Sermorelin vs Ipamorelin
Medically Reviewed by Leann Poston, M.D. on 9/11/2020
Nothing gets done in the human body without a signal. This signal can come in many forms, but it is often a hormone of some kind. Hormones are able to stop, start, enhance, or restrict the actions of glands, tissues, organs, and systems all over the body. Imagine we were able to do the same thing, controlling processes throughout the body by introducing the signal we need. Well, we live in an amazing time because one of the most recent breakthroughs in the fields of biological signaling and anti-aging is the harnessing of peptides. Peptides all originate from various compounds that occur naturally within the body, but we are now able to create, control, and utilize them for a variety of purposes.
Research and real-world application have proven them to help slow down the aging process, increase muscle mass, decrease fat mass, reduce inflammation, and heal the gut. There may be countless other potential uses waiting to be discovered. Two peptides that are brilliant examples of what modern medicine can do to slow down the aging process are sermorelin acetate (typically just referred to as sermorelin) and ipamorelin. It’s only natural to compare sermorelin vs. ipamorelin. These two signaling molecules mimic natural hormones within the body to stimulate the release of growth hormone from the pituitary gland. Not only do they have the ability to stimulate the production and release of your own body’s growth hormone, but they are able to do so in a way that is safe and complementary with one another.
This synergistic effect is exactly why practitioners are seeing incredible results combining these two peptides, and their combined ability will be the primary focus of this article. We will also cover how they differ from one another, the potential side effects of each, and where to buy peptides online to ensure that you are getting the highest quality product and service possible. Peptides are quickly positioning themselves at the forefront of personalized medicine, and they may have the ability to improve your quality of life drastically. How they can do it may seem like something out of a science fiction novel, but the science, application, and real-world experience of people all over the world is proving it to be anything but fiction.
Let’s start by breaking down some of the mystery around peptides. As you know, peptides are essentially just signaling molecules that have been derived from, or are compounds already found within the body. Sermorelin and ipamorelin are both categorized as growth hormone secretagogues which are nothing more than a substance that promotes secretion or release of a chemical messenger like a hormone. In this case, specifically, it means they promote the production and secretion of growth hormone from the amazing hormone factory in your brain called the pituitary gland. What is most interesting is that they accomplish this task in vastly different, yet complementary ways.
How Does Sermorelin Work?
Sermorelin stimulates the production and release of growth hormone in a relatively straightforward way – it mimics growth hormone-releasing hormone (GHRH). You don’t need to know much about the endocrine system to guess what GHRH does – it causes the release of growth hormone. GHRH is normally released from another location within your brain called the hypothalamus, and then it travels to the pituitary gland, binds to its receptors, and stimulates the release of growth hormone. When it is administered in the form of sermorelin, however, it travels through the bloodstream and binds to GHRH receptors in the pituitary gland (Prakash & Goa, 1999). As we said, the way sermorelin works in the body is pretty straightforward. Ipamorelin on the other hand will take quite a bit more explanation.
How Does Ipamorelin Work?
Ipamorelin acts in a completely different way to stimulate growth hormone release. To understand it fully, we need to quickly cover an entirely new hormone that we have yet to discuss called ghrelin. Ipamorelin mimics ghrelin in exactly the same way sermorelin mimics GHRH. Ghrelin doesn’t get as much attention as some of the A-list hormones like insulin, growth hormone, testosterone, and estrogen, but it absolutely should. Only discovered in 1999, ghrelin has profound regulatory effects on your metabolism, including increasing or decreasing hunger, inhibiting stored fat breakdown, and perhaps most importantly for this article, the release of growth hormone.
Ghrelin is one of three hormones which together act to regulate growth hormone release from the pituitary gland. The first is GHRH (sermorelin). Then there is somatostatin (which stops the release of growth hormone). Last but not least is ghrelin, which also stimulates the release of growth hormone but using a different receptor (Tritos & Kokkotou, 2006)
Now that you have an idea of how ghrelin works, understanding how a peptide that mimics ghrelin is able to initiate the release of growth hormones should be pretty easy. Ipamorelin binds to ghrelin receptors on the pituitary gland, switching them on in the same way that ghrelin naturally would. These on-switches are completely separate from the ones that sermorelin activates, enabling them to work synergistically to accomplish the same task and do so with no effect on the rest of your body’s hormones. There is always one major concern that must be evaluated whenever you are considering any kind of anti-aging treatment, however, and that is whether the benefits outweigh the potential side-effects. Fortunately, in the case of sermorelin vs. ipamorelin, that choice seems pretty easy.
Side Effects of Sermorelin vs Ipamorelin
Neither sermorelin nor ipamorelin has side effects that are likely to cause anyone looking for help turning back the hands of time to steer clear of them. In fact, ipamorelin is widely considered one of the safest and most effective peptide treatments available. Sermorelin has been known to cause flushing, headaches, nausea, dizziness, and redness or swelling around the injection site for some people. Ipamorelin’s possible side effects mirror that of sermorelin, with headaches and nausea topping the list of infrequent occurrences caused by the impressively safe peptide. Both peptides are largely safe and side effects free when used in the doses prescribed by a qualified medical practitioner (Merriam et al, 2001).
Knowing what that dosage is is yet another reason why it is important to purchase your peptides from a reputable source. Unfortunately, there really is no shortage of websites selling inferior products containing little or no actual peptides online. However, buying peptides online can be done safely and easily with a bit of education first.
Finding a company you can trust comes down to a few things. First, look for a website that requires you to speak to a medical professional to obtain a prescription. To buy ipamorelin or sermorelin online, you must have a prescription just like you would at any pharmacy. Many telehealth companies are able to walk you through this entire process from the convenience of your smartphone. If the company doesn’t require a prescription, find one that does! Second, look for a company that has a solid track record with customer feedback and reviews to back it up. If they are a solid company, they will undoubtedly have testimonials from patients who have worked with them in the past. Buying peptides online may have been questionable in the past, but the industry has evolved, and there are now many companies that provide excellent service, products, and results.
Ipamorelin and sermorelin are two peptides that have an excellent record of safety and effectiveness. Those looking for the physiological and psychological benefits of naturally increasing growth hormone should look no further than these and similar peptide treatments. If you are looking for more energy, improved body composition, and general anti-aging effects, a treatment combining these two potent growth hormone secretagogues is an excellent choice.
While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.
- Prakash, A., & Goa, K. L. (1999). Sermorelin: A Review of its Use in the Diagnosis and Treatment of Children with Idiopathic Growth Hormone Deficiency. BioDrugs, 12(2), 139–157.
- Tritos, N & Kokkotou, E. (2006). The Physiology and Potential Clinical Applications of Ghrelin, a Novel Peptide Hormone. Mayo Clin Proc. May 2006;81(5):653-660
- Merriam GR, Hersch EC. Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus? Clin Interv Aging. 2008;3(1):121–9. Retrieved from