Conclusions of Sermorelin Studies

Medically reviewed by Leann Poston, M.D. on 9/11/2020

One of the most-talked-about anti-aging peptides of the modern age is sermorelin.  Anti-aging peptides work in a manner similar to, but distinctly different from, traditional hormone therapies.  Rather than providing artificial hormones to the body, these peptides bind with receptors in your body, to trigger the natural production of your own hormones.  Most often, anti-aging peptides target the pituitary gland, in order to trigger the production of human growth hormone.  As such, these peptides are known as growth hormone-releasing hormones or growth hormone-releasing peptides.  Sermorelin is one of these peptides and has a substantial body of science behind it supporting its function, benefits, and safety.  In this guide, we’ll take a look at some of these Sermorelin studies, and summarize the conclusions and findings.  This will help to demonstrate the foundations on which the use of Sermorelin for anti-aging purposes are based, and further support the claims regarding the benefits that people can realize from a Sermorelin regimen. 

The Basics of Sermorelin

Sermorelin is known as a growth hormone secretagogue – it doesn’t directly mimic human growth hormone action.  Rather, it triggers the pituitary gland to produce human growth hormone.  This is normally the role of growth hormone-releasing hormone, of which sermorelin is an analog.  Human growth hormone plays several important roles in the body – promoting growth in the young and continuing to be critical for a variety of body systems throughout the balance of adult life (Sigalos & Pastuszak, 2017).  Unfortunately, the levels of circulating growth hormone in the body tend to decline by as much as 14% per decade, starting around age 30 (Iranmanesh et al., 1991; Giustina & Veldhuis, 1998).  The result of this decline is seen in many of the typical signs and symptoms of aging – less energy, slower metabolism, higher body fat, trouble sleeping, poor wound healing or injury recovery, a weakened immune system, and more (Garcia et al., 2019). 

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The goal of treatment with sermorelin is to help reverse many of these problems by increasing the level of human growth hormone in the body.  This is done by encouraging the pituitary gland to produce more of the body’s own natural human growth hormone – closer to the levels you had in your body during young adulthood.  This is generally seen as much safer, with far fewer potential side effects than the kind of traditional therapy that uses direct injections of human growth hormone itself. 

Injecting human growth hormone comes with a range of side effects for most people, some of which can be extremely severe, owing in part to the uneven and unnatural spikes of growth hormone this creates in the body (Erotokritou-Mulligan et al., 2011).  Using sermorelin for a more natural production of the body’s own hormones is far safer, with far fewer side effects, though still allows patients to realize the benefits of having increased levels of human growth hormone in the body.  Many Sermorelin studies have borne out these facts, as we’ll look at it more detail in a moment.

Multiple Sermorelin Uses

In addition to anti-aging treatments, there are other uses for sermorelin too – many of which appear in the same sermorelin studies.  The sermorelin studies on safety for the use of the drug in these other contexts are relevant since they help verify the safe dosages and longer-term use of sermorelin in humans, regardless of the purpose.  Some of these common other uses of sermorelin include as a marker or indicator agent for human growth hormone deficiencies, treatment for the same, and an indicator for pituitary function and pituitary disorders.

What the Science Says: Conclusions of Sermorelin Studies

There have been several sermorelin studies to date, of varying scale, length, and purposes.  This is in addition to clinical trials completed prior to the authorization for sermorelin to be available as a drug on the market (in the late 1980s/early 1990s).  Collectively, these sermorelin studies help validate sermorelin’s safety and efficacy in its role of triggering the production of human growth hormone from the pituitary gland.  Below, we’ve summarized some details and findings of some of the major sermorelin studies.

Synthetic Growth Hormone-Releasing Peptides

A 2017 literature review evaluated the efficacy of synthetic growth hormone-releasing peptides, such as sermorelin.  It lays the foundation for further development of drugs and treatments based on the action of growth hormone-releasing peptides.  Importantly, and consistent with most Sermorelin studies, this study establishes that GHRPs like Sermorelin “exhibit a broad safety profile”. 

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Adult-Onset Growth Hormone Insufficiency

In this study from 2006, Walker (2006) looked at the efficacy of growth hormone-releasing peptides, such as sermorelin, for treating adult-onset growth hormone insufficiency.  While more serious than the natural loss of growth hormone that comes with age, the same fundamental principles of why this is problematic, and likewise how sermorelin would be a better choice to treat it, are applicable here.  Direct treatment with human growth hormone has several side effects, cited in the study.  By contrast, sermorelin has fewer side effects and, unlike human growth hormone, is not illegal for treating anti-aging.

Effects on the Immune System

One of the earlier sermorelin studies in the field, this 1997 study looked at sermorelin and its effects on the immune system of aging men and women.  The net result was that the administration of sermorelin, through its growth hormone-releasing mechanism of action, had a significant and “profound immune-enhancing effect and may be of therapeutic benefit in states of compromised immune function (Khorram et al., 1997).”

Sermorelin Reverses Decreased Growth Hormone Levels in Older Men

Perhaps one of the very earliest studies into sermorelin following its clinical approval, this 1992 study validates that sermorelin and other growth hormone-releasing hormones can reverse the natural decline in growth hormone levels found in aging men.  Further, this (along with many sermorelin studies) posited that long-term treatment could improve age-related body changes, effectively offsetting the metabolic and other problems that often develop or exacerbate with increasing age. 

Effects of Single Nightly Injections of Sermorelin in Elderly Men

In accordance with the findings of other sermorelin studies, this 1997 study found that GHRH analogs like sermorelin may help reverse some muscle composition, metabolism, and skeletal-related problems that typically develop with age.  Importantly, as with all of the studies cited, there were no serious adverse effects noticed from super-clinical dosages of the medication, meaning the lower doses used clinically for anti-aging treatment should be even safer than that. 

Where to Buy Sermorelin

The body of evidence is quite clear that sermorelin acts to increase circulating levels of growth hormone in the body, and does so with minimal and minor side effects in the vast majority of patients.  Sermorelin is only available by prescription. At Invigor Medical, we make it easy to consult with health care providers, by providing telemedicine consultations.  If approved for treatment, you can receive your prescription for sermorelin and get it filled through our reputable, US-based online pharmacy, and have it shipped right to your home!  Then, you can start to realize the benefits of a sermorelin anti-aging peptide regimen. 

Frequently Asked Questions

Does sermorelin really work?

The sermorelin studies indicate that there are measurable increases in growth hormone levels after injecting sermorelin, specifically in those who have growth hormone insufficiency, as well as in aging populations with naturally decreased levels of circulating human growth hormone.  As with all medications, however, effects can vary by individual.  For most people who take sermorelin to increase their level of human growth hormone production, noticeable effects on mitigating the side-effects of aging can be realized in as little as 3 to 6 months of regular administration. 

How long does sermorelin take to work?

Sermorelin reaches its peak level in the blood within 5 to 20 minutes after injection.   However, it can take a period of several months to achieve the maximum effect.  For most people, this loading period takes 3 to 6 months of regular daily use of sermorelin. 

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Is sermorelin legal?

As is pointed out in several of the sermorelin studies we’ve cited, sermorelin is entirely legal and has no restrictions on off-label use.  This enables scientists to experiment with dosages and protocols and develop new treatments based on the mechanism of action of sermorelin and similar drugs.  The same cannot be said of actual synthetic human growth hormone, which is far more dangerous, with far more serious side effects, and therefore is much more highly regulated.  However, it should be noted that even growth hormone-releasing peptides like sermorelin may be banned substances for competitive athletics because of the metabolic, muscle, and energy-producing edge that they can provide.  This does not, however, have any effect on their overall legal status for use. 

Concluding Thoughts

Richard Walker, M.D., Ph.D., is considered an expert on sermorelin and growth hormone secretagogues. His research has demonstrated the other than injection site redness and irritation; sermorelin is safe and effective. He recommends exercise to improve the effects of sermorelin on the body. For anti-aging purposes, regular administration of sermorelin can help offset the natural changes that occur with aging, by increasing circulating levels of human growth hormone. 

ALSO READ – 4 Fundamental Reasons to Choose Sermorelin Over HGH for Anti-Aging

DISCLAIMER

While we strive to always provide accurate, current, and safe advice in all of our articles and guides, it’s important to stress that they are no substitute for medical advice from a doctor or healthcare provider.  You should always consult a practicing professional who can diagnose your specific case.  The content we’ve included in this guide is merely meant to be informational and does not constitute medical advice. 

References

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  • Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. Journal of Clinical Endocrinology and Metabolism. 1991;73(5):1081–1088.
  • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocrine Reviews. 1998;19(6):717–797.
  • Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. Is Sermorelin Worth It? Buy Sermorelin Injections Online. 2019 Oct 7. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. https://www.ncbi.nlm.nih.gov/books/NBK279163/
  • Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: a review. Open access journal of sports medicine2, 99–111. https://doi.org/10.2147/OAJSM.S11626
  • Berlanga-Acosta, J., Abreu-Cruz, A., Herrera, D., Mendoza-Marí, Y., Rodríguez-Ulloa, A., García-Ojalvo, A., Falcón-Cama, V., Hernández-Bernal, F., Beichen, Q., & Guillén-Nieto, G. (2017). Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects. Clinical Medicine Insights. Cardiology11, 1179546817694558. https://doi.org/10.1177/1179546817694558
  • Walker R. F. (2006). Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clinical interventions in aging1(4), 307–308. https://doi.org/10.2147/ciia.2006.1.4.307
  • Khorram O, Yeung M, Vu L, Yen SS. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997;82(11):3590-3596. doi:10.1210/jcem.82.11.4363
  • Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab. 1992;75(2):530-535. doi:10.1210/jcem.75.2.1379256
  • Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997;46(1):89-96. doi:10.1016/s0026-0495(97)90174-8