Sermorelin is a synthetic growth hormone secretagogue. It is a small peptide made up of 29 amino acids. It stimulates the release of natural growth hormone from your pituitary gland. Many people use sermorelin to counteract the natural decline in growth hormone associated with aging. Growth hormone levels tend to decline by about 15% per decade, starting around age 30.1,2
The pituitary gland secretes human growth hormone and has many effects on the body, many of which are mediated by IGF, including:
Declines in growth hormone are associated with less energy, slower metabolism, reduced muscle mass, increased abdominal fat, trouble sleeping, cognitive changes, and increased recovery time.3
Over 2,000 papers have been published, leading to a consensus that growth hormone replacement can reverse many of the abnormalities associated with age-related growth hormone deficiency.4,5
Research has suggested that growth hormone secretagogues, like sermorelin, appear safe, with very few adverse effects reported.6,7 The most common side effects associated with sermorelin use are:
Rare, more serious side effects can occur. Call your doctor if you experience these side effects.
Sermorelin works best if taken at least two hours after eating and two hours before eating your next meal. This is so the insulin released after eating does not interfere with the release of growth hormone and IGF-1.
Growth hormone rises within about 20 minutes after injecting sermorelin. Growth hormone medicates the release of IGF-1 in the liver. IGF-1 and insulin released after a meal may have competing effects.
To minimize potential side effects from using sermorelin and maximize growth hormone release, stay well-hydrated and avoid consuming high glycemic foods that cause insulin spikes.
According to drugs.com, there should not be an interaction between alcohol use and sermorelin. However, alcohol, like food, affects insulin release. Drinking an alcoholic beverage within two hours of taking sermorelin may make sermorelin less effective.
Side effects from consuming alcohol and taking sermorelin overlap. Using these together may worsen these side effects.
Sermorelin reaches its peak blood level within 5 to 20 minutes after injection. However, it may take several months to notice the benefits. Each person responds to medication differently. Contact your doctor if you do not experience increased muscle strength and decreased fat mass within 3 to 6 months.
The best time to take sermorelin is before going to sleep. This mimics natural growth hormone release.
There is not enough research to answer this question. Studies on potential anti-aging peptides are expected to increase substantially in the next few decades, as there is a trend toward considering aging as a treatable condition and not an inevitable decline in strength and vitality.
Researchers have observed that sermorelin injection increases human growth hormone levels in the bloodstream. Since human growth hormone declines with age, safely increasing them back to levels associated with greater strength and healthier body composition would be an effective anti-aging therapy.
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While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider. You should always consult a practicing professional who can diagnose your specific case. The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice.