies, may improve depression and prevent relapses. Talk with your doctor to see if you need lab work to determine your B12 status and to rule out any other medical conditions that may contribute to your symptoms. Increase dietary sources of vitamin B12 and consider taking a supplement to restore your vitamin B12 levels.

Depression Is A Serious Medical Condition

Depression is a serious medical condition that can impact all aspects of your life. Talk with your healthcare provider to develop a treatment plan that meets your needs and goals.

If you have questions about vitamin B12 injections, contact one of the Invigor Medical treatment specialists.

Incorporating Vitamin B12 into your health regime could be a transformative step towards alleviating depression symptoms, especially if you’re deficient in this vital nutrient. Research suggests that appropriate B12 supplementation, alongside other treatments, may brighten your mood and enhance overall well-being. If you’re considering adding Vitamin B12 to your diet for its potential mood-lifting benefits, buy Vitamin B12 today.

Frequently Asked Questions

How long does it take for B12 to improve mood?

The timeframe for B12 to improve mood can vary. Some people may notice mood improvements within a few days to a week after starting supplementation, while for others, it may take longer.

What is the right amount of B12 to take daily?

The appropriate daily dosage of B12 depends on individual factors such as age, dietary intake, and specific health conditions. Generally, the recommended daily intake for adults is 2.4 micrograms. However, higher doses may be recommended for individuals with deficiencies or certain health conditions.

What happens if I take B12 everyday?

Taking B12 daily is generally safe for most people, as it is a water-soluble vitamin that the body can excrete any excess of. However, it’s essential to follow recommended dosages to avoid potential side effects or interactions with other medications.

Can you take too much vitamin B12?

While vitamin B12 is generally considered safe, taking excessively high doses over an extended period may lead to potential side effects such as diarrhea, itching, or even nerve damage. It’s important to stick to recommended dosages and consult a healthcare professional if you have concerns about B12 supplementation.

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.

Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?

Leann Poston, M.D.

Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.


  • Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ : British Medical Journal. 2014;349:g5226. doi:10.1136/bmj.g5226
  • Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. Sep 15 2017;96(6):384-389.
  • Seppälä J, Koponen H, Kautiainen H, Eriksson JG, Kampman O, Leiviskä J, Männistö S, Mäntyselkä P, Oksa H, Ovaskainen Y, Viikki M, Vanhala M, Seppälä J. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study. BMC Psychiatry. 2013 May 24;13:145. doi: 10.1186/1471-244X-13-145. PMID: 23705786; PMCID: PMC3674945.
  • Syed EU, Wasay M, Awan S. Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial. Open Neurol J. 2013 Nov 15;7:44-8. doi: 10.2174/1874205X01307010044. PMID: 24339839; PMCID: PMC3856388.
  • Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005 Jan;19(1):59-65. doi: 10.1177/0269881105048899. PMID: 15671130.


Fill out the form below, and one of our treatment specialists will contact you.

Featured Articles

Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?

Lipo Injections Reviews And Thoughts

Have you struggled with your weight your whole life? Or maybe recently you’ve put on a few extra pounds and can’t seem to lose that extra weight? Lipotropic injections may be just the weight loss s…
Brightening The Mood: How Much Vitamin B12 Is Needed For Relief From Depression?

Sermorelin: A Comprehensive Guide to an Anti-Aging Peptide

Aging, an inevitable journey for all, is not a disease but a natural process that brings its own set of challenges. That does not mean that we have to passively accept the outcomes of aging. Anti-a…

Medication Information: Sildenafil

Everything you need to know about Sildenafil.